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ORPHA:533

Listeriosis

low confidenceDisorder

Also known as: Listeria infection

Publications

18,969

Trials

2

Interventional, condition-specific

Researchers

1,138

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

A rare bacterial infectious disease caused by the foodborne pathogen Listeria monocytogenes, characterized by a febrile gastroenteritis, which is usually mild and self-limiting in otherwise healthy persons, but can progress to severe illness in at-risk groups like pregnant women, elderly people, immunocompromised people, and neonates. Complications include sepsis, meningitis, and encephalitis. Listeriosis during pregnancy usually occurs during the third trimester and may lead to preterm labor, miscarriage, stillbirth, or intrauterine infection of the unborn child.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (4)

Listeria monocytogenes caused disease or disorder · Listeria monocytogenes disease or disorder · Listeria monocytogenes infectious disease · infection by Listeria monocytogenes

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    18,969 matched papers (6,794 in last 10 years) Source

  3. Phenotype characterisedPresent

    67 HPO annotations (e.g. Unusual CNS infection; Fatigue; Chills) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    2 matched on ClinicalTrials.gov (1 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

67

Associated phenotypes · MONDO:0005828

  • Unusual CNS infection
  • Fatigue
  • Chills
  • Stiff neck
  • Bacteremia

Showing 5 of 67 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-27

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

1

Drugs / clinical candidates · MONDO_0005828

CTD chemicals (MyDisease.info)

3 associated chemicals · 76 pathways. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • telavancin · therapeutic
  • Benzene · marker/mechanism
  • Temozolomide · marker/mechanism

Pathways: Antifolate resistance; MAPK signaling pathway; Cytokine-cytokine receptor interaction; NF-kappa B signaling pathway; Sphingolipid signaling pathway; mTOR signaling pathway; Apoptosis; TGF-beta signaling pathway

MyDisease.info · MONDO:0005828

Literature

Is anyone studying this?

18,969

18,969 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

18,969 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

6,794 in the last 10 years · low confidence

Phrase hits: 18,969 · MeSH hits: 425

Open Europe PMC search

Who's working on it?

1,138

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Leclercq A6 papers · 2026

    Institut Pasteur, Listeria National Reference Center and WHO Collaborating Center, Paris, France.

    Papers in Europe PMC
  2. 02
    Li X6 papers · 2026

    Department of Pulmonology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, Gansu, China.

    Papers in Europe PMC
  3. 03
    Yin Y6 papers · 2026

    Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, China; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of China, Yangzhou University, Yangzhou, Jiangsu Province, China; Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu Province, China; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China. Electronic address: yylan@yzu.edu.cn.

    Papers in Europe PMC
  4. 04
    Jiao X5 papers · 2026

    Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, China; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of China, Yangzhou University, Yangzhou, Jiangsu Province, China; Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu Province, China; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China. Electronic address: jiao@yzu.edu.cn.

    Papers in Europe PMC
  5. 05
    Lecuit M5 papers · 2026

    Institut Pasteur, Université Paris Cité, Inserm U1117, Biology of Infection Unit, Paris, France. marc.lecuit@pasteur.fr.

    Papers in Europe PMC
  6. 06
    Wang Y5 papers · 2026

    Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, China; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of China, Yangzhou University, Yangzhou, Jiangsu Province, China; Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu Province, China; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China.

    Papers in Europe PMC
  7. 07
    Halbedel S4 papers · 2026

    FG11 Division of Enteropathogenic Bacteria and Legionella, Consultant Laboratory for Listeria, Robert Koch Institute, Wernigerode, Germany.

    Papers in Europe PMC
  8. 08
    Li Y4 papers · 2026

    Key Laboratory for Experimental Teratology of the Ministry of Education, Advanced Medical Research Institute, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

    Papers in Europe PMC
  9. 09
    Wang Z4 papers · 2026

    College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China.

    Papers in Europe PMC
  10. 10
    Wu Y4 papers · 2026

    College of Life Science and Resources and Environment, Yichun University, Yichun, China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

2

interventional trials for this specific condition

2 interventional trials matched this specific condition name; 1 currently recruiting in our sample.

Data as of 9 September 2026

2 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 84.5th percentile).

low confidence · 84.5th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

2 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

2 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

None of the matched observational studies is currently listed as recruiting.

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 4 · after dedupe 4 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 0 · dropped 4 · fetched 2026-07-27

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Listeriosis — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

("Listeriosis" OR "Listeria infection" OR "Listeria monocytogenes infectious disease" OR "infection by Listeria monocytogenes") OR (MESH:"Listeriosis")

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Listeriosis

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Listeriosis" OR "Listeria infection" OR "Listeria monocytogenes infectious disease" OR "infection by Listeria monocytogenes"

Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 2 interventional · 2 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: Listeria monocytogenes caused disease or disorder; Listeria monocytogenes disease or disorder

Confidence reasoning

  • Preferred label is short or not clearly distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (18969) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-26T01:59:11.342Z