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ORPHA:52417

MALT lymphoma

high confidenceDisorder

Also known as: Extranodal marginal zone B-cell lymphoma · MALToma · Mucosa-associated lymphatic tissue lymphoma · Mucosa-associated lymphoid tissue lymphoma

Publications

19,155

98.5th percentile

Trials

172

Interventional, condition-specific

Researchers

1,040

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

MALT (mucosa-associated lymphoid tissue) lymphoma is a rare form of malignant non-Hodgkin lymphoma that affects B cells and grows at the expense of lymphoid tissue associated with mucous membranes, but also occurs, more rarely, in lymph nodes.

How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (9)

Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue · Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma) · Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue · Immunocytoma · MALT-lymphoma · lymphoma of mucosa-associated lymphoid tissue · lymphoma, MALT, somatic · mucosa-associated lymphatic tissue lymphoma · mucosa-associated lymphoid tissue lymphoma

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    19,155 matched papers (9,712 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    172 matched on ClinicalTrials.gov (15 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

19,155

19,155 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

19,155 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

9,712 in the last 10 years · high confidence · 98.5th percentile (publications denominator)

Phrase hits: 19,155 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,040

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Wang X8 papers · 2026

    Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

    Papers in Europe PMC
  2. 02
    Zhang Y8 papers · 2026

    Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

    Papers in Europe PMC
  3. 03
    Chen J6 papers · 2026

    Department of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, No. 600 Tianhe Road, Guangzhou, 510630, China. chjning@mail.sysu.edu.cn.

    Papers in Europe PMC
  4. 04
    Chen Y6 papers · 2026

    Department of Stomatology, The First Affiliated Hospital of Bengbu Medical College Bengbu, Anhui, P. R. China.

    Papers in Europe PMC
  5. 05
    He Y6 papers · 2026

    Department of Radiation Oncology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, People's Republic of China; Zhejiang University Cancer Center, Hangzhou, Zhejiang 310003, People's Republic of China.

    Papers in Europe PMC
  6. 06
    Li J6 papers · 2026

    Department of Hematology, Lymphoma Center, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

    Papers in Europe PMC
  7. 07
    Raderer M6 papers · 2026

    Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria.

    Papers in Europe PMC
  8. 08
    Wang J6 papers · 2026

    Department of Stomatology, The First Affiliated Hospital of Bengbu Medical College Bengbu, Anhui, P. R. China.

    Papers in Europe PMC
  9. 09
    Kiesewetter B5 papers · 2026

    Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria.

    Papers in Europe PMC
  10. 10
    Liu S5 papers · 2026

    Department of Radiation Oncology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

172

interventional trials for this specific condition

172 interventional trials matched this specific condition name; 15 currently recruiting in our sample.

Data as of 27 July 2026

172 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 99.1th percentile).

high confidence · 99.1th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

172 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

8 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"MALT lymphoma" OR "Extranodal marginal zone B-cell lymphoma" OR "MALToma" OR "Mucosa-associated lymphatic tissue lymphoma" OR "Mucosa-associated lymphoid tissue lymphoma" OR "Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue" OR "Extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue" OR "Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma)" OR "Extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT-lymphoma)" OR "Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue" OR "Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue" OR "Immunocytoma" OR "MALT-lymphoma" OR "lymphoma of mucosa-associated lymphoid tissue" OR "lymphoma of the mucosa-associated lymphoid tissue" OR "lymphoma, MALT, somatic"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"MALT lymphoma" OR "Extranodal marginal zone B-cell lymphoma" OR "MALToma" OR "Mucosa-associated lymphatic tissue lymphoma" OR "Mucosa-associated lymphoid tissue lymphoma" OR "Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue" OR "Extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue" OR "Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma)" OR "Extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT-lymphoma)" OR "Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue" OR "Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue" OR "Immunocytoma" OR "MALT-lymphoma" OR "lymphoma of mucosa-associated lymphoid tissue" OR "lymphoma of the mucosa-associated lymphoid tissue" OR "lymphoma, MALT, somatic"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 172 interventional · 8 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T00:49:04.888Z