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ORPHA:55881

Adamantinoma

low confidenceDisorder

Also known as: Adamantinoma of long bones

Publications

2,621

Trials

0

Interventional, condition-specific

Researchers

1,158

Distinct authors in sample

Gene link

—

Readiness

1/6

Stages with a signal

Clinical definition (Orphanet)

A rare, primary low-grade malignant bone tumor that occurs in more than 80% of cases on the anterior surface of the tibia (tibial dyaphysis). Most cases are symptomatic or present with pain, swelling, bowing deformity or pathological fracture. Metastases especially in the lungs may be observed.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (6)

Extragnathic adamantinoma · adamantinoma · adamantinoma of long bones · adamantinoma of long bones (morphologic abnormality) · adamantinoma, malignant · long bone adamantinoma

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

1/6 stages with a signal

Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    2,621 matched papers (1,115 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialNot found

    No matched interventional trial under our ClinicalTrials.gov rules

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

2,621

2,621 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

2,621 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

1,115 in the last 10 years · low confidence

Phrase hits: 2,621 · MeSH hits: 59

Open Europe PMC search

Who's working on it?

1,158

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.

  1. 01
    Li Y6 papers · 2026

    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.

    Papers in Europe PMC
  2. 02
    Rekhi B6 papers · 2026

    Department of Surgical Pathology, Tata Memorial Hospital, Parel Homi Bhabha National Institute(HBNI) University, Mumbai, India; Division of Molecular Pathology, Tata Memorial Hospital, Parel Homi Bhabha National Institute(HBNI) University, Mumbai, India. Electronic address: rekhi.bharat@gmail.com.

    Papers in Europe PMC
  3. 03
    Zhang Q6 papers · 2025

    Department of Orthopaedic Oncology Surgery, Beijing Jishuitan Hospital, Peking University, Number 31, Xinjiekoudongjie Street, Xicheng District, Beijing, 100035, China.

    Papers in Europe PMC
  4. 04
    Agaimy A5 papers · 2026

    Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Comprehensive Cancer Center (CCC) Erlangen-EMN, Erlangen, Germany. Abbas.Agaimy@uk-erlangen.de.

    Papers in Europe PMC
  5. 05
    Bishop JA5 papers · 2026

    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.

    Papers in Europe PMC
  6. 06
    Deng Z5 papers · 2025

    Department of Orthopaedic Oncology Surgery, Beijing Jishuitan Hospital, Peking University, Number 31, Xinjiekoudongjie Street, Xicheng District, Beijing, 100035, China.

    Papers in Europe PMC
  7. 07
    Li Z5 papers · 2025

    Department of Orthopaedic Oncology Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.

    Papers in Europe PMC
  8. 08
    Liu W5 papers · 2025

    Department of Orthopaedic Oncology Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China. liuweifengjst@126.com.

    Papers in Europe PMC
  9. 09
    Niu X5 papers · 2025

    Department of Orthopaedic Oncology Surgery, Beijing Jishuitan Hospital, Peking University, Number 31, Xinjiekoudongjie Street, Xicheng District, Beijing, 100035, China. niuxiaohui@263.net.

    Papers in Europe PMC
  10. 10
    Yang Y4 papers · 2025

    Department of Orthopaedic Oncology Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

0

interventional trials for this specific condition

No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).

Data as of 27 July 2026

No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.

low confidence · 36.5th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.

See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Adamantinoma" OR "Adamantinoma of long bones" OR "Adamantinoma of the long bones" OR "Extragnathic adamantinoma" OR "adamantinoma of long bones (morphologic abnormality)" OR "adamantinoma of the long bones (morphologic abnormality)" OR "adamantinoma, malignant" OR "long bone adamantinoma"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: [OBSOLETE] Adamantinoma Of Long Bones; Adamantinoma

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Adamantinoma" OR "Adamantinoma of long bones" OR "Adamantinoma of the long bones" OR "Extragnathic adamantinoma" OR "adamantinoma of long bones (morphologic abnormality)" OR "adamantinoma of the long bones (morphologic abnormality)" OR "adamantinoma, malignant" OR "long bone adamantinoma" OR "[OBSOLETE] Adamantinoma Of Long Bones"

Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is short or not clearly distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (2621) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T00:58:42.305Z