ORPHA:617301
Selective intrauterine growth restriction
Also known as: Selective fetal growth restriction · sFGR · sIUGR
Publications
797
91.8th percentile
Trials
0
Interventional, condition-specific
Researchers
922
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
A rare disorder related to monochorionic twin pregnancy characterized by unequal placental sharing leading to growth restriction in one twin according to the following criteria: estimated fetal weight (EFW) of one twin below the 3rd percentile as a solitary parameter, or fulfilment of at least two out of four contributory parameters (EFW of one twin below the 10th percentile, abdominal circumference of one twin below the 10th percentile, EFW discordance of ≥ 25%, umbilical artery pulsatility index of the smaller twin above the 95th percentile). Early severe forms are associated with a significant risk of intrauterine demise or neurological adverse outcome for both twins.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0850015
- UMLS:C5681824
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
797 matched papers (672 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
797
797 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
797 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
672 in the last 10 years · medium confidence · 91.8th percentile (publications denominator)
Phrase hits: 797 · MeSH hits: 0
Who's working on it?
922
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Wang X18 papers · 2026
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, P.R. China.
Papers in Europe PMC - 02Wei Y16 papers · 2026
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Papers in Europe PMC - 03Zhao Y15 papers · 2026
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, P.R. China.
Papers in Europe PMC - 04Wang Y14 papers · 2026
The First Clinical Medical College,, Southern Medical University, Guangzhou, China.
Papers in Europe PMC - 05Yang J13 papers · 2026
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Papers in Europe PMC - 06Li L12 papers · 2026
Department of Obstetrics and Gynecology, Fetal Medicine Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Papers in Europe PMC - 07Khalil A11 papers · 2026
Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.
Papers in Europe PMC - 08Yuan P10 papers · 2026
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, P.R. China.
Papers in Europe PMC - 09Zhang Y10 papers · 2026
Zhuhai Center for Maternal and Child Care, Ningxi Road, Zhuhai, Guangdong, 519000, China.
Papers in Europe PMC - 10Hu Y9 papers · 2026
, Yongfeng Avenue, Anshun, Guizhou, 561000, China. huye57@hotmail.com.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name. 1 observational study did — shown below because natural-history and cohort work can be an important step toward a trial.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
medium confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Observational and natural-history studies
1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT05952583·RECRUITING·Selective Fetal Growth Restriction in Monochorionic Twins - an International Investigation
Conditions: Twin; Pregnancy, Affecting Fetus or Newborn · Fetal Growth Retardation · Twin Monochorionic Diamniotic Placenta · Twin Diseases·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Selective intrauterine growth restriction" OR "Selective fetal growth restriction" OR "sIUGR"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Selective intrauterine growth restriction" OR "Selective fetal growth restriction" OR "sIUGR"
Study-type breakdown: 0 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: sFGR
Confidence reasoning
- Preferred label is multi-word and distinctive
- 1 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T19:05:35.435Z