ORPHA:521219
Mirizzi syndrome
Also known as: Extrinsic biliary compression syndrome
Publications
1,487
Trials
0
Interventional, condition-specific
Researchers
1,158
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
A rare biliary tract disease characterized by external compression and subsequent obstruction of an extrahepatic biliary duct by one or more gallstones in the cystic duct or the gallbladder. Patients may present with acute or chronic cholecystitis with right upper abdominal pain, nausea, and vomiting, jaundice, or cholangitis. Cholecystobiliary or -enteric fistulae can arise due to chronic inflammation and ulceration.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0043330
- MeSH:D057792
- UMLS:C0267878
Additional Mondo synonyms (1)
mirizzi's syndrome
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
1,487 matched papers (756 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
1,487
1,487 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
1,487 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
756 in the last 10 years · low confidence
Phrase hits: 1,487 · MeSH hits: 61
Who's working on it?
1,158
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Guo J3 papers · 2025
Department of Hepatobiliary and Pancreatic Surgery, Renhe Hospital, Shanghai University, Shanghai, China.
Papers in Europe PMC - 02Hou S3 papers · 2022
The Second Hospital of Hebei Medical University, The Second Hospital of Hebei Medical University, China.
Papers in Europe PMC - 03Li Y3 papers · 2023
Department of Radiology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing 100144, China.
Papers in Europe PMC - 04Adhikari B2 papers · 2024
Infectious Diseases, School of Medicine, University of Louisville, Louisville, USA.
Papers in Europe PMC - 05Ahmad J2 papers · 2026
University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
Papers in Europe PMC - 06Bi JT2 papers · 2023
Department of General Surgery, Beijing Jishuitan Hospital, Beijing, 100035, China.
Papers in Europe PMC - 07Bruno MJ2 papers · 2025
Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, the Netherlands.
Papers in Europe PMC - 08Cai X2 papers · 2023
Department of General Surgery, Beijing Jishuitan Hospital, Beijing, 100035, China.
Papers in Europe PMC - 09Ekingen E2 papers · 2026
Department of Emergency Medicine, Etimesgut Sehit Sait Erturk State Hospital, Ankara 06790, Turkey.
Papers in Europe PMC - 10Gerges C2 papers · 2025
Department of Gastroenterology and General Internal Medicine, HMU University Campus, Helios Clinic Krefeld, Krefeld, Germany.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name. 1 observational study did — shown below because natural-history and cohort work can be an important step toward a trial.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
low confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Observational and natural-history studies
1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Mirizzi syndrome" OR "Extrinsic biliary compression syndrome" OR "mirizzi's syndrome"
MeSH descriptor terms unioned into the query: Mirizzi Syndrome
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Mirizzi syndrome" OR "Extrinsic biliary compression syndrome" OR "mirizzi's syndrome"
Study-type breakdown: 0 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is short or not clearly distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (1487) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-27T18:01:55.661Z