ORPHA:439762
Systemic polyarteritis nodosa
Also known as: Systemic PAN · Systemic periarteritis nodosa
Query health: suspect — Only one of 2 strategies returned hits (phrase).
Publications
363
78.1th percentile
Trials
0
Interventional, condition-specific
Researchers
1,262
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
Systemic polyarteritis nodosa (PAN) is a chronic systemic necrotizingvasculitis of adults and childrenaffecting small- and medium-sized vessels and characterized by formation of microaneurysms leading to serious generalized disease and multi-organ involvement.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0018596
- UMLS:C5848156
Additional Mondo synonyms (2)
systemic PAN · systemic periarteritis nodosa
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
363 matched papers (193 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPartial
None under the specific name; 9 for broader category polyarteritis nodosa
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
363
363 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
363 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
193 in the last 10 years · high confidence · 78.1th percentile (publications denominator)
Phrase hits: 363 · MeSH hits: 0
Who's working on it?
1,262
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Guillevin L7 papers · 2023
Department of Internal Medicine, Hôpital Avicenne, Bobigny, France.
Papers in Europe PMC - 02Lee S5 papers · 2022
Department of Paediatrics, Seoul National University Children's Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea. leadethme@naver.com.
Papers in Europe PMC - 03Li Y5 papers · 2026
Department of Kidney Transplantation, Second Xiangya Hospital of Central South University, Changsha, China.
Papers in Europe PMC - 04Criado PR4 papers · 2020
Dermatology Division, Hospital das Clínicas da Faculdade de Medicina de São Paulo (HC-FMUSP), São Paulo, São Paulo, Brazil. Electronic address: prcriado@uol.com.br.
Papers in Europe PMC - 05Grayson PC4 papers · 2024
The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA.
Papers in Europe PMC - 06Merkel PA4 papers · 2024
Divison of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.
Papers in Europe PMC - 07Pagnoux C4 papers · 2024
Division of Rheumatology, Mount Sinai Hospital, Toronto, Ontario, Canada.
Papers in Europe PMC - 08
- 09
- 10
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present). 9 trials are registered for polyarteritis nodosa, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
9 interventional trials matched polyarteritis nodosa, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: polyarteritis nodosa
9
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT02939573·RECRUITING·A Randomized Multicenter Study for Isolated Skin Vasculitis
Conditions: Primary Cutaneous Vasculitis · Cutaneous Polyarteritis Nodosa · IgA Vasculitis · Henoch-Schönlein Purpura·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Systemic polyarteritis nodosa" OR "Systemic PAN" OR "Systemic periarteritis nodosa"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Systemic polyarteritis nodosa" OR "Systemic PAN" OR "Systemic periarteritis nodosa" OR "primary polyarteritis nodosa"
Recall-expansion terms: primary polyarteritis nodosa
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"polyarteritis nodosa"
Query health: suspect — strategies attempted: phrase, recall-expansion; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T16:19:13.885Z