RARE DISEASERESEARCH ATLAS
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ORPHA:570470

Ricin poisoning

high confidenceDisorder

Publications

175

61.7th percentile

Trials

3

Interventional, condition-specific

Researchers

695

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare disorder due to poisoning characterized by acute onset of potentially life-threatening illness following ingestion, inhalation, or injection of ricin, a lectin present in the seeds of Ricinus communis, the castor oil plant. Clinical presentation depends on the route of administration, inhalation being the most toxic route, followed by oral ingestion. Presenting signs and symptoms include nausea, vomiting, diarrhea, hematemesis, and melena (upon ingestion), cough, wheezing, dyspnea, sore throat, and congestion (upon inhalation), and erythema, induration, blisters, capillary leak syndrome, and localized necrosis (upon injection). The condition can progress to , shock, organ failure, pulmonary edema, and respiratory failure.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    175 matched papers (76 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    3 matched on ClinicalTrials.gov

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

175

175 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

175 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

76 in the last 10 years · high confidence · 61.7th percentile (publications denominator)

Phrase hits: 175 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

695

Distinct author names in 175 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Falach R8 papers · 2025

    Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, 19 Reuven Lerer St., Ness-Ziona, 76100, Israel. reutf@iibr.gov.il.

    Papers in Europe PMC
  2. 02
    Kronman C7 papers · 2022

    Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100, Israel. chanochk@iibr.gov.il.

    Papers in Europe PMC
  3. 03
    Sapoznikov A7 papers · 2025

    Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, 19 Reuven Lerer St., Ness-Ziona, 76100, Israel.

    Papers in Europe PMC
  4. 04
    Evgy Y6 papers · 2025

    Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, 19 Reuven Lerer St., Ness-Ziona, 76100, Israel.

    Papers in Europe PMC
  5. 05
    Gal Y6 papers · 2022

    Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, 19 Reuven Lerer St., Ness-Ziona, 76100, Israel.

    Papers in Europe PMC
  6. 06
    Sabo T6 papers · 2022

    Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, 19 Reuven Lerer St., Ness-Ziona, 76100, Israel.

    Papers in Europe PMC
  7. 07
    Aftalion M5 papers · 2025

    Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, 19 Reuven Lerer St., Ness-Ziona, 76100, Israel.

    Papers in Europe PMC
  8. 08
    Avril A5 papers · 2026

    Microbiology and Infectious Diseases Department, Anti-Infectious Biotherapies and Immunity Unit, Army Biomedical Research Institute, 91220 Brétigny-sur-Orge, France.

    Papers in Europe PMC
  9. 09
    Dorner BG5 papers · 2025

    Biological Toxins, Centre for Biological Threats and Special Pathogens, Robert Koch Institute, 13353 Berlin, Germany. dornerb@rki.de.

    Papers in Europe PMC
  10. 10
    Griffiths GD5 papers · 2011

    Biology Department, Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 0JQ, UK. gdgriffiths@dstl.gov.uk

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

3

interventional trials for this specific condition

3 interventional trials matched this specific condition name; none in our sample are currently recruiting. 119 trials are registered for poisoning, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

3 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 85.1th percentile).

high confidence · 85.1th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

3 interventional trials matched after quoted-phrase search and title/condition post-filter.

No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.

Broader category: poisoning

119

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Ricin poisoning"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Ricin poisoning"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 3 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"poisoning"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T18:31:52.752Z