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ORPHA:599480

Acquired hemophilia A

medium confidenceDisorder

Also known as: AHA · Acquired F8 deficiency · Acquired factor VIII deficiency

Query health: suspect — Only one of 2 strategies returned hits (phrase).

Publications

1,887

93.6th percentile

Trials

8

Interventional, condition-specific

Researchers

1,065

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    1,887 matched papers (1,178 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    8 matched on ClinicalTrials.gov (1 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

1,887

1,887 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

1,887 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

1,178 in the last 10 years · medium confidence · 93.6th percentile (publications denominator)

Phrase hits: 1,887 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,065

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Tiede A6 papers · 2026

    Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany. Electronic address: tiede.andreas@mh-hannover.de.

    Papers in Europe PMC
  2. 02
    Ieko M4 papers · 2026

    Department of Nursing, Faculty of Health and Medical Sciences, Sapporo University of Health Sciences, Sapporo, Japan.

    Papers in Europe PMC
  3. 03
    Miesbach W4 papers · 2026

    Medical Clinic II, Institute of Transfusion Medicine, Goethe University, Frankfurt, Germany.

    Papers in Europe PMC
  4. 04
    Oldenburg J4 papers · 2026

    Institute of Experimental Hematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany.

    Papers in Europe PMC
  5. 05
    Pfrepper C4 papers · 2026

    Division of Hemostaseology, Medical Department I, University Hospital Leipzig, Leipzig, Germany.

    Papers in Europe PMC
  6. 06
    Wang Y4 papers · 2026

    Department of Clinical Laboratory of Guangxi Medical University Cancer Hospital, Nanning, China.

    Papers in Europe PMC
  7. 07
    Werwitzke S4 papers · 2026

    Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

    Papers in Europe PMC
  8. 08
    Dobbelstein C3 papers · 2026

    Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

    Papers in Europe PMC
  9. 09
    Eichler H3 papers · 2026

    Institute for Clinical Hemostaseology and Transfusion Medicine, Saarland University and University Hospital, Homburg/Saar, Germany.

    Papers in Europe PMC
  10. 10
    Greil R3 papers · 2026

    Medical Department III, Paracelsus Medical University Salzburg, Salzburg Cancer Research Institute-Center for Clinical Cancer and Immunology Trials, Cancer Cluster Salzburg, Salzburg, Austria.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

8

interventional trials for this specific condition

8 interventional trials matched this specific condition name; 1 currently recruiting in our sample.

Data as of 27 July 2026

8 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 90.6th percentile).

medium confidence · 90.6th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

8 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: acquired hemophilia

0

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Parent-category matching found a broader label but no interventional trials under it. How we count trials.

Observational and natural-history studies

5 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Acquired hemophilia A" OR "Acquired F8 deficiency" OR "Acquired factor VIII deficiency"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Factor 8 deficiency, acquired

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Acquired hemophilia A" OR "Acquired F8 deficiency" OR "Acquired factor VIII deficiency" OR "Factor 8 deficiency, acquired"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 8 interventional · 5 observational · 1 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"acquired hemophilia"

Query health: suspect — strategies attempted: phrase, mesh; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: AHA

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T18:57:25.160Z