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ORPHA:398109

Neonatal autoimmune hemolytic anemia

high confidenceDisorder

Also known as: Neonatal AHA · Neonatal AIHA

Publications

8

23.5th percentile

Trials

0

Interventional, condition-specific

Researchers

50

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare, secondary, autoimmune disease characterized by onset of hemolytic anemia in the period associated with a positive direct antiglobulin test. may be associated.

How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (2)

neonatal AHA · neonatal AIHA

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    8 matched papers (7 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPartial

    None under the specific name; 72 for broader category autoimmune hemolytic anemia

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

8

8 papers have ever been indexed under this name. For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

8 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

7 in the last 10 years · high confidence · 23.5th percentile (publications denominator)

Phrase hits: 8 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

50

Distinct author names in 8 sampled papers — named people below.

Who's working on it?

No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.

  1. 01
    Alsaleem M1 paper · 2020

    Pediatrics Department, Neonatology, Children's Mercy Hospital, Kansas City, MO 64108, USA.

    Papers in Europe PMC
  2. 02
    Aydin F1 paper · 2021

    Department of Pediatrics, Division of Pediatric Hematology and Oncology & Pediatric HSCT Unit.

    Papers in Europe PMC
  3. 03
    Barcellini W1 paper · 2023

    Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

    Papers in Europe PMC
  4. 04
    Black LV1 paper · 2009

    Division of Pediatric Hemato-Oncology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.

    Papers in Europe PMC
  5. 05
    Bortolotti M1 paper · 2023

    Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

    Papers in Europe PMC
  6. 06
    Broides A1 paper · 2021

    Soroka University Medical Center, Beer Sheva, Israel.

    Papers in Europe PMC
  7. 07
    Cansever M1 paper · 2021

    Pediatrics, Division of Pediatric Immunology, Faculty of Medicine.

    Papers in Europe PMC
  8. 08
    Chen F1 paper · 2023

    Clinical Hematology, Barts Health National Health Service Trust, Queen Mary University, London, United Kingdom.

    Papers in Europe PMC
  9. 09
    Couto M1 paper · 2026

    Haematology, Mater Misericordiae University Hospital, Dublin, IRL.

    Papers in Europe PMC
  10. 10
    Eken A1 paper · 2021

    Departments of Medical Biology.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

0

interventional trials for this specific condition

No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present). 72 trials are registered for autoimmune hemolytic anemia, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.

high confidence · 36.5th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.

72 interventional trials matched autoimmune hemolytic anemia, the broader category — listed below. Those studies are not counted in the condition-specific total.

Broader category: autoimmune hemolytic anemia

72

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Neonatal autoimmune hemolytic anemia" OR "Neonatal AHA" OR "Neonatal AIHA"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Neonatal autoimmune hemolytic anemia" OR "Neonatal AHA" OR "Neonatal AIHA"

Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"autoimmune hemolytic anemia"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T15:19:56.004Z