ORPHA:399307
Idiopathic avascular necrosis
Also known as: Idiopathic AVN
Publications
654
86.3th percentile
Trials
0
Interventional, condition-specific
Researchers
982
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A rare osteonecrosis characterized by bone necrosis due to disrupted blood supply in the absence of a known cause. Affected bones include the femoral head, talus, vertebral body, humerus, and scaphoid, among others. Patients may initially be asymptomatic but subsequently present with gradually developing refractory pain, swelling, and reduced range of motion. If left untreated, the condition may progress to bone collapse with secondary degeneration, fragmentation, and pathological fracture, as well as osteoarthritis.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0018380
- UMLS:C1404767
Additional Mondo synonyms (1)
idiopathic AVN
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
654 matched papers (340 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPartial
None under the specific name; 118 for broader category avascular necrosis
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
654
654 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
654 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
340 in the last 10 years · high confidence · 86.3th percentile (publications denominator)
Phrase hits: 654 · MeSH hits: 0
Who's working on it?
982
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Andriollo L4 papers · 2025
Sezione di Chirurgia Protesica ad Indirizzo Robotico, Unità di Traumatologia Dello Sport, UOC Ortopedia e Traumatologia, Brescia, Italy.
Papers in Europe PMC - 02Benazzo F4 papers · 2025
Sezione di Chirurgia Protesica ad Indirizzo Robotico, Unità di Traumatologia Dello Sport, UOC Ortopedia e Traumatologia, Brescia, Italy.
Papers in Europe PMC - 03Liao S4 papers · 2026
Department of Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Papers in Europe PMC - 04Rossi SMP4 papers · 2025
Sezione di Chirurgia Protesica ad Indirizzo Robotico, Unità di Traumatologia Dello Sport, UOC Ortopedia e Traumatologia, Brescia, Italy.
Papers in Europe PMC - 05Sangaletti R4 papers · 2025
Sezione di Chirurgia Protesica ad Indirizzo Robotico, Unità di Traumatologia Dello Sport, UOC Ortopedia e Traumatologia, Brescia, Italy.
Papers in Europe PMC - 06Ding X3 papers · 2025
Department of Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Papers in Europe PMC - 07Hu J3 papers · 2026
Department of Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Papers in Europe PMC - 08Jayakumar T3 papers · 2025
Orthopaedics, Sunshine Bone and Joint Institute, KIMS-Sunshine Hospitals, Hyderabad, IND.
Papers in Europe PMC - 09Moran SL3 papers · 2026
Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.
Papers in Europe PMC - 10Takai S3 papers · 2020Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name. 1 observational study did — shown below because natural-history and cohort work can be an important step toward a trial. 118 trials are registered for avascular necrosis, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
118 interventional trials matched avascular necrosis, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: avascular necrosis
118
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT05357378·RECRUITING·Safety and Effectiveness of the HIT Reverse HRS
Conditions: Degenerative Joint Disease · Osteoarthritis, Hip · Avascular Necrosis of Hip · Traumatic Arthropathy-Hip·Matched via name phrase
- NCT06388993·RECRUITING·Marrow Cellution™ vs. Traditional BMA Harvest Project
Conditions: Hip Arthropathy · Avascular Necrosis of Bone · Subchondral Cysts·Matched via name phrase
- NCT07240649·NOT YET RECRUITING·Emerging Indications for Hyperbaric Oxygen Treatment
Conditions: Post-COVID-19 Condition · Ulcerative Colitis · Crohn Disease · Calciphylaxis·Matched via name phrase
- NCT07104084·RECRUITING·Influence of Antiseptic Washes on Wound Healing Complications After THA
Conditions: Hip Osteoarthritis · Avascular Necrosis of Femur Head·Matched via name phrase
- NCT06016634·RECRUITING·Alendronate for Osteonecrosis in Adults With Sickle Cell Disease
Conditions: Sickle Cell Disease · Sickle Cell Anemia · Osteonecrosis · Ischemic Necrosis·Matched via name phrase
- NCT06631638·RECRUITING·EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))
Conditions: Osteoarthritis · Traumatic Arthritis · Rheumatoid Arthritis · Congential Hip Dysplasia·Matched via name phrase
- NCT06772558·NOT YET RECRUITING·Desflurane Potentially Induces Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Perioperative Procedures by Modulating Cdc42 and Clock Proteins
Conditions: Avascular Necrosis of the Femoral Head · Coronary Artery Disease (CAD) · Benign Prostatic Hyperplasia (BPH) · Cholecystitis·Matched via name phrase
- NCT03048201·RECRUITING·Physica System Total Knee Replacement Registry Study
Conditions: Osteoarthritis, Knee · Traumatic Arthritis · Avascular Necrosis · Degenerative Joint Disease of Knee·Matched via name phrase
- NCT07255768·ENROLLING BY INVITATION·Comparison of the Efficacy of Pericapsular Nerve Group Block Alone Versus Pericapsular Nerve Group Block Combined With Superior Cluneal and Superior Gluteal Nerve Blocks in Patients Undergoing Hip Surgery
Conditions: Hip Osteoarthritis · Osteonecrosis of the Femoral Head · Avascular Necrosis of Femur Head · Dysplasia of Hip Joint·Matched via name phrase
- NCT07101562·RECRUITING·Clinical Transformation of Bone Reconstruction With Autologous Bone Marrow Mesenchymal Stem Cells in Vitro to Repair Avascular Necrosis of Femur Head
Conditions: Avascular Necrosis of Femur Head·Matched via name phrase
- NCT05548972·ENROLLING BY INVITATION·G7 Dual Mobility With Vivacit-E or Longevity PMCF
Conditions: Hip Osteoarthritis · Rheumatoid Arthritis · Joint Diseases · Avascular Necrosis·Matched via name phrase
- NCT06931301·NOT YET RECRUITING·Effect of HBOT on Femoral Head Avascular Necrosis (AVN)
Conditions: Osteonecrosis · Avascular Necrosis·Matched via name phrase
- NCT05679232·RECRUITING·Hydrogel Coating to Reduce Post-surgical Infection After Joint Arthroplasty
Conditions: Arthritis · Traumatic Arthritis · Avascular Necrosis·Matched via name phrase
- NCT05587244·ENROLLING BY INVITATION·G7 Freedom Constrained Vivacit-E Liners
Conditions: Osteoarthritis, Hip · Rheumatoid Arthritis · Non-Union Fracture · Trochanteric Fractures·Matched via name phrase
- NCT06123481·RECRUITING·Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis
Conditions: Osteonecrosis of the Femoral Head · Avascular Necrosis of the Femoral Head·Matched via name phrase
Observational and natural-history studies
1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT01440218·ENROLLING BY INVITATION·Idiopathic Diseases of Man
Conditions: Rare Disease · Idiopathic Disease·Matched via recall expansion
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Idiopathic avascular necrosis" OR "Idiopathic AVN"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Idiopathic avascular necrosis" OR "Idiopathic AVN" OR "primary avascular necrosis" OR "idiopathic disease"
Recall-expansion terms: primary avascular necrosis, idiopathic disease
Study-type breakdown: 0 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"avascular necrosis"
Query health: ok — strategies attempted: phrase, recall-expansion; with hits: phrase, recall-expansion
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T15:23:41.191Z