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ORPHA:48104

Pyoderma gangrenosum

low confidenceDisorder

Publications

9,388

Trials

28

Interventional, condition-specific

Researchers

966

Distinct authors in sample

Gene link

—

Readiness

4/6

Stages with a signal

Clinical definition (Orphanet)

A rare inflammatory neutrophilic dermatosis characterized by painful cutaneous ulcerations with a violaceous and undermined border affecting the lower extremities; however, any hair-bearing area can be affected.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

4/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    9,388 matched papers (5,251 in last 10 years) Source

  3. Phenotype characterisedPresent

    15 HPO annotations (e.g. Papule; Atrophic scars; Rheumatoid arthritis) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationPresent

    1 FDA · 1 EMA designations (1 FDA orphan-indication approval) — e.g. gevokizumab Source

  6. Interventional trialPresent

    28 matched on ClinicalTrials.gov (5 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

15

Associated phenotypes · MONDO:0018824

  • Papule
  • Atrophic scars
  • Rheumatoid arthritis
  • Fever
  • Abnormal blistering of the skin

Showing 5 of 15 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

2

Designations · 1 with FDA orphan-indication approval

  • FDA gevokizumabPyoderma Gangrenosum · 2014-02-21 · Not FDA Approved for Orphan Indication
  • EMA vilobelimabTreatment of pyoderma gangrenosum · 18/07/2022 · PositiveEMA designation

Sources: FDA OOPD · EMA orphan designations

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

6 associated chemicals · 42 pathways. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • Adrenal Cortex Hormones · therapeutic
  • Clofazimine · therapeutic
  • Silver Sulfadiazine · therapeutic
  • Tacrolimus · therapeutic
  • Thalidomide · therapeutic
  • Cocaine · marker/mechanism

Pathways: NOD-like receptor signaling pathway; TNF signaling pathway; Shigellosis; Pertussis; Tuberculosis; Influenza A; Inflammatory bowel disease (IBD); Cytokine Signaling in Immune system

MyDisease.info · MONDO:0018824

Literature

Is anyone studying this?

9,388

9,388 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

9,388 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

5,251 in the last 10 years · low confidence

Phrase hits: 9,388 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

966

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Ortega-Loayza AG13 papers · 2026

    Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA.

    Papers in Europe PMC
  2. 02
    Marzano AV7 papers · 2026

    Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

    Papers in Europe PMC
  3. 03
    Zhang R5 papers · 2026

    Department of Dermatology, The Second Affiliated Hospital of Wannan Medical University, Wuhu 241000, China.

    Papers in Europe PMC
  4. 04
    Dissemond J4 papers · 2026

    Department of Dermatology, Venerology and Allergology, University Hospital Essen, Essen, Germany.

    Papers in Europe PMC
  5. 05
    Downey K4 papers · 2026

    Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA and.

    Papers in Europe PMC
  6. 06
    Gillespie J4 papers · 2026

    Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA and.

    Papers in Europe PMC
  7. 07
    Latour E4 papers · 2026

    Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA; Biostatistics Shared Resource, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.

    Papers in Europe PMC
  8. 08
    Roland-McGowan J4 papers · 2026

    Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA and.

    Papers in Europe PMC
  9. 09
    Bardazzi F3 papers · 2026

    IRCCS Azienda Ospedaliero‐Universitaria di Bologna

    Papers in Europe PMC
  10. 10
    Dini V3 papers · 2026

    Department of Dermatology, University of Pisa, Pisa, Italy.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

28

interventional trials for this specific condition

28 interventional trials matched this specific condition name; 5 currently recruiting in our sample. 2 trials are registered for pyoderma, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 11 September 2026

28 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 95.8th percentile).

low confidence · 95.8th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

28 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: pyoderma

2

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Observational and natural-history studies

4 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

None of the matched observational studies is currently listed as recruiting.

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 9 · after dedupe 9 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 9 · dropped 0 · fetched 2026-07-29

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (9)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Pyoderma gangrenosum — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Pyoderma gangrenosum"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Pyoderma gangrenosum"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 28 interventional · 4 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"pyoderma"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (9388) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T00:13:44.200Z