ORPHA:570470
Ricin poisoning
Publications
175
53.6th percentile
Trials
3
Interventional, condition-specific
Researchers
695
Distinct authors in sample
Gene link
—
Readiness
3/6
Stages with a signal
Clinical definition (Orphanet)
A rare disorder due to poisoning characterized by acute onset of potentially life-threatening illness following ingestion, inhalation, or injection of ricin, a lectin present in the seeds of Ricinus communis, the castor oil plant. Clinical presentation depends on the route of administration, inhalation being the most toxic route, followed by oral ingestion. Presenting signs and symptoms include nausea, vomiting, diarrhea, hematemesis, and melena (upon ingestion), cough, wheezing, dyspnea, sore throat, and congestion (upon inhalation), and erythema, induration, blisters, capillary leak syndrome, and localized necrosis (upon injection). The condition can progress to , shock, organ failure, pulmonary edema, and respiratory failure.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
3/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
175 matched papers (76 in last 10 years) Source
- Phenotype characterisedNot found
No HPO disease–phenotype associations via Monarch for these Mondo IDs
- Animal modelNot found
No Alliance genotype “model of” associations via Monarch for these Mondo IDs
- Orphan designationPartial
3 EMA designations (none yet with FDA orphan-indication approval) — e.g. recombinant modified ricin toxin A-chain subunit Source
- Interventional trialPresent
3 matched on ClinicalTrials.gov
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
None returned for this Mondo ID. That often means “not linked under this ID,” not “no clinical features.”
Animal models (Monarch / Alliance)
None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.
Monarch fetch 2026-07-29
Therapies
Designations, candidates, and chemicals
FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.
Orphan designation (FDA · EMA)
3
Designations · no FDA orphan-indication approval yet
- EMA recombinant modified ricin toxin A-chain subunitPrevention of ricin poisoning · 21/03/2018 · PositiveEMA designation
- EMA ovine polyclonal fragment antigen-binding against ricinTreatment of ricin poisoning · 13/12/2023 · PositiveEMA designation
- EMA Equine polyclonal immunoglobulin F(ab')2 fragments against ricinTreatment of ricin poisoning · 22/05/2025 · WithdrawnEMA designation
Sources: FDA OOPD · EMA orphan designations
Open Targets candidates
No drugs or clinical candidates returned for this Mondo ID on Open Targets.
CTD chemicals (MyDisease.info)
No CTD chemical associations returned for this Mondo ID.
Literature
Is anyone studying this?
175
175 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.
175 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).
76 in the last 10 years · high confidence · 53.6th percentile (publications denominator)
Phrase hits: 175 · MeSH hits: 0
Who's working on it?
695
Distinct author names in 175 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Falach R8 papers · 2025
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, 19 Reuven Lerer St., Ness-Ziona, 76100, Israel. reutf@iibr.gov.il.
Papers in Europe PMC - 02Kronman C7 papers · 2022
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100, Israel. chanochk@iibr.gov.il.
Papers in Europe PMC - 03Sapoznikov A7 papers · 2025
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, 19 Reuven Lerer St., Ness-Ziona, 76100, Israel.
Papers in Europe PMC - 04Evgy Y6 papers · 2025
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, 19 Reuven Lerer St., Ness-Ziona, 76100, Israel.
Papers in Europe PMC - 05Gal Y6 papers · 2022
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, 19 Reuven Lerer St., Ness-Ziona, 76100, Israel.
Papers in Europe PMC - 06Sabo T6 papers · 2022
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, 19 Reuven Lerer St., Ness-Ziona, 76100, Israel.
Papers in Europe PMC - 07Aftalion M5 papers · 2025
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, 19 Reuven Lerer St., Ness-Ziona, 76100, Israel.
Papers in Europe PMC - 08Avril A5 papers · 2026
Microbiology and Infectious Diseases Department, Anti-Infectious Biotherapies and Immunity Unit, Army Biomedical Research Institute, 91220 Brétigny-sur-Orge, France.
Papers in Europe PMC - 09Dorner BG5 papers · 2025
Biological Toxins, Centre for Biological Threats and Special Pathogens, Robert Koch Institute, 13353 Berlin, Germany. dornerb@rki.de.
Papers in Europe PMC - 10Griffiths GD5 papers · 2011
Biology Department, Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 0JQ, UK. gdgriffiths@dstl.gov.uk
Papers in Europe PMC
Clinical research
Is a treatment being tested?
3
interventional trials for this specific condition
3 interventional trials matched this specific condition name; none in our sample are currently recruiting. 119 trials are registered for poisoning, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 11 September 2026
3 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 86.7th percentile).
high confidence · 86.7th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
3 interventional trials matched after quoted-phrase search and title/condition post-filter.
No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.
Broader category: poisoning
119
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT06811675·RECRUITING·The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning
Not reviewed·Conditions: Carbon Monoxide Poisoning · Delayed Neurocognitive Sequelae·Matched via name phrase
- NCT07103356·RECRUITING·Table-Top Water Pitcher to Reduce Arsenic Exposure Among Well Users in New Hampshire
Not reviewed·Conditions: Arsenic Poisoning · Environmental Exposure · Water-Related Diseases·Matched via name phrase
- NCT07234383·NOT YET RECRUITING·Accelerated HEmodiafiltration in Severe Acute Diquat (AHEAD) Poisoning
Not reviewed·Conditions: Diquat Poisoning·Matched via name phrase
- NCT07201311·RECRUITING·Combined Gastrointestinal Decontamination in Acute Severe Poisoning
Not reviewed·Conditions: Severe Poisoning With Cardiotropic or Psychotropic Drug · Admission to Intensive Care·Matched via name phrase
- NCT07459166·RECRUITING·A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade
Not reviewed·Conditions: Fentanyl Overdose · Fentanyl Poisoning·Matched via name phrase
- NCT04499885·RECRUITING·Potential Role of Gastric Lavage by Paraffin Oil in Acute Aluminum Phosphide Poisoning
Not reviewed·Conditions: Toxicity, Drug·Matched via name phrase
- NCT06574048·NOT YET RECRUITING·Carbon Monoxide Hyperbaric Oxygen With Steroid Therapy
Not reviewed·Conditions: Carbon Monoxide Poisoning · Carbon Monoxide Intoxication · Carbon Monoxide Encephalopathy · Carbon Monoxide-induced Parkinsonism·Matched via name phrase
- NCT05471479·RECRUITING·Activated CHARcoal in Poisoned Patient - Pilot Trial
Not reviewed·Conditions: Charcoal, Decontamination, Poisoning·Matched via name phrase
- NCT07632937·NOT YET RECRUITING·A Study to Assess the Efficacy of Public Health Campaigns in Reducing Lead Exposure
Not reviewed·Conditions: Lead Poisoning · Environmental Exposure·Matched via name phrase
- NCT06966765·NOT YET RECRUITING·Accelerated vs Standard Approach to Continuous Veno-venous Hemodiafiltration Post-hemoperfusion (ASAP) in Severe Acute Diquat Poisoning
Not reviewed·Conditions: Diquat Poisoning·Matched via name phrase
Other registries (secondary)
Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.
raw 0 · after dedupe 0 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 0 · dropped 0 · fetched 2026-07-30
Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri
No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).
Where to find support
Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.
Orphanet entry for Ricin poisoning — check Associations / patient organisations on that page.
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Ricin poisoning"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Ricin poisoning"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 3 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"poisoning"
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T18:31:52.752Z