ORPHA:615970
Chronic intervillositis of unknown etiology
Also known as: CIUE
Clinical definition (Orphanet)
A rare disorder related to pregnancy characterized by a placental inflammatory process with clusters of histiocytes and associated fibrin in intervillous spaces, resulting in adverse pregnancy outcomes including intrauterine growth restriction, preterm birth, and pregnancy loss. Higher grading according to the proportion of involved intervillous space has been associated with poorer outcomes. There is a significant risk of recurrence in subsequent pregnancies.
How rare: How common this is has not been clearly measured.
Is anyone studying this?
43
43 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=183) is 38.
43 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 38 (publications denominator n=183).
38 in the last 10 years · medium confidence · 50.3th percentile (publications denominator)
Is a treatment being tested?
0
trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 26 July 2026
No matched interventional trials. This is true for 59.2% of diseases in the trials denominator (151 of 255). Here are the researchers publishing on it.
medium confidence · 29.6th percentile (trials denominator)
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Who's working on it?
192
Distinct author names in 43 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Terry J9 papers · 2026
Department of Pathology and Laboratory Medicine, BC Children's Hospital, Vancouver, British Columbia, Canada.
Papers in Europe PMC - 02Bedaiwy MA5 papers · 2026
University of British Columbia, Department of Obstetrics and Gynaecology, Vancouver, BC, V6Z 2K8, Canada. Electronic address: mohamed.bedaiwy@cw.bc.ca.
Papers in Europe PMC - 03Blanco P4 papers · 2024
Laboratoire d'immunologie, hôpital Pellegrin, CHU de Bordeaux, 33000 Bordeaux, France; Centre de référence des maladies auto-immunes systémiques rares de l'Est et du Sud-Ouest, CHU de Bordeaux, 33000 Bordeaux, France; Centre de compétence des microangiopathies thrombotiques, CHU de Bordeaux, 33000 Bordeaux, France.
Papers in Europe PMC - 04Bloemenkamp KWM4 papers · 2023
Department of Obstetrics, University Medical Center Utrecht, Wilhelmina Children's Hospital, Birth Centre, Lundlaan 6, 3584 EA Utrecht, The Netherlands.
Papers in Europe PMC - 05Bos M4 papers · 2023
Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. Electronic address: m.bos@lumc.nl.
Papers in Europe PMC - 06Lazaro E4 papers · 2024
Service de médecine interne, hôpital du Haut-Lévêque, CHU de Bordeaux, 33000 Bordeaux, France; Centre de référence des maladies auto-immunes systémiques rares de l'Est et du Sud-Ouest, CHU de Bordeaux, 33000 Bordeaux, France; Centre de compétence des microangiopathies thrombotiques, CHU de Bordeaux, 33000 Bordeaux, France. Electronic address: estibaliz.lazaro@chu-bordeaux.fr.
Papers in Europe PMC - 07Mattuizzi A4 papers · 2024
Service de gynécologie-obstétrique, hôpital Pellegrin, CHU de Bordeaux, 33000 Bordeaux, France; Centre de référence des maladies auto-immunes systémiques rares de l'Est et du Sud-Ouest, CHU de Bordeaux, 33000 Bordeaux, France.
Papers in Europe PMC - 08Nikkels PGJ4 papers · 2023
Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Papers in Europe PMC - 09Sentilhes L4 papers · 2024
Service de gynécologie-obstétrique, hôpital Pellegrin, CHU de Bordeaux, 33000 Bordeaux, France; Centre de référence des maladies auto-immunes systémiques rares de l'Est et du Sud-Ouest, CHU de Bordeaux, 33000 Bordeaux, France; Centre de compétence des microangiopathies thrombotiques, CHU de Bordeaux, 33000 Bordeaux, France.
Papers in Europe PMC - 10Fayek B3 papers · 2026
Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada; Division of Reproductive Endocrinology & Infertility, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada; Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Papers in Europe PMC
Recruiting interventional trials
Trials testing a treatment from the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it above — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored below but are not added to the query string.
"Chronic intervillositis of unknown etiology"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Chronic intervillositis of unknown etiology" OR "Chronic intervillositis of the unknown etiology"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Cross-references (from Mondo): UMLS:C5680386
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: CIUE
Confidence reasoning
- Preferred label is multi-word and distinctive
- 1 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus