ORPHA:363494
Non-seminomatous germ cell tumor of testis
Also known as: Non-dysgerminomatous germ cell tumor of testis · Testicular non seminomatous germ cell tumor · Testicular non-dysgerminomatous germ cell tumor
Publications
81
45.2th percentile
Trials
3
Interventional, condition-specific
Researchers
430
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A form of testicular germ cell tumor occurring in the third decade of life with a usually painless unilateral mass in the scrotum or, in some cases, with gynaecomastia and/or back and flack pain. The clinical course is more aggressive than testicular seminomatous germ cell tumors with rapid involvement of blood vessels and a poorer prognosis. Histologically, the tumour can be either undifferentiated (embryonal carcinoma), differentiated (teratoma, yolk sac tumor, choriocarcinoma), or can consist of a mixture of seminomatous and nonseminomatous components.
How rare: 1-9 / 100 000 — about one to nine people per hundred thousand.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0006447
- UMLS:C2057625
- NCIT:C9313
Additional Mondo synonyms (11)
non-dysgerminomatous germ cell tumor of testis · non-dysgerminomatous germ cell tumour of testis · non-seminomatous germ cell tumor of testis · non-seminomatous germ cell tumour of testis · testicular germ cell tumor non-seminomatous · testicular germ cell tumour non-seminomatous · testicular non seminomatous germ cell tumor · testicular non seminomatous germ cell tumour · testicular non-dysgerminomatous germ cell tumor · testicular non-dysgerminomatous germ cell tumour · testicular non-seminomatous germ cell tumor
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
81 matched papers (32 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
3 matched on ClinicalTrials.gov (1 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
81
81 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
81 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
32 in the last 10 years · high confidence · 45.2th percentile (publications denominator)
Phrase hits: 81 · MeSH hits: 0
Who's working on it?
430
Distinct author names in 81 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Batra A2 papers · 2024
Department of Medical Oncology, Dr B.R.A.I.R.C.H, All India Institute of Medical Sciences, New Delhi, India. batraatul85@gmail.com.
Papers in Europe PMC - 02
- 03Kaushal S2 papers · 2024
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
Papers in Europe PMC - 04Kumar S2 papers · 2024
Department of Medical Oncology, Dr B.R.A.I.R.C.H, All India Institute of Medical Sciences, New Delhi, India.
Papers in Europe PMC - 05Paterson RF2 papers · 1998
Department of Surgery, Division of Urology, University of British Columbia, Vancouver, BC.
Papers in Europe PMC - 06Pathak N2 papers · 2024
Department of Medical Oncology, Dr B.R.A.I.R.C.H, All India Institute of Medical Sciences, New Delhi, India.
Papers in Europe PMC - 07Raj A2 papers · 2024
Department of Medical Oncology, Dr B.R.A.I.R.C.H, All India Institute of Medical Sciences, New Delhi, India.
Papers in Europe PMC - 08Ray M2 papers · 2024
Department of Surgical Oncology, Dr B.R.A.I.R.C.H, All India Institute of Medical Sciences, New Delhi, India.
Papers in Europe PMC - 09Seth A2 papers · 2024
Department of Urology, All India Institute of Medical Sciences, New Delhi, India.
Papers in Europe PMC - 10Singh P2 papers · 2024
Department of Urology, All India Institute of Medical Sciences, New Delhi, India.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
3
interventional trials for this specific condition
3 interventional trials matched this specific condition name; 1 currently recruiting in our sample.
Data as of 27 July 2026
3 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 85.1th percentile).
high confidence · 85.1th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
3 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT07218913·RECRUITING·Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors
Conditions: Hearing Loss · Metastatic Malignant Germ Cell Tumor · Metastatic Malignant Nongerminomatous Germ Cell Tumor · Metastatic Malignant Testicular Non-Seminomatous Germ Cell Tumor·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Non-seminomatous germ cell tumor of testis" OR "Non-seminomatous germ cell tumor of the testis" OR "Non-dysgerminomatous germ cell tumor of testis" OR "Non-dysgerminomatous germ cell tumor of the testis" OR "Testicular non seminomatous germ cell tumor" OR "Testicular non-dysgerminomatous germ cell tumor" OR "non-dysgerminomatous germ cell tumour of testis" OR "non-dysgerminomatous germ cell tumour of the testis" OR "non-seminomatous germ cell tumour of testis" OR "non-seminomatous germ cell tumour of the testis" OR "testicular germ cell tumor non-seminomatous" OR "testicular germ cell tumour non-seminomatous" OR "testicular non seminomatous germ cell tumour" OR "testicular non-dysgerminomatous germ cell tumour" OR "testicular non-seminomatous germ cell tumor"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Non-seminomatous germ cell tumor of testis" OR "Non-seminomatous germ cell tumor of the testis" OR "Non-dysgerminomatous germ cell tumor of testis" OR "Non-dysgerminomatous germ cell tumor of the testis" OR "Testicular non seminomatous germ cell tumor" OR "Testicular non-dysgerminomatous germ cell tumor" OR "non-dysgerminomatous germ cell tumour of testis" OR "non-dysgerminomatous germ cell tumour of the testis" OR "non-seminomatous germ cell tumour of testis" OR "non-seminomatous germ cell tumour of the testis" OR "testicular germ cell tumor non-seminomatous" OR "testicular germ cell tumour non-seminomatous" OR "testicular non seminomatous germ cell tumour" OR "testicular non-dysgerminomatous germ cell tumour" OR "testicular non-seminomatous germ cell tumor"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 3 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T14:36:47.174Z