RARE DISEASERESEARCH ATLAS
Open navigation menu

ORPHA:363494

Non-seminomatous germ cell tumor of testis

high confidenceDisorder

Also known as: Non-dysgerminomatous germ cell tumor of testis · Testicular non seminomatous germ cell tumor · Testicular non-dysgerminomatous germ cell tumor

Publications

81

42th percentile

Trials

3

Interventional, condition-specific

Researchers

430

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A form of testicular germ cell tumor occurring in the third decade of life with a usually painless unilateral mass in the scrotum or, in some cases, with gynaecomastia and/or back and flack pain. The clinical course is more aggressive than testicular seminomatous germ cell tumors with rapid involvement of blood vessels and a poorer prognosis. Histologically, the tumour can be either undifferentiated (embryonal carcinoma), differentiated (teratoma, yolk sac tumor, choriocarcinoma), or can consist of a mixture of seminomatous and nonseminomatous components.

How rare: 1-9 / 100 000 — about one to nine people per hundred thousand.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (11)

non-dysgerminomatous germ cell tumor of testis · non-dysgerminomatous germ cell tumour of testis · non-seminomatous germ cell tumor of testis · non-seminomatous germ cell tumour of testis · testicular germ cell tumor non-seminomatous · testicular germ cell tumour non-seminomatous · testicular non seminomatous germ cell tumor · testicular non seminomatous germ cell tumour · testicular non-dysgerminomatous germ cell tumor · testicular non-dysgerminomatous germ cell tumour · testicular non-seminomatous germ cell tumor

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    81 matched papers (32 in last 10 years) Source

  3. Phenotype characterisedNot found

    No HPO disease–phenotype associations via Monarch for these Mondo IDs

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    3 matched on ClinicalTrials.gov (1 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

None returned for this Mondo ID. That often means “not linked under this ID,” not “no clinical features.”

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

6

Drugs / clinical candidates · MONDO_0006447

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

81

81 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

81 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

32 in the last 10 years · high confidence · 42th percentile (publications denominator)

Phrase hits: 81 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

430

Distinct author names in 81 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Batra A2 papers · 2024

    Department of Medical Oncology, Dr B.R.A.I.R.C.H, All India Institute of Medical Sciences, New Delhi, India. batraatul85@gmail.com.

    Papers in Europe PMC
  2. 02
    Habuchi T2 papers · 2015

    Department of Urology, Akita University, Akita, Japan.

    Papers in Europe PMC
  3. 03
    Kaushal S2 papers · 2024

    Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

    Papers in Europe PMC
  4. 04
    Kumar S2 papers · 2024

    Department of Medical Oncology, Dr B.R.A.I.R.C.H, All India Institute of Medical Sciences, New Delhi, India.

    Papers in Europe PMC
  5. 05
    Paterson RF2 papers · 1998

    Department of Surgery, Division of Urology, University of British Columbia, Vancouver, BC.

    Papers in Europe PMC
  6. 06
    Pathak N2 papers · 2024

    Department of Medical Oncology, Dr B.R.A.I.R.C.H, All India Institute of Medical Sciences, New Delhi, India.

    Papers in Europe PMC
  7. 07
    Raj A2 papers · 2024

    Department of Medical Oncology, Dr B.R.A.I.R.C.H, All India Institute of Medical Sciences, New Delhi, India.

    Papers in Europe PMC
  8. 08
    Ray M2 papers · 2024

    Department of Surgical Oncology, Dr B.R.A.I.R.C.H, All India Institute of Medical Sciences, New Delhi, India.

    Papers in Europe PMC
  9. 09
    Seth A2 papers · 2024

    Department of Urology, All India Institute of Medical Sciences, New Delhi, India.

    Papers in Europe PMC
  10. 10
    Singh P2 papers · 2024

    Department of Urology, All India Institute of Medical Sciences, New Delhi, India.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

3

interventional trials for this specific condition

3 interventional trials matched this specific condition name; 1 currently recruiting in our sample.

Data as of 11 September 2026

3 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 86.7th percentile).

high confidence · 86.7th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

3 interventional trials matched after quoted-phrase search and title/condition post-filter.

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 0 · after dedupe 0 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 0 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Non-seminomatous germ cell tumor of testis — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Non-seminomatous germ cell tumor of testis" OR "Non-seminomatous germ cell tumor of the testis" OR "Non-dysgerminomatous germ cell tumor of testis" OR "Non-dysgerminomatous germ cell tumor of the testis" OR "Testicular non seminomatous germ cell tumor" OR "Testicular non-dysgerminomatous germ cell tumor" OR "non-dysgerminomatous germ cell tumour of testis" OR "non-dysgerminomatous germ cell tumour of the testis" OR "non-seminomatous germ cell tumour of testis" OR "non-seminomatous germ cell tumour of the testis" OR "testicular germ cell tumor non-seminomatous" OR "testicular germ cell tumour non-seminomatous" OR "testicular non seminomatous germ cell tumour" OR "testicular non-dysgerminomatous germ cell tumour" OR "testicular non-seminomatous germ cell tumor"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Non-seminomatous germ cell tumor of testis" OR "Non-seminomatous germ cell tumor of the testis" OR "Non-dysgerminomatous germ cell tumor of testis" OR "Non-dysgerminomatous germ cell tumor of the testis" OR "Testicular non seminomatous germ cell tumor" OR "Testicular non-dysgerminomatous germ cell tumor" OR "non-dysgerminomatous germ cell tumour of testis" OR "non-dysgerminomatous germ cell tumour of the testis" OR "non-seminomatous germ cell tumour of testis" OR "non-seminomatous germ cell tumour of the testis" OR "testicular germ cell tumor non-seminomatous" OR "testicular germ cell tumour non-seminomatous" OR "testicular non seminomatous germ cell tumour" OR "testicular non-dysgerminomatous germ cell tumour" OR "testicular non-seminomatous germ cell tumor"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 3 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T14:36:47.174Z