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ORPHA:391497

Juvenile myasthenia gravis

high confidenceSubtype of disorder

Also known as: Childhood myasthenia gravis · Juvenile acquired myasthenia · Juvenile autoimmune myasthenia gravis

Publications

347

72.9th percentile

Trials

1

Interventional, condition-specific

Researchers

921

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

Juvenile myasthenia gravis (MG) is a rare form of MG, an autoimmune disorder of the neuromuscular junction resulting in ocular manifestations or generalized weakness, with onset before 18 years of age.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (6)

childhood myasthenia gravis · juvenile acquired myasthenia · juvenile autoimmune myasthenia gravis · myasthenia gravis of childhood · paediatric myasthenia gravis · pediatric myasthenia gravis

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    347 matched papers (143 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    1 matched on ClinicalTrials.gov (1 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

347

347 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

347 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

143 in the last 10 years · high confidence · 72.9th percentile (publications denominator)

Phrase hits: 347 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

921

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Kang PB7 papers · 2023

    Division of Pediatric Neurology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA.

    Papers in Europe PMC
  2. 02
    Li Y6 papers · 2026

    Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, China.

    Papers in Europe PMC
  3. 03
    Palace J5 papers · 2022

    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

    Papers in Europe PMC
  4. 04
    Ramdas S5 papers · 2025

    Department of Paediatric Neurology, John Radcliffe Hospital, Oxford, United Kingdom.

    Papers in Europe PMC
  5. 05
    Zhang Y5 papers · 2026

    Department of Traditional Chinese Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.

    Papers in Europe PMC
  6. 06
    Chen J4 papers · 2025

    Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, No. 20, Section 3, Ren Min Nan Lu, Chengdu, 610041 Sichuan China.

    Papers in Europe PMC
  7. 07
    Darras BT4 papers · 2014
    Papers in Europe PMC
  8. 08
    Della Marina A4 papers · 2022

    Department of Neuropediatrics, Developmental Neurology and Social Pediatrics, University of Essen, Essen, Germany.

    Papers in Europe PMC
  9. 09
    Feng H4 papers · 2018

    Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

    Papers in Europe PMC
  10. 10
    Heckmann JM4 papers · 2022

    Division of Neurology, Department of Medicine, Groote Schuur Hospital. jeanine.heckmann@uct.ac.za

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

1

interventional trials for this specific condition

1 interventional trial matched this specific condition name; 1 currently recruiting in our sample. 223 trials are registered for myasthenia gravis, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

1 interventional trial — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 76.8th percentile).

high confidence · 76.8th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

1 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: myasthenia gravis

223

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

General rare disease registries you may be eligible for

These studies enroll across many rare conditions. They are not counted as evidence that anyone is studying this specific disease.

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Juvenile myasthenia gravis" OR "Childhood myasthenia gravis" OR "Juvenile acquired myasthenia" OR "Juvenile autoimmune myasthenia gravis" OR "myasthenia gravis of childhood" OR "myasthenia gravis of the childhood" OR "paediatric myasthenia gravis" OR "pediatric myasthenia gravis"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Juvenile myasthenia gravis" OR "Childhood myasthenia gravis" OR "Juvenile acquired myasthenia" OR "Juvenile autoimmune myasthenia gravis" OR "myasthenia gravis of childhood" OR "myasthenia gravis of the childhood" OR "paediatric myasthenia gravis" OR "pediatric myasthenia gravis"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 1 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"myasthenia gravis"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T15:08:04.782Z