ORPHA:435988
Chronic atrial and intestinal dysrhythmia syndrome
Also known as: CAID syndrome · Chronic atrial dysrhythmia-intestinal motility disorder
Query health: suspect — Only one of 2 strategies returned hits (phrase).
Publications
284
81.8th percentile
Trials
0
Interventional, condition-specific
Researchers
1,397
Distinct authors in sample
Gene link
SGO1
Moderate
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A rare genetic disease characterized by co-occurrence of sick sinus syndrome (manifesting as sinus bradycardia, often requiring pacemaker implantation) and chronic intestinal pseudo-obstruction (which may be of myogenic or neurogenic origin and usually requires total parenteral nutrition), with an age of onset within the first four decades of life. Other cardiac features, such as atrial flutter or fibrillation and valve anomalies, may also be present.
How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0014528
- OMIM:616201
- UMLS:C4015474
Additional Mondo synonyms (3)
caid syndrome · chronic atrial and intestinal dysrhythmia · chronic atrial dysrhythmia-intestinal motility disorder
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No matched interventional trial; the gene is known and literature exists — preclinical or natural-history work may still be the practical next step.
- Gene identifiedPresent
Moderate — SGO1
- LiteraturePresent
284 matched papers (247 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Probably — there is moderate evidence for SGO1.
GenCC classification: Moderate.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
284
284 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
284 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
247 in the last 10 years · medium confidence · 81.8th percentile (publications denominator)
Phrase hits: 284 · MeSH hits: 0
Who's working on it?
1,397
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Shawcross DL7 papers · 2025
Institute of Liver Studies, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK
Papers in Europe PMC - 02Wang Z7 papers · 2026
Department of Cancer Biology, The Beckman Research Institute of City of Hope, Duarte, CA, USA.
Papers in Europe PMC - 03Maasoumy B6 papers · 2026
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Papers in Europe PMC - 04Andelfinger G5 papers · 2021
Centre Hospitalier Universitaire Sainte-Justine Research Centre, Pediatrics Department, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Papers in Europe PMC - 05Cornberg M5 papers · 2026
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Papers in Europe PMC - 06Drácz B4 papers · 2023
Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, 1083 Budapest, Hungary.
Papers in Europe PMC - 07Hagymási K4 papers · 2023
Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, 1083 Budapest, Hungary.
Papers in Europe PMC - 08Kraft ARM4 papers · 2026
Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
Papers in Europe PMC - 09Li Y4 papers · 2026
Institute of Human Genetics, University Medical Center Göttingen, Göttingen, Germany.
Papers in Europe PMC - 10Miheller P4 papers · 2023
Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, 1083 Budapest, Hungary.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
medium confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Chronic atrial and intestinal dysrhythmia syndrome" OR "CAID syndrome" OR "Chronic atrial dysrhythmia-intestinal motility disorder" OR "chronic atrial and intestinal dysrhythmia"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Chronic atrial and intestinal dysrhythmia syndrome" OR "CAID syndrome" OR "Chronic atrial dysrhythmia-intestinal motility disorder" OR "chronic atrial and intestinal dysrhythmia" OR "SGO1"
Recall-expansion terms: SGO1
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: suspect — strategies attempted: phrase, recall-expansion; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (284) is high for prevalence class "<1 / 1 000 000" — confidence capped at medium
Ingested 2026-07-27T16:06:21.506Z