ORPHA:563
Peripartum cardiomyopathy
Also known as: Postpartum cardiomyopathy
Publications
4,981
Trials
6
Interventional, condition-specific
Researchers
1,148
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
Peripartum (PPCM) is an , potentially fatal form of dilated that develops during the final month of pregnancy or within five months after delivery.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0018920
- UMLS:C0877208
- NCIT:C171602
Additional Mondo synonyms (2)
peripartum cardiomyopathy · postpartum cardiomyopathy
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
4,981 matched papers (3,332 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
6 matched on ClinicalTrials.gov (2 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
4,981
4,981 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
4,981 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
3,332 in the last 10 years · low confidence
Phrase hits: 4,981 · MeSH hits: 0
Who's working on it?
1,148
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Sliwa K14 papers · 2026
Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Papers in Europe PMC - 02Bauersachs J10 papers · 2026
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Papers in Europe PMC - 03Hoevelmann J6 papers · 2026
Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Papers in Europe PMC - 04van der Meer P5 papers · 2026
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Papers in Europe PMC - 05Viljoen C5 papers · 2026
Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Papers in Europe PMC - 06Chakafana G4 papers · 2026
Department of Chemistry and Biochemistry, Hampton University, Hampton, VA, USA.
Papers in Europe PMC - 07Hilfiker-Kleiner D4 papers · 2026
Institute Cardiovascular Complications in Pregnancy and Oncologic Therapies, Philipps University Marburg, Marburg, Germany.
Papers in Europe PMC - 08Karaye KM4 papers · 2026
Department of Medicine, Bayero University and Aminu Kano Teaching Hospital, Kano, Nigeria.
Papers in Europe PMC - 09
- 10
Clinical research
Is a treatment being tested?
6
interventional trials for this specific condition
6 interventional trials matched this specific condition name; 2 currently recruiting in our sample.
Data as of 27 July 2026
6 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 89th percentile).
low confidence · 89th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
6 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT07334197·NOT YET RECRUITING·Effect of Melatonin on Left Ventricular Reverse Remodeling and Inflammation in Peripartum Cardiomyopathy
Conditions: Ppm, Cardiomyopathy·Matched via name phrase
- NCT05180773·RECRUITING·Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy
Conditions: Peripartum Cardiomyopathy, Postpartum·Matched via name phrase
Observational and natural-history studies
8 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT06607471·RECRUITING·Multimodal and Multidisciplinary Approach to Optimize Diagnostic, Prognostic, and Therapeutic Management of Patients with Non-ischemic Cardiomyopathies and Arrhythmogenic-inflammatory Phenotypes: a Multicenter, Observational, Retrospective and Prospective Registry Study.
Conditions: Non-ischemic Cardiomyopathy · Dilated Cardiomyopathy (DCM) · Hypertrophic Cardiomyopathy (HCM) · Restrictive Cardiomyopathy·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Peripartum cardiomyopathy" OR "Postpartum cardiomyopathy"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Peripartum cardiomyopathy" OR "Postpartum cardiomyopathy"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 6 interventional · 8 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (4981) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-26T14:21:24.182Z