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ORPHA:51890

Anterior cutaneous nerve entrapment syndrome

low confidenceDisorder

Also known as: ACNES · Intercostal nerve syndrome · Rectus abdominis syndrome

Publications

21,761

Trials

16

Interventional, condition-specific

Researchers

995

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

A chronic neuropathic pain syndrome of the abdominal wall caused by entrapment of anterior cutaneous branches of 7 to 12th intercostal nerves along the lateral border of the anterior rectus abdominis fascia causing severe pain and tenderness of the involved dermatome.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (2)

intercostal nerve syndrome · rectus abdominis syndrome

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    21,761 matched papers (13,050 in last 10 years) Source

  3. Phenotype characterisedPresent

    17 HPO annotations (e.g. Hyperhidrosis; Anorexia; Impaired tactile sensation) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    16 matched on ClinicalTrials.gov (5 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

17

Associated phenotypes · MONDO:0018873

  • Hyperhidrosis
  • Anorexia
  • Impaired tactile sensation
  • Increased total leukocyte count
  • Nausea

Showing 5 of 17 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

21,761

21,761 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

21,761 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

13,050 in the last 10 years · low confidence

Phrase hits: 21,761 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

995

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Roumen RMH10 papers · 2026

    Department of Surgery, Máxima Medical Center, Eindhoven/Veldhoven, The Netherlands.

    Papers in Europe PMC
  2. 02
    Scheltinga MRM10 papers · 2026

    Department of Surgery, Máxima Medical Center, Eindhoven/Veldhoven, The Netherlands.

    Papers in Europe PMC
  3. 03
    Jacobs MLYE7 papers · 2026

    Department of Surgery, Máxima Medical Center, Eindhoven/Veldhoven, The Netherlands.

    Papers in Europe PMC
  4. 04
    Watari T7 papers · 2026

    Shimane University Faculty of Medicine Graduate School of Medicine, Izumo, Shimane, Japan wataritari@gmail.com.

    Papers in Europe PMC
  5. 05
    Zwaans WAR5 papers · 2026

    Department of Surgery, Máxima Medical Center, Veldhoven, The Netherlands.

    Papers in Europe PMC
  6. 06
    Chen J4 papers · 2026

    Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

    Papers in Europe PMC
  7. 07
    Ten Have T4 papers · 2025

    Department of Surgery, Máxima Medical Centre, De Run 4600, P.O. Box 7777, 5500 MB, Eindhoven/Veldhoven, The Netherlands.

    Papers in Europe PMC
  8. 08
    Wang H4 papers · 2026

    Department of Radiological intervention, Tianjin First Central Hospital, Tianjin 300192, China.

    Papers in Europe PMC
  9. 09
    Zhang M4 papers · 2026

    Faculty of Information Engineering and Automation, Kunming University of Science and Technology, Kunming, 650031, China.

    Papers in Europe PMC
  10. 10
    Gerdes VEA3 papers · 2026

    Department of Bariatric Surgery, Sparano Gasthuis, Spaarnepoort 1, 2134 TM, Hoofddorp, The Netherlands.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

16

interventional trials for this specific condition

16 interventional trials matched this specific condition name; 5 currently recruiting in our sample.

Data as of 11 September 2026

16 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 94.2th percentile).

low confidence · 94.2th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

16 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

4 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 8 · after dedupe 8 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 8 · dropped 0 · fetched 2026-07-29

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (8)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Anterior cutaneous nerve entrapment syndrome — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Anterior cutaneous nerve entrapment syndrome" OR "ACNES" OR "Intercostal nerve syndrome" OR "Rectus abdominis syndrome"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Anterior cutaneous nerve entrapment syndrome" OR "ACNES" OR "Intercostal nerve syndrome" OR "Rectus abdominis syndrome"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 16 interventional · 4 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (21761) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T00:47:04.395Z