RARE DISEASERESEARCH ATLAS
Open navigation menu

ORPHA:47612

Felty syndrome

low confidenceDisorder

Also known as: Splenomegaly-neutropenia-rheumatoid arthritis syndrome

Publications

1,845

Trials

1

Interventional, condition-specific

Researchers

917

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, and neutropenia, resulting in susceptibility to bacterial infections.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (3)

Felty's syndrome · rheumatoid arthritis with splenoadenomegaly and leukopenia · splenomegaly-neutropenia-rheumatoid arthritis syndrome

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    1,845 matched papers (325 in last 10 years) Source

  3. Phenotype characterisedPresent

    40 HPO annotations (e.g. Arthritis; Limitation of joint mobility; Subcutaneous nodule) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    1 matched on ClinicalTrials.gov

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

40

Associated phenotypes · MONDO:0007603

  • Arthritis
  • Limitation of joint mobility
  • Subcutaneous nodule
  • Pericarditis
  • Splenomegaly

Showing 5 of 40 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

1 associated chemical. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • Lithium Carbonate · therapeutic

MyDisease.info · MONDO:0007603

Literature

Is anyone studying this?

1,845

1,845 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

1,845 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

325 in the last 10 years · low confidence

Phrase hits: 1,845 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

917

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Loughran TP Jr7 papers · 2024

    University of Virginia Cancer Center, University of Virginia School of Medicine, Charlottesville, VA, United States.

    Papers in Europe PMC
  2. 02
    Gorodetskiy V4 papers · 2024

    V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.

    Papers in Europe PMC
  3. 03
    Sudarikov A4 papers · 2024

    Laboratory of Molecular Hematology, National Medical Research Center for Hematology, Moscow, Russia.

    Papers in Europe PMC
  4. 04
    Ryzhikova N3 papers · 2024

    Laboratory of Molecular Hematology, National Medical Research Center for Hematology, Moscow, Russia.

    Papers in Europe PMC
  5. 05
    Sidorova Y3 papers · 2024

    Laboratory of Molecular Hematology, National Medical Research Center for Hematology, Moscow, Russia.

    Papers in Europe PMC
  6. 06
    Andrade F2 papers · 2024

    Division of Rheumatology, The Johns Hopkins School of Medicine, Baltimore, MD, United States.

    Papers in Europe PMC
  7. 07
    Bernheim J2 papers · 2007
    Papers in Europe PMC
  8. 08
    Biderman B2 papers · 2024

    Laboratory of Molecular Hematology, National Medical Research Center for Hematology, Moscow, Russia.

    Papers in Europe PMC
  9. 09
    Darrah E2 papers · 2024

    Division of Rheumatology, The Johns Hopkins School of Medicine, Baltimore, MD, United States.

    Papers in Europe PMC
  10. 10
    Doria A2 papers · 2025

    Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

1

interventional trials for this specific condition

1 interventional trial matched this specific condition name; none in our sample are currently recruiting.

Data as of 11 September 2026

1 interventional trial — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 80.1th percentile).

low confidence · 80.1th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

1 interventional trials matched after quoted-phrase search and title/condition post-filter.

No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 4 · after dedupe 4 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 4 · dropped 0 · fetched 2026-07-29

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (4)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Felty syndrome — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Felty syndrome" OR "Splenomegaly-neutropenia-rheumatoid arthritis syndrome" OR "Felty's syndrome" OR "rheumatoid arthritis with splenoadenomegaly and leukopenia"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Felty syndrome" OR "Splenomegaly-neutropenia-rheumatoid arthritis syndrome" OR "Felty's syndrome" OR "rheumatoid arthritis with splenoadenomegaly and leukopenia"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 1 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is short or not clearly distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (1845) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T00:13:20.454Z