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ORPHA:570762

Infective endocarditis

low confidenceDisorder

Also known as: Infectious endocarditis

Publications

42,170

Trials

63

Interventional, condition-specific

Researchers

1,184

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare infectious disease characterized by inflammation of the endocardium (including native or prosthetic heart valves and indwelling cardiac devices) mainly caused by bacterial (predominantly Staphylococcus and Streptococcus species) or rarely fungal (predominantly Candida and Aspergillus species) infections that the latter are reported to be associated with high morbidity and mortality. Major clinical features include high fever or prolonged subfebrile state, chills, diaphoresis, malaise, asthenia, arthralgia, myalgia, weight loss, headache, nausea, dyspnea, cough, heart murmurs, and petechiae of the skin. The most common complications are embolism in different organs and ischemic stroke, sepsis, heart failure, and renal failure.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (1)

endocarditis infective

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    42,170 matched papers (25,058 in last 10 years) Source

  3. Phenotype characterisedNot found

    No HPO disease–phenotype associations via Monarch for these Mondo IDs

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    63 matched on ClinicalTrials.gov (21 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

None returned for this Mondo ID. That often means “not linked under this ID,” not “no clinical features.”

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

19

Drugs / clinical candidates · MONDO_0000565

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

42,170

42,170 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

42,170 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

25,058 in the last 10 years · low confidence

Phrase hits: 42,170 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,184

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Li Q3 papers · 2026

    Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

    Papers in Europe PMC
  2. 02
    Abd Rani NH2 papers · 2026

    Non-Invasive Cardiovascular Laboratory, National Heart Institute, Kuala Lumpur, Malaysia.

    Papers in Europe PMC
  3. 03
    Alsoufi B2 papers · 2026

    Division of Pediatric Cardiac Surgery, Department of Cardiovascular and Thoracic Surgery, Norton Children's Hospital, University of Louisville, Louisville, USA.

    Papers in Europe PMC
  4. 04
    Arora D2 papers · 2026

    Anaesthesia, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

    Papers in Europe PMC
  5. 05
    Baddour LM2 papers · 2026

    Division of Public Health, Infectious Diseases and Occupational Health, Departments of Medicine and Cardiovascular Medicine, Mayo Clinic, Minnesota, USA.

    Papers in Europe PMC
  6. 06
    Bertolino L2 papers · 2026

    Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.

    Papers in Europe PMC
  7. 07
    Blot M2 papers · 2025

    Department of Infectious Diseases, Université Bourgogne Europe, CHU Dijon Bourgogne, 14 rue Paul Gaffarel, Dijon Cedex, 21000, France.

    Papers in Europe PMC
  8. 08
    Boukobza M2 papers · 2026

    Department of Radiology, Bichat Hospital, Assistance Publique-Hôpitaux de Paris, 46 rue Henri Huchard, 75018 Paris, France. Electronic address: m.boukobza@orange.fr.

    Papers in Europe PMC
  9. 09
    Chen Y2 papers · 2026

    From the Department of Critical Care Medicine, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.

    Papers in Europe PMC
  10. 10
    Dasgupta S2 papers · 2026

    Division of Pediatric Cardiology, Department of Pediatrics, Norton Children's Hospital, University of Louisville, 231 E. Chestnut St., Louisville, LY, 40202, USA.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

63

interventional trials for this specific condition

63 interventional trials matched this specific condition name; 21 currently recruiting in our sample. 31 trials are registered for endocarditis, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 11 September 2026

63 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 97.7th percentile).

low confidence · 97.7th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

63 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: endocarditis

31

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

66 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 40 · after dedupe 40 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 40 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (40)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Infective endocarditis — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Infective endocarditis" OR "Infectious endocarditis" OR "endocarditis infective"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Infective endocarditis" OR "Infectious endocarditis" OR "endocarditis infective"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 63 interventional · 66 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"endocarditis"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (42170) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T18:32:15.870Z