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ORPHA:423786

Undifferentiated carcinoma of stomach

high confidenceDisorder

Also known as: Undifferentiated gastric carcinoma

Publications

495

79.2th percentile

Trials

2

Interventional, condition-specific

Researchers

1,225

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

Undifferentiated carcinoma of stomach is a rare epithelial tumour of the stomach that lacks any features of differentiation beyond an epithelial . The presenting symptoms are usually vague and nonspecific, such as weight loss, anorexia, fatigue, epigastric pain and discomfort, heartburn and nausea, vomiting or hematemesis. Patients may also be asymptomatic. Ascites, jaundice, intestinal obstruction and peripheral lymphadenopathy indicate advanced stages and metastatic spread.

How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (9)

Gastric undifferentiated carcinoma · anaplastic carcinoma of stomach · anaplastic carcinoma of the stomach · anaplastic gastric carcinoma · stomach undifferentiated carcinoma · undifferentiated carcinoma of stomach · undifferentiated carcinoma of the stomach · undifferentiated gastric (stomach) cancer · undifferentiated gastric carcinoma

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    495 matched papers (206 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    2 matched on ClinicalTrials.gov

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

495

495 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

495 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

206 in the last 10 years · high confidence · 79.2th percentile (publications denominator)

Phrase hits: 495 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,225

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Luo B6 papers · 2023

    Department of Pathogenic Biology, School of Basic Medicine, Qingdao University, Qingdao, China.

    Papers in Europe PMC
  2. 02
    Zhang Y6 papers · 2026

    Department of Pathogenic Biology, School of Basic Medicine, Qingdao University, Qingdao, China.

    Papers in Europe PMC
  3. 03
    Chen X5 papers · 2025

    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.

    Papers in Europe PMC
  4. 04
    Li Q5 papers · 2025

    Department of Integrated Traditional Chinese and Western Medicine, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.

    Papers in Europe PMC
  5. 05
    Chen L4 papers · 2025

    Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China.

    Papers in Europe PMC
  6. 06
    Chen Y4 papers · 2026

    Digestive Medical Department, Minqin People's Hospital, Minqin.

    Papers in Europe PMC
  7. 07
    Chen Z4 papers · 2026

    Department of General Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315000, People's Republic of China.

    Papers in Europe PMC
  8. 08
    Li L4 papers · 2026

    Pathology Department, Qilu Hospital of Shandong University, Jinan, China.

    Papers in Europe PMC
  9. 09
    Li T4 papers · 2024

    Cancer Immunotherapy Program, University of California, San Francisco, California.

    Papers in Europe PMC
  10. 10
    Liu S4 papers · 2026

    Department of Medical Microbiology, Qingdao University Medical College, Qingdao, 266021, China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

2

interventional trials for this specific condition

2 interventional trials matched this specific condition name; none in our sample are currently recruiting. 51 trials are registered for undifferentiated carcinoma, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

2 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 82.4th percentile).

high confidence · 82.4th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

2 interventional trials matched after quoted-phrase search and title/condition post-filter.

No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.

Broader category: undifferentiated carcinoma

51

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Undifferentiated carcinoma of stomach" OR "Undifferentiated carcinoma of the stomach" OR "Undifferentiated gastric carcinoma" OR "Gastric undifferentiated carcinoma" OR "anaplastic carcinoma of stomach" OR "anaplastic carcinoma of the stomach" OR "anaplastic gastric carcinoma" OR "stomach undifferentiated carcinoma" OR "undifferentiated gastric (stomach) cancer"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Undifferentiated carcinoma of stomach" OR "Undifferentiated carcinoma of the stomach" OR "Undifferentiated gastric carcinoma" OR "Gastric undifferentiated carcinoma" OR "anaplastic carcinoma of stomach" OR "anaplastic carcinoma of the stomach" OR "anaplastic gastric carcinoma" OR "stomach undifferentiated carcinoma" OR "undifferentiated gastric (stomach) cancer"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 2 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"undifferentiated carcinoma"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T15:53:21.926Z