ORPHA:458718
Idiopathic spontaneous coronary artery dissection
Also known as: Idiopathic SCAD
Publications
33
32th percentile
Trials
1
Interventional, condition-specific
Researchers
174
Distinct authors in sample
Gene link
TLN1, TSR1
Moderate
Readiness
3/6
Stages with a signal
Clinical definition (Orphanet)
A rare vascular disease characterized by detachment of the layers of the walls of coronary arteries, creating a false lumen which limits the main coronary flow, leading to myocardial ischemia. Clinical manifestations include acute coronary syndromes, especially ST-segment elevation myocardial infarction (STEMI), syncope, cardiogenic shock, or sudden cardiac death. The condition typically affects young women.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0007385
- MeSH:C565153
- OMIM:122455
- UMLS:C1852540
Additional Mondo synonyms (1)
idiopathic SCAD
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
3/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedPresent
Moderate — TLN1, TSR1
- LiteraturePresent
33 matched papers (14 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
1 matched on ClinicalTrials.gov
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Probably — there is moderate evidence for TLN1, TSR1.
GenCC classification: Moderate.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
33
33 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
33 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
14 in the last 10 years · high confidence · 32th percentile (publications denominator)
Phrase hits: 30 · MeSH hits: 3
Who's working on it?
174
Distinct author names in 33 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Saw J2 papers · 2023
Division of Cardiology, Vancouver General Hospital, University of British Columbia, Vancouver, BC V5Z1M9, Canada.
Papers in Europe PMC - 02Abraham K1 paper · 2026
Stony Brook University Hospital, Stony Brook, New York, USA.
Papers in Europe PMC - 03Ahmed A1 paper · 2026
Bridgeport Hospital, Yale New Haven Health, Bridgeport, CT, USA.
Papers in Europe PMC - 04
- 05Aleksandrić S1 paper · 2024
Medical Faculty, University of Belgrade, Belgrade, Serbia.
Papers in Europe PMC - 06Almenar L1 paper · 2009Papers in Europe PMC
- 07
- 08Amini SM1 paper · 2015
Department of Heart, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Papers in Europe PMC - 09Ammann P1 paper · 2005Papers in Europe PMC
- 10Angehrn W1 paper · 2005Papers in Europe PMC
Clinical research
Is a treatment being tested?
1
interventional trials for this specific condition
1 interventional trial matched this specific condition name; none in our sample are currently recruiting.
Data as of 27 July 2026
1 interventional trial — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 76.8th percentile).
high confidence · 76.8th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
1 interventional trials matched after quoted-phrase search and title/condition post-filter.
No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.
Observational and natural-history studies
1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT03398850·RECRUITING·Spontaneous Coronary Artery Dissection anaLysIs of the Brazilian Updated Registry
Conditions: Coronary Artery Dissection, Spontaneous·Matched via MeSH
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Idiopathic spontaneous coronary artery dissection" OR "Idiopathic SCAD"
MeSH descriptor terms unioned into the query: Coronary Artery Dissection, Spontaneous
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Idiopathic spontaneous coronary artery dissection" OR "Idiopathic SCAD" OR "Coronary Artery Dissection, Spontaneous" OR "TLN1" OR "TSR1"
Recall-expansion terms: TLN1, TSR1
Interventional trials matched via: mesh (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 1 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, mesh, recall-expansion; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T16:52:00.650Z