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ORPHA:622099

Superior mesenteric artery syndrome

low confidenceDisorder

Also known as: SMAS · Wilkie syndrome

Publications

2,174

Trials

4

Interventional, condition-specific

Researchers

1,039

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (3)

superior mesenteric artery syndrome · superior mesenteric artery syndromic disease · syndromic disease of superior mesenteric artery

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    2,174 matched papers (1,119 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    4 matched on ClinicalTrials.gov (1 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

2,174

2,174 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

2,174 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

1,119 in the last 10 years · low confidence

Phrase hits: 2,174 · MeSH hits: 69

Open Europe PMC search

Who's working on it?

1,039

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Liu Y4 papers · 2026

    Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.

    Papers in Europe PMC
  2. 02
    Wang X4 papers · 2026

    Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao University Qingdao, Shandong, China.

    Papers in Europe PMC
  3. 03
    Yang H3 papers · 2026

    Doctor of Medicine, Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.

    Papers in Europe PMC
  4. 04
    Acharya A2 papers · 2026

    Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.

    Papers in Europe PMC
  5. 05
    Alami B2 papers · 2026

    Department of Adult Radiology, CHU Hassan II Fez, Sidi Mohammed Ben Abdellah University, Fez, Morocco.

    Papers in Europe PMC
  6. 06
    Boubbou M2 papers · 2026

    Department of Mother and Child Radiology, CHU Hassan II Fez, Sidi Mohammed Ben Abdellah University, Fez, Morocco.

    Papers in Europe PMC
  7. 07
    Chaouche I2 papers · 2026

    Department of Adult Radiology, CHU Hassan II Fez, Sidi Mohammed Ben Abdellah University, Fez, Morocco.

    Papers in Europe PMC
  8. 08
    El Bouardi N2 papers · 2026

    Department of Adult Radiology, CHU Hassan II Fez, Sidi Mohammed Ben Abdellah University, Fez, Morocco.

    Papers in Europe PMC
  9. 09
    Fujiwara T2 papers · 2026

    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama, Okayama ,

    Papers in Europe PMC
  10. 10
    Gharti SB2 papers · 2024

    Universal College of Medical Sciences and Teaching Hospital, Bhairahawa, Nepal.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

4

interventional trials for this specific condition

4 interventional trials matched this specific condition name; 1 currently recruiting in our sample.

Data as of 27 July 2026

4 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 86.7th percentile).

low confidence · 86.7th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

4 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Superior mesenteric artery syndrome" OR "Wilkie syndrome" OR "superior mesenteric artery syndromic disease" OR "syndromic disease of superior mesenteric artery" OR "syndromic disease of the superior mesenteric artery"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Superior Mesenteric Artery Syndrome

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Superior mesenteric artery syndrome" OR "Wilkie syndrome" OR "superior mesenteric artery syndromic disease" OR "syndromic disease of superior mesenteric artery" OR "syndromic disease of the superior mesenteric artery"

Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 4 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: SMAS

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (2174) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T19:10:33.091Z