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ORPHA:399329

Epiphysiolysis of the hip

low confidenceDisorder

Also known as: Slipped upper femoral epiphysis · Epiphysiolysis of the upper femur · Femoral head epiphysiolysis · SCFE · SUFE · Slipped capital femoral epiphysis

Publications

4,072

Trials

15

Interventional, condition-specific

Researchers

927

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

Epiphysiolysis of the hip is a rare osteonecrosis disorder characterized by unilateral or bilateral disruption of the capital femoral physis with varying degrees of posterior epiphysis translation and simultaneous anterior metaphysis displacement. Patients typically present in pre-adolescence/adolescence with pain of variable intensity in varying locations (hip, groin, thigh, knee).

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (7)

SufE · epiphysiolysis capitis femoris · epiphysiolysis of the upper femur · femoral head epiphysiolysis · slipped capital femoral epiphysis · slipped femoral capital epiphyses · slipped upper femoral epiphysis

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    4,072 matched papers (1,938 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    15 matched on ClinicalTrials.gov

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

4,072

4,072 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

4,072 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

1,938 in the last 10 years · low confidence

Phrase hits: 4,070 · MeSH hits: 10

Open Europe PMC search

Who's working on it?

927

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Hosseinzadeh P7 papers · 2026

    Department of Orthopaedics, Washington University School of Medicine, St. Louis, Missouri.

    Papers in Europe PMC
  2. 02
    Novais EN7 papers · 2026

    Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA.

    Papers in Europe PMC
  3. 03
    Momtaz D6 papers · 2025

    Department of Orthopaedics, UT Health San Antonio, San Antonio, Texas.

    Papers in Europe PMC
  4. 04
    Gonuguntla R5 papers · 2025

    Department of Orthopaedics, UT Health San Antonio, San Antonio, Texas.

    Papers in Europe PMC
  5. 05
    Kiapour AM5 papers · 2025

    Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA. Ata.Kiapour@childrens.harvard.edu.

    Papers in Europe PMC
  6. 06
    Sankar WN5 papers · 2026

    Children's Hospital of Philadelphia, Orthopedic Center, Philadelphia, PA, USA.

    Papers in Europe PMC
  7. 07
    Torres-Izquierdo B4 papers · 2025

    Department of Orthopaedics, Washington University School of Medicine, St. Louis, MO.

    Papers in Europe PMC
  8. 08
    De Silva S3 papers · 2026

    Department of Orthopedic Surgery and Sports Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

    Papers in Europe PMC
  9. 09
    Hosseinzadeh S3 papers · 2025

    Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA.

    Papers in Europe PMC
  10. 10
    Singh A3 papers · 2024

    From the UT Health San Antonio (Mr. Singh, Mr. Kotzur, Mr. Momtaz, Mr. Gonuguntla, and Dr. Seifi), Department of Orthopaedics, San Antonio, TX; the Washington University School of Medicine (Dr. Torres-Izquierdo, Dr. Hoveidaei, and Dr. Hosseinzadeh), Department of Orthopaedics, St. Louis, MO; and the Hospital Niño Jesus (Dr. Galán-Olleros), Department of Orthopaedics, Madrid, Spain.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

15

interventional trials for this specific condition

15 interventional trials matched this specific condition name; none in our sample are currently recruiting.

Data as of 27 July 2026

15 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 93.5th percentile).

low confidence · 93.5th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

15 interventional trials matched after quoted-phrase search and title/condition post-filter.

No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.

Observational and natural-history studies

5 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Epiphysiolysis of the hip" OR "Epiphysiolysis of hip" OR "Slipped upper femoral epiphysis" OR "Epiphysiolysis of the upper femur" OR "Epiphysiolysis of upper femur" OR "Femoral head epiphysiolysis" OR "Slipped capital femoral epiphysis" OR "epiphysiolysis capitis femoris" OR "slipped femoral capital epiphyses"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Slipped Capital Femoral Epiphyses

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Epiphysiolysis of the hip" OR "Epiphysiolysis of hip" OR "Slipped upper femoral epiphysis" OR "Epiphysiolysis of the upper femur" OR "Epiphysiolysis of upper femur" OR "Femoral head epiphysiolysis" OR "Slipped capital femoral epiphysis" OR "epiphysiolysis capitis femoris" OR "slipped femoral capital epiphyses" OR "Slipped Capital Femoral Epiphyses"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 15 interventional · 5 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: SCFE; SUFE

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 2 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (4072) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T15:23:54.601Z