ORPHA:618891
Chronic neurovisceral acid sphingomyelinase deficiency
Also known as: Chronic neurovisceral ASMD · NPD-A/B · Niemann-Pick disease type A/B
Publications
322
80.7th percentile
Trials
0
Interventional, condition-specific
Researchers
1,354
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
A rare acid sphingomyelinase deficiency characterized by mild to massive , hypersplenism leading to thrombocytopenia, interstitial lung disease, dyslipidemia and central nervous system manifestations (including , and ). Some affected individuals may present with coarse facial features.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0850058
- UMLS:C5539139
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
322 matched papers (229 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
322
322 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
322 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
229 in the last 10 years · high confidence · 80.7th percentile (publications denominator)
Phrase hits: 322 · MeSH hits: 0
Who's working on it?
1,354
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Giugliani R12 papers · 2026
Postgraduate Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Papers in Europe PMC - 02Lidove O8 papers · 2026
Internal Medicine Department, Reference Center for Lysosomal Diseases, Groupe Hospitalier Diaconesses-Croix Saint Simon, AIMS, SysMedLab, Referral Center for Lysosomal Diseases, Filière G2M, Paris, 75020, France.
Papers in Europe PMC - 03Jones SA7 papers · 2025
St Mary's Hospital, Manchester University Foundation Trust, University of Manchester, Manchester, UK.
Papers in Europe PMC - 04Mengel E7 papers · 2026
University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Papers in Europe PMC - 05Wasserstein MP7 papers · 2026
Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
Papers in Europe PMC - 06Fiori L5 papers · 2026
Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy.
Papers in Europe PMC - 07Han L5 papers · 2023
Department of Pediatric Endocrinology and Genetic Metabolism, Shanghai Institute for Pediatric Research & Center for Clinical Innovation and Research, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Papers in Europe PMC - 08Montanari C5 papers · 2026
Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy.
Papers in Europe PMC - 09Schuchman EH5 papers · 2024
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Papers in Europe PMC - 10Sheth J5 papers · 2026
FRIGE’s Institute of Human Genetics, FRIGE House, Ahmedabad-380015, Gujarat, India
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Chronic neurovisceral acid sphingomyelinase deficiency" OR "Chronic neurovisceral ASMD" OR "NPD-A/B" OR "Niemann-Pick disease type A/B"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Chronic neurovisceral acid sphingomyelinase deficiency" OR "Chronic neurovisceral ASMD" OR "NPD-A/B" OR "Niemann-Pick disease type A/B"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T19:07:10.871Z