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ORPHA:440368

Necrotizing soft tissue infection

low confidenceDisorder

Also known as: NSTI

Publications

1,569

Trials

8

Interventional, condition-specific

Researchers

983

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare infectious disease characterized by painful, rapidly infection of deep soft tissue structures. Infections can be mono- or polymicrobial and involve gram-positive cocci, enteric gram-negative bacilli, anaerobes, among others. Fungal infections have also been described in rare cases. Physical examination findings are often subtle and may include erythema, bullae, induration of subcutaneous tissues, and tenderness to palpation.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    1,569 matched papers (1,216 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    8 matched on ClinicalTrials.gov (3 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

1,569

1,569 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

1,569 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

1,216 in the last 10 years · low confidence

Phrase hits: 1,569 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

983

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Wang X5 papers · 2026

    Department of Anorectal Surgery, The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.

    Papers in Europe PMC
  2. 02
    Inaba K4 papers · 2026

    Division of Acute Care Surgery, Los Angeles General Medical Center, University of Southern California, Los Angeles, CA, USA.

    Papers in Europe PMC
  3. 03
    Coimbra R3 papers · 2026

    Division of Trauma and Acute Care Surgery, Riverside University Health System Medical Center, Moreno Valley, CA, USA.

    Papers in Europe PMC
  4. 04
    Kashimoto T3 papers · 2026

    Laboratory of Veterinary Public Health, School of Veterinary Medicine, Kitasato University, Aomori, Japan.

    Papers in Europe PMC
  5. 05
    Kim D3 papers · 2026

    Department of Surgery, Victoria General Hospital, Victoria, BC, Canada.

    Papers in Europe PMC
  6. 06
    Tonosaki Y3 papers · 2026

    Laboratory of Veterinary Public Health, School of Veterinary Medicine, Kitasato University, Aomori, Japan.

    Papers in Europe PMC
  7. 07
    Wang L3 papers · 2026

    Department of Medical, Southeast University, 87 Dingjiaqiao street, Nanjing, Jiangsu Province, China.

    Papers in Europe PMC
  8. 08
    Yamazaki K3 papers · 2026

    Laboratory of Veterinary Public Health, School of Veterinary Medicine, Kitasato University, Aomori, Japan.

    Papers in Europe PMC
  9. 09
    Alexander J2 papers · 2026

    Division of Trauma and Critical Care, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

    Papers in Europe PMC
  10. 10
    Alvarez C2 papers · 2026

    Department of Surgery, Division of Division of Trauma, Burns and Surgical Critical Care, University of California Irvine, Orange, CA, USA.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

8

interventional trials for this specific condition

8 interventional trials matched this specific condition name; 3 currently recruiting in our sample.

Data as of 27 July 2026

8 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 90.6th percentile).

low confidence · 90.6th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

8 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

10 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Necrotizing soft tissue infection"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Necrotizing soft tissue infection"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 8 interventional · 10 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: NSTI

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (1569) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T16:20:49.523Z