ORPHA:60039
Pudendal nerve entrapment syndrome
Also known as: Alcock syndrome · Pudendal algia · Pudendal neuralgia · Pudendal neuralgia by pudendal nerve entrapment · Pudendal neuropathic pain syndrome · Pudendal neuropathy · Pudendalgia
Publications
989
84.3th percentile
Trials
14
Interventional, condition-specific
Researchers
971
Distinct authors in sample
Gene link
—
Readiness
3/6
Stages with a signal
Clinical definition (Orphanet)
A rare, acquired peripheral characterized by chronic neuropathic pain involving the sensory territory of the pudendal nerve (from clitoris to anus or from penis to anus) aggravated by sitting. It is often associated with pelvic dysfunction.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0018957
- MeSH:D060545
- UMLS:C1997249
Additional Mondo synonyms (5)
neuralgia of pudendal nerve · pudendal algia · pudendal nerve entrapment syndrome · pudendal nerve neuralgia · pudendal neuralgia by pudendal nerve entrapment
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
3/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
989 matched papers (566 in last 10 years) Source
- Phenotype characterisedPresent
19 HPO annotations (e.g. Neuralgia; Pruritus; Somatic sensory dysfunction) Source
- Animal modelNot found
No Alliance genotype “model of” associations via Monarch for these Mondo IDs
- Orphan designationNot found
No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source
- Interventional trialPresent
14 matched on ClinicalTrials.gov (4 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
19
Associated phenotypes · MONDO:0018957
- Neuralgia
- Pruritus
- Somatic sensory dysfunction
- Neoplasm of the genitourinary tract
- Allodynia
Showing 5 of 19 — open Monarch for the full list.
Animal models (Monarch / Alliance)
None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.
Monarch fetch 2026-07-29
Therapies
Designations, candidates, and chemicals
FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.
Orphan designation (FDA · EMA)
No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.
Open Targets candidates
No drugs or clinical candidates returned for this Mondo ID on Open Targets.
CTD chemicals (MyDisease.info)
No CTD chemical associations returned for this Mondo ID.
Literature
Is anyone studying this?
989
989 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.
989 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).
566 in the last 10 years · high confidence · 84.3th percentile (publications denominator)
Phrase hits: 989 · MeSH hits: 49
Who's working on it?
971
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Bollens R4 papers · 2025
Department of Urology, Université Nord de France, St Phillibert Hospital, GHICL, Lille, France.
Papers in Europe PMC - 02Chhabra A4 papers · 2025
University of Texas Southwestern, Department of Radiology, Dallas, TX.
Papers in Europe PMC - 03Kale A4 papers · 2026
Department of Obstetrics and Gynecology, University of Health Science Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkey.
Papers in Europe PMC - 04Labat JJ4 papers · 2022
Federative Pelvic Pain Center, Nantes, France; Maurice Bensignor Multidisciplinary Pain Center, Centre Catherine de Sienne, Nantes, France.
Papers in Europe PMC - 05
- 06Ploteau S4 papers · 2022
Department of Gynecology and Obstetrics, Center Hospitalier Universitaire, Nantes, France.
Papers in Europe PMC - 07Riant T4 papers · 2022
Federative Pelvic Pain Center, Nantes, France; Maurice Bensignor Multidisciplinary Pain Center, Centre Catherine de Sienne, Nantes, France.
Papers in Europe PMC - 08Robert R4 papers · 2024
Federative Pelvic Pain Center, Nantes, France; Maurice Bensignor Multidisciplinary Pain Center, Centre Catherine de Sienne, Nantes, France.
Papers in Europe PMC - 09Usta T4 papers · 2026
Department of Obstetrics and Gynecology, Acibadem University, Altunizade Hospital, Istanbul, Turkey.
Papers in Europe PMC - 10
Clinical research
Is a treatment being tested?
14
interventional trials for this specific condition
14 interventional trials matched this specific condition name; 4 currently recruiting in our sample.
Data as of 11 September 2026
14 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 93.7th percentile).
high confidence · 93.7th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
14 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT07356102·RECRUITING·Conventional Versus High-Voltage Long-Duration Pulsed Radiofrequency of the Pudendal Nerve
Not reviewed·Conditions: Pudendal Neuralgia·Matched via name + MeSH
- NCT06644261·RECRUITING·Transvaginal Versus Fluoroscopy-guided Trans Gluteal Pudendal Nerve Block for Pudendal Neuralgia
Not reviewed·Conditions: Pudendal Neuralgia · Chronic Pelvic Pain Syndrome·Matched via name + MeSH
- NCT07446556·ENROLLING BY INVITATION·Exercise Program in Women With Pudendal Neuralgia
Not reviewed·Conditions: Pudendal Neuralgia- Physiotherapy·Matched via name + MeSH
- NCT06872437·RECRUITING·Evaluation of the Efficacy of Therapeutic Infiltrations of the Pudendal Nerve, Performed Under Neurostimulation on Pain, 1 Month After an Infiltration of Local Anaesthetic, in the Treatment of Pudendal Neuralgia.
Not reviewed·Conditions: Pudendal Neuralgia·Matched via name + MeSH
Observational and natural-history studies
7 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT06413277·RECRUITING·Targeting the Conus Medullaris With ECAP-Controlled Closed-Loop SCS for Treatment of Chronic Pelvic Pain: HOPE Trial
Not reviewed·Conditions: Chronic Pelvic Pain · Pudendal Neuralgia·Matched via name + MeSH
- NCT06578767·RECRUITING·Decompression of Pudendal and Inferior Cluneal Nerves Using Robot-assisted Laparoscopy for Entrapment Neuralgias : the X-DECO Study
Not reviewed·Conditions: Pudendal Neuralgia·Matched via name + MeSH
- NCT06796595·RECRUITING·Perioperative Medical Program to Optimize Nerve Regeneration After Robot-assisted Laparoscopic Neurolyses of Pudendal and/or Inferior Cluneal Nerves for Chronic Neuralgias: Results After 1-year Follow-up
Not reviewed·Conditions: Pudendal Neuralgia · Neuralgia·Matched via name + MeSH
Other registries (secondary)
Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.
raw 3 · after dedupe 3 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 3 · dropped 0 · fetched 2026-07-30
Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri
No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).
Uncertain / not reviewed (3)
- isrctn·ISRCTN33909010·No longer recruiting·A phase 3 randomised placebo- and active comparator-controlled, clinical trial to study the safety and efficacy of two doses of lurasidone HCL in acutely psychotic patients with schizophrenia
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN16838597·No longer recruiting·A phase three randomised, placebo-controlled, clinical trial to study the safety and efficacy of three doses of lurasidone hydrochloride (HCl) in acutely psychotic patients with schizophrenia
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN97049967·No longer recruiting·Phase 3 long-term safety, tolerability and effectiveness of lurasidone in subjects with schizophrenia or schizoaffective disorder
skipped — LLM skipped (--skip-llm)
Where to find support
Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.
Orphanet entry for Pudendal nerve entrapment syndrome — check Associations / patient organisations on that page.
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Pudendal nerve entrapment syndrome" OR "Alcock syndrome" OR "Pudendal algia" OR "Pudendal neuralgia" OR "Pudendal neuralgia by pudendal nerve entrapment" OR "Pudendal neuropathic pain syndrome" OR "Pudendal neuropathy" OR "Pudendalgia" OR "neuralgia of pudendal nerve" OR "neuralgia of the pudendal nerve" OR "pudendal nerve neuralgia"
MeSH descriptor terms unioned into the query: Pudendal Neuralgia
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Pudendal nerve entrapment syndrome" OR "Alcock syndrome" OR "Pudendal algia" OR "Pudendal neuralgia" OR "Pudendal neuralgia by pudendal nerve entrapment" OR "Pudendal neuropathic pain syndrome" OR "Pudendal neuropathy" OR "Pudendalgia" OR "neuralgia of pudendal nerve" OR "neuralgia of the pudendal nerve" OR "pudendal nerve neuralgia"
Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 14 interventional · 7 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T01:05:51.589Z