ORPHA:506075
Non-functioning neuroendocrine tumor of pancreas
Also known as: Non-functioning PNET · Non-functioning pancreatic NET · Non-functioning pancreatic neuroendocrine tumor · Non-functioning well-differentiated NEN of pancreas · Non-functioning well-differentiated neuroendocrine neoplasm of pancreas · Non-functioning well-differentiated pancreatic NEN · Non-functioning well-differentiated pancreatic neuroendocrine neoplasm
Publications
261
66.8th percentile
Trials
6
Interventional, condition-specific
Researchers
1,291
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A rare neuroendocrine tumor of pancreas characterized by a well-differentiated epithelial pancreatic neuroendocrine neoplasm measuring at least 0.5 cm, without distinct hormonal syndrome. Tumors <0.5 cm are called microadenomas. Microadenomatosis is the multifocal occurrence of microadenomas. Histopathologic examination shows an organoid growth pattern and expression of synaptophysin and chromogranin A on immunohistochemistry. Tumors are often discovered incidentally, or patients may present with symptoms related to local or metastatic tumor spread. Microadenomas are considered benign, while larger tumors may behave in a malignant manner with extrapancreatic spread, metastasis, or recurrence.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0004334
- MeSH:C536126
- UMLS:C1334977
- NCIT:C45837
Additional Mondo synonyms (25)
inactive pancreatic endocrine tumor · inactive pancreatic endocrine tumour · non-functional pancreatic neuroendocrine tumor · non-functioning PNET · non-functioning pancreatic NET · non-functioning pancreatic endocrine tumor · non-functioning pancreatic endocrine tumour · non-functioning pancreatic neuroendocrine tumor · non-functioning pancreatic neuroendocrine tumour · non-functioning well differentiated pancreatic endocrine tumor · non-functioning well differentiated pancreatic endocrine tumour · non-functioning well-differentiated NEN of pancreas · non-functioning well-differentiated neuroendocrine neoplasm of pancreas · non-functioning well-differentiated pancreatic NEN · non-functioning well-differentiated pancreatic neuroendocrine neoplasm · non-syndromic pancreatic NET · non-syndromic pancreatic neuroendocrine tumor · non-syndromic pancreatic neuroendocrine tumour · nonfunctional pancreatic NET · nonfunctional pancreatic neuroendocrine tumor · nonfunctional pancreatic neuroendocrine tumour · nonsyndromic pancreatic endocrine tumor · nonsyndromic pancreatic endocrine tumour · nonsyndromic pancreatic neuroendocrine tumor · nonsyndromic pancreatic neuroendocrine tumour
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
261 matched papers (185 in last 10 years) Source
- Phenotype characterisedNot found
No HPO disease–phenotype associations via Monarch for these Mondo IDs
- Animal modelNot found
No Alliance genotype “model of” associations via Monarch for these Mondo IDs
- Orphan designationNot found
No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source
- Interventional trialPresent
6 matched on ClinicalTrials.gov
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
None returned for this Mondo ID. That often means “not linked under this ID,” not “no clinical features.”
Animal models (Monarch / Alliance)
None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.
Monarch fetch 2026-07-29
Therapies
Designations, candidates, and chemicals
FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.
Orphan designation (FDA · EMA)
No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.
Open Targets candidates
No drugs or clinical candidates returned for this Mondo ID on Open Targets.
CTD chemicals (MyDisease.info)
No CTD chemical associations returned for this Mondo ID.
Literature
Is anyone studying this?
261
261 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.
261 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).
185 in the last 10 years · high confidence · 66.8th percentile (publications denominator)
Phrase hits: 261 · MeSH hits: 0
Who's working on it?
1,291
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01
- 02Bian Y7 papers · 2022
Department of Radiology, Changhai Hospital, Shanghai, China.
Papers in Europe PMC - 03
- 04Cao K5 papers · 2022
Department of Radiology, Changhai Hospital, Shanghai, China.
Papers in Europe PMC - 05Fang X5 papers · 2022
Department of Radiology, Changhai Hospital, Shanghai, China.
Papers in Europe PMC - 06Jiang H5 papers · 2022
Department of Pathology, Changhai Hospital, Shanghai, China.
Papers in Europe PMC - 07
- 08Wang Y5 papers · 2024
Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Papers in Europe PMC - 09Han X4 papers · 2023
Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Papers in Europe PMC - 10Wang L4 papers · 2022
Department of Radiology, Changhai Hospital, Shanghai, China.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
6
interventional trials for this specific condition
6 interventional trials matched this specific condition name; none in our sample are currently recruiting.
Data as of 11 September 2026
6 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 90.1th percentile).
high confidence · 90.1th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
6 interventional trials matched after quoted-phrase search and title/condition post-filter.
No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.
Observational and natural-history studies
3 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Other registries (secondary)
Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.
raw 0 · after dedupe 0 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 0 · dropped 0 · fetched 2026-07-30
Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri
No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).
Where to find support
Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.
Orphanet entry for Non-functioning neuroendocrine tumor of pancreas — check Associations / patient organisations on that page.
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Non-functioning neuroendocrine tumor of pancreas" OR "Non-functioning neuroendocrine tumor of the pancreas" OR "Non-functioning PNET" OR "Non-functioning pancreatic NET" OR "Non-functioning pancreatic neuroendocrine tumor" OR "Non-functioning well-differentiated NEN of pancreas" OR "Non-functioning well-differentiated NEN of the pancreas" OR "Non-functioning well-differentiated neuroendocrine neoplasm of pancreas" OR "Non-functioning well-differentiated neuroendocrine neoplasm of the pancreas" OR "Non-functioning well-differentiated pancreatic NEN" OR "Non-functioning well-differentiated pancreatic neuroendocrine neoplasm" OR "inactive pancreatic endocrine tumor" OR "inactive pancreatic endocrine tumour" OR "non-functional pancreatic neuroendocrine tumor" OR "non-functioning pancreatic endocrine tumor" OR "non-functioning pancreatic endocrine tumour" OR "non-functioning pancreatic neuroendocrine tumour" OR "non-functioning well differentiated pancreatic endocrine tumor" OR "non-functioning well differentiated pancreatic endocrine tumour" OR "non-syndromic pancreatic NET" OR "non-syndromic pancreatic neuroendocrine tumor" OR "non-syndromic pancreatic neuroendocrine tumour" OR "nonfunctional pancreatic NET" OR "nonfunctional pancreatic neuroendocrine tumor" OR "nonfunctional pancreatic neuroendocrine tumour" OR "nonsyndromic pancreatic endocrine tumor" OR "nonsyndromic pancreatic endocrine tumour" OR "nonsyndromic pancreatic neuroendocrine tumor" OR "nonsyndromic pancreatic neuroendocrine tumour"
MeSH descriptor terms unioned into the query: Non functioning pancreatic endocrine tumor
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Non-functioning neuroendocrine tumor of pancreas" OR "Non-functioning neuroendocrine tumor of the pancreas" OR "Non-functioning PNET" OR "Non-functioning pancreatic NET" OR "Non-functioning pancreatic neuroendocrine tumor" OR "Non-functioning well-differentiated NEN of pancreas" OR "Non-functioning well-differentiated NEN of the pancreas" OR "Non-functioning well-differentiated neuroendocrine neoplasm of pancreas" OR "Non-functioning well-differentiated neuroendocrine neoplasm of the pancreas" OR "Non-functioning well-differentiated pancreatic NEN" OR "Non-functioning well-differentiated pancreatic neuroendocrine neoplasm" OR "inactive pancreatic endocrine tumor" OR "inactive pancreatic endocrine tumour" OR "non-functional pancreatic neuroendocrine tumor" OR "non-functioning pancreatic endocrine tumor" OR "non-functioning pancreatic endocrine tumour" OR "non-functioning pancreatic neuroendocrine tumour" OR "non-functioning well differentiated pancreatic endocrine tumor" OR "non-functioning well differentiated pancreatic endocrine tumour" OR "non-syndromic pancreatic NET" OR "non-syndromic pancreatic neuroendocrine tumor" OR "non-syndromic pancreatic neuroendocrine tumour" OR "nonfunctional pancreatic NET" OR "nonfunctional pancreatic neuroendocrine tumor" OR "nonfunctional pancreatic neuroendocrine tumour" OR "nonsyndromic pancreatic endocrine tumor" OR "nonsyndromic pancreatic endocrine tumour" OR "nonsyndromic pancreatic neuroendocrine tumor" OR "nonsyndromic pancreatic neuroendocrine tumour" OR "Non functioning pancreatic endocrine tumor"
Interventional trials matched via: both, phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 6 interventional · 3 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T17:50:35.453Z