ORPHA:439167
Placental insufficiency
Also known as: Uteroplacental vascular insufficiency
Publications
12,359
98.2th percentile
Trials
8
Interventional, condition-specific
Researchers
1,157
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A rare obstetric disease characterized by inadequate blood flow to the placenta during pregnancy, resulting in a decrease in trans-placental transfer of oxygen and nutrients to the fetus, potentially leading to fetal growth retardation, distress, or death. Maternal risk factors include preeclampsia, gestational diabetes, and smoking, among others.
How rare: 1-5 / 10 000 — about one to five people per ten thousand (still uncommon, but less ultra-rare).
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0005919
- MeSH:D010927
- UMLS:C0032051
Additional Mondo synonyms (1)
uteroplacental vascular insufficiency
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
12,359 matched papers (7,439 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
8 matched on ClinicalTrials.gov (2 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
12,359
12,359 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
12,359 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
7,439 in the last 10 years · high confidence · 98.2th percentile (publications denominator)
Phrase hits: 12,359 · MeSH hits: 388
Who's working on it?
1,157
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Brown LD6 papers · 2026
Department of Pediatrics, Section of Neonatology, Perinatal Research Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Papers in Europe PMC - 02Espino-Y-Sosa S5 papers · 2026
Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City, Mexico.
Papers in Europe PMC - 03Rojas-Zepeda L5 papers · 2026
Maternal-Fetal Department, Instituto Materno Infantil del Estado de Mexico, Toluca, Mexico.
Papers in Europe PMC - 04Torres-Torres J5 papers · 2026
Department of Reproductive and Perinatal Health Research, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico.
Papers in Europe PMC - 05Limesand SW4 papers · 2026
School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona 85719, USA.
Papers in Europe PMC - 06Macgowan CK4 papers · 2026
Translational Medicine, Hospital for Sick Children, Toronto, Canada.
Papers in Europe PMC - 07Martinez-Portilla R4 papers · 2025
Clinical Research Branch, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico.
Papers in Europe PMC - 08Monroy-Muñoz IE4 papers · 2026
Department of Reproductive and Perinatal Health Research, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico.
Papers in Europe PMC - 09Solis-Paredes JM4 papers · 2026
Department of Reproductive and Perinatal Health Research, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico.
Papers in Europe PMC - 10Anderson MJ3 papers · 2026
School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona 85719, USA.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
8
interventional trials for this specific condition
8 interventional trials matched this specific condition name; 2 currently recruiting in our sample.
Data as of 27 July 2026
8 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 90.6th percentile).
high confidence · 90.6th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
8 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT06861309·RECRUITING·Placental Imaging Techniques
Conditions: Fetal Growth Restriction (FGR) · Placental Insufficiency · Preeclampsia · Still Births·Matched via name + MeSH
- NCT07098975·RECRUITING·Statin Intervention for Severe Early-Onset Placental Insufficiency. (STATIN-PRE Trial)
Conditions: Preeclampsia (PE) · Intrauterine Growth Restriction (IUGR) · Placental Insufficiency·Matched via name + MeSH
Observational and natural-history studies
16 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT07072052·NOT YET RECRUITING·Oxford Luteal Dysfunction and Placental Insufficiency Study
Conditions: Pre-eclampsia·Matched via name + MeSH
- NCT07144839·RECRUITING·Placental Risk Assessment to CusTomize Individualized Pregnancy Care and Evaluation
Conditions: Stillbirth · Placental Insufficiency·Matched via name + MeSH
- NCT05423665·RECRUITING·Speckle Tracking Echocardiography as a Tool for Early Diagnosis of Impaired Fetal Growth Twin Pregnancies
Conditions: Fetal Growth Restriction · Cardiac Remodeling, Ventricular · Placental Insufficiency · Air Pollution·Matched via name + MeSH
- NCT06339606·NOT YET RECRUITING·Pregnancy Repository
Conditions: Pregnancy Related · Fetal Growth Retardation · Placental Insufficiency · Preeclampsia·Matched via name + MeSH
- NCT07676708·NOT YET RECRUITING·Patterns of Aortic Isthmus Doppler in Early Fetal Growth Restriction , and the Changes in Aortic Isthmus Doppler Parameters With Every Changes of Other Early Iugr Parameters Like EFW, Uterine Artery Doppler, Cerebroplacental Ratio and Ductus Venosus Doppler in Comparison With Normal Group .
Conditions: Fetal Growth Restriction · Placental Insufficiency · Aortic Isthmus Doppler · Cerebroplacental Ratio·Matched via name + MeSH
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Placental insufficiency" OR "Uteroplacental vascular insufficiency"
MeSH descriptor terms unioned into the query: Placental Insufficiency
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Placental insufficiency" OR "Uteroplacental vascular insufficiency"
Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 8 interventional · 16 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T16:15:22.305Z