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ORPHA:585956

B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)

high confidenceSubtype of disorder

Also known as: B lymphoblastic leukemia lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1

Query health: suspect — Source fetch failed for trials.

Publications

11

21.7th percentile

Trials

—

Interventional, condition-specific

Researchers

48

Distinct authors in sample

Gene link

—

Readiness

1/6

Stages with a signal

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (6)

B acute lymphoblastic leukaemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) · B acute lymphoblastic leukemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) · B lymphoblastic leukaemia lymphoma with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) (morphologic abnormality) · B lymphoblastic leukemia lymphoma with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) (morphologic abnormality) · B-acute lymphoblastic leukaemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) · B-acute lymphoblastic leukemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1)

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

1/6 stages with a signal

Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    11 matched papers (6 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialNot checked

    Trial fetch failed or incomplete

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

11

11 papers have ever been indexed under this name. For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

11 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

6 in the last 10 years · high confidence · 21.7th percentile (publications denominator)

Phrase hits: 11 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

48

Distinct author names in 11 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Adzersen KH1 paper · 2016

    Federal State Cancer Registry of Baden-Württemberg, Epidemiological Cancer Registry, German Cancer Research Center, Heidelberg, Germany.

    Papers in Europe PMC
  2. 02
    Aplan PD1 paper · 2009
    Papers in Europe PMC
  3. 03
    Aureli A1 paper · 2023

    CNR Institute of Translational Pharmacology, Via Carducci 32, 67100 L'Aquila, Italy.

    Papers in Europe PMC
  4. 04
    Bataller A1 paper · 2021

    Josep Carreras Leukemia Research Institute, Campus Clinic, School of Medicine, University of Barcelona, 08036 Barcelona, Spain.

    Papers in Europe PMC
  5. 05
    Becker N1 paper · 2016

    Federal State Cancer Registry of Baden-Württemberg, Epidemiological Cancer Registry, German Cancer Research Center, Heidelberg, Germany. n.becker@dkfz.de.

    Papers in Europe PMC
  6. 06
    Brunner AM1 paper · 2020

    Massachusetts General Hospital, Zero Emerson Place Suite 118, Boston, MA, 02114, USA. abrunner@mgh.harvard.edu.

    Papers in Europe PMC
  7. 07
    Cho YU1 paper · 2025

    Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.

    Papers in Europe PMC
  8. 08
    Chu D1 paper · 2025

    Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.

    Papers in Europe PMC
  9. 09
    Dorantes-Acosta E1 paper · 2012

    Leukemia Clinic, Mexican Children's Hospital Federico Gómez, 06720 Mexico City, DF, Mexico.

    Papers in Europe PMC
  10. 10
    Farzaneh MR1 paper · 2013
    Papers in Europe PMC

Clinical research

Is a treatment being tested?

—

interventional trials for this specific condition

We could not load trial data for this condition right now.

Data as of 27 July 2026

high confidence

Recruiting interventional trials

From the matched ClinicalTrials.gov set

Trial data could not be loaded for this build. This is not the same as finding zero interventional trials.

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)" OR "B lymphoblastic leukemia lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1" OR "B acute lymphoblastic leukaemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1)" OR "B acute lymphoblastic leukemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1)" OR "B lymphoblastic leukaemia lymphoma with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) (morphologic abnormality)" OR "B lymphoblastic leukemia lymphoma with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) (morphologic abnormality)" OR "B-acute lymphoblastic leukaemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1)" OR "B-acute lymphoblastic leukemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1)"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

(empty)

Query health: suspect — strategies attempted: phrase; with hits: phrase

Source errors: trials: Error: HTTP 400 for https://clinicaltrials.gov/api/v2/studies?query.cond=%22B-lymphoblastic%20leukemia%2Flymphoma%20with%20t(1%3B19)(q23%3Bp13.3)%22%20OR%20%22B%20lymphoblastic%20leukemia%20lymphoma%20with%20t(1%3B19)(q23%3Bp13.3)%3B%20TCF3-PBX1%22%20OR%20%22B%20acute%20lymphoblastic%20leukaemia%20with%20t(1%3B19)(q23%3Bp13.3)%3B%20E2A-PBX1%20(TCF3-PBX1)%22%20OR%20%22B%20acute%20lymphoblastic%20leukemia%20with%20t(1%3B19)(q23%3Bp13.3)%3B%20E2A-PBX1%20(TCF3-PBX1)%22%20OR%20%22B%20lymphoblastic%20leukaemia%20lymphoma%20with%20t(1%3B19)(q23%3Bp13.3)%3B%20E2A-PBX1%20(TCF3-PBX1)%20(morphologic%20abnormality)%22%20OR%20%22B%20lymphoblastic%20leukemia%20lymphoma%20with%20t(1%3B19)(q23%3Bp13.3)%3B%20E2A-PBX1%20(TCF3-PBX1)%20(morphologic%20abnormality)%22%20OR%20%22B-acute%20lymphoblastic%20leukaemia%20with%20t(1%3B19)(q23%3Bp13.3)%3B%20E2A-PBX1%20(TCF3-PBX1)%22%20OR%20%22B-acute%20lymphoblastic%20leukemia%20with%20t(1%3B19)(q23%3Bp13.3)%3B%20E2A-PBX1%20(TCF3-PBX1)%22&format=json&pageSize=100&countTotal=true

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T18:44:44.593Z