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ORPHA:439167

Placental insufficiency

high confidenceDisorder

Also known as: Uteroplacental vascular insufficiency

Publications

12,359

96.2th percentile

Trials

8

Interventional, condition-specific

Researchers

1,157

Distinct authors in sample

Gene link

—

Readiness

5/6

Stages with a signal

Clinical definition (Orphanet)

A rare obstetric disease characterized by inadequate blood flow to the placenta during pregnancy, resulting in a decrease in trans-placental transfer of oxygen and nutrients to the fetus, potentially leading to fetal growth retardation, distress, or death. Maternal risk factors include preeclampsia, gestational diabetes, and smoking, among others.

How rare: 1-5 / 10 000 — about one to five people per ten thousand (still uncommon, but less ultra-rare).

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (1)

uteroplacental vascular insufficiency

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

5/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    12,359 matched papers (7,439 in last 10 years) Source

  3. Phenotype characterisedPresent

    16 HPO annotations (e.g. Proportionate short stature; Systemic lupus erythematosus; Antiphospholipid antibody positivity) Source

  4. Animal modelPresent

    1 genotype model (Mus musculus) Source

  5. Orphan designationPartial

    1 EMA designation (none yet with FDA orphan-indication approval) — e.g. adenoviral vector serotype 5 containing the vascular endothelial growth factor D isoform (preprocessed short form) from a CMV promoter Source

  6. Interventional trialPresent

    8 matched on ClinicalTrials.gov (2 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

16

Associated phenotypes · MONDO:0005919

  • Proportionate short stature
  • Systemic lupus erythematosus
  • Antiphospholipid antibody positivity
  • Neurodevelopmental abnormality
  • Insulin resistance

Showing 5 of 16 — open Monarch for the full list.

Animal models (Monarch / Alliance)

1

Model associations linked to this Mondo ID

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

1

Designation · no FDA orphan-indication approval yet

  • EMA adenoviral vector serotype 5 containing the vascular endothelial growth factor D isoform (preprocessed short form) from a CMV promoterTreatment of placental insufficiency · 15/01/2015 · PositiveEMA designation

Sources: FDA OOPD · EMA orphan designations

Open Targets candidates

2

Drugs / clinical candidates · MONDO_0005919

CTD chemicals (MyDisease.info)

3 associated chemicals. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • bisphenol A · marker/mechanism
  • Dronabinol · marker/mechanism
  • sodium arsenite · marker/mechanism

MyDisease.info · MONDO:0005919

Literature

Is anyone studying this?

12,359

12,359 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

12,359 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

7,439 in the last 10 years · high confidence · 96.2th percentile (publications denominator)

Phrase hits: 12,359 · MeSH hits: 388

Open Europe PMC search

Who's working on it?

1,157

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Brown LD6 papers · 2026

    Department of Pediatrics, Section of Neonatology, Perinatal Research Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.

    Papers in Europe PMC
  2. 02
    Espino-Y-Sosa S5 papers · 2026

    Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City, Mexico.

    Papers in Europe PMC
  3. 03
    Rojas-Zepeda L5 papers · 2026

    Maternal-Fetal Department, Instituto Materno Infantil del Estado de Mexico, Toluca, Mexico.

    Papers in Europe PMC
  4. 04
    Torres-Torres J5 papers · 2026

    Department of Reproductive and Perinatal Health Research, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico.

    Papers in Europe PMC
  5. 05
    Limesand SW4 papers · 2026

    School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona 85719, USA.

    Papers in Europe PMC
  6. 06
    Macgowan CK4 papers · 2026

    Translational Medicine, Hospital for Sick Children, Toronto, Canada.

    Papers in Europe PMC
  7. 07
    Martinez-Portilla R4 papers · 2025

    Clinical Research Branch, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico.

    Papers in Europe PMC
  8. 08
    Monroy-Muñoz IE4 papers · 2026

    Department of Reproductive and Perinatal Health Research, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico.

    Papers in Europe PMC
  9. 09
    Solis-Paredes JM4 papers · 2026

    Department of Reproductive and Perinatal Health Research, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico.

    Papers in Europe PMC
  10. 10
    Anderson MJ3 papers · 2026

    School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona 85719, USA.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

8

interventional trials for this specific condition

8 interventional trials matched this specific condition name; 2 currently recruiting in our sample.

Data as of 11 September 2026

8 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 91.5th percentile).

high confidence · 91.5th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

8 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

16 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 20 · after dedupe 19 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 19 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (19)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Placental insufficiency — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Placental insufficiency" OR "Uteroplacental vascular insufficiency"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Placental Insufficiency

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Placental insufficiency" OR "Uteroplacental vascular insufficiency"

Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 8 interventional · 16 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T16:15:22.305Z