ORPHA:357107
Arterial thoracic outlet syndrome
Also known as: ATOS · Arterial TOS · Arterial cervical rib syndrome · Arterial costoclavicular syndrome · Arterial hyperabduction syndrome · Arterial scalenus anticus syndrome · Arterial thoracic outlet compression syndrome
Publications
373
83.6th percentile
Trials
0
Interventional, condition-specific
Researchers
909
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A form of thoracic outlet syndrome that presents as unilateral upper extremity ischemia.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0018164
- UMLS:C1956395
Additional Mondo synonyms (6)
arterial TOS · arterial cervical rib syndrome · arterial costoclavicular syndrome · arterial hyperabduction syndrome · arterial scalenus anticus syndrome · arterial thoracic outlet compression syndrome
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
373 matched papers (277 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPartial
None under the specific name; 15 for broader category thoracic outlet syndrome
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
373
373 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
373 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
277 in the last 10 years · medium confidence · 83.6th percentile (publications denominator)
Phrase hits: 373 · MeSH hits: 0
Who's working on it?
909
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Thompson RW7 papers · 2023
Center for Thoracic Outlet Syndrome and the Section of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Papers in Europe PMC - 02Gelabert HA6 papers · 2025
Division of Vascular & Endovascular Surgery, David Geffen School of Medicine at UCLA, Ronald Reagan Medical Center, University of California Los Angeles, Los Angeles, California.
Papers in Europe PMC - 03Freischlag JA4 papers · 2023
Wake Forest Baptist Medical Center, Wake Forest School of Medicine, Winston-Salem, NC.
Papers in Europe PMC - 04Kocher GJ4 papers · 2022
Klinik für Thoraxchirurgie, Inselspital, Universitätsspital Bern, Bern.
Papers in Europe PMC - 05Lum YW4 papers · 2024
Division of Vascular Surgery and Endovascular Therapy, Johns Hopkins University School of Medicine, Baltimore, Md.
Papers in Europe PMC - 06Minervini F4 papers · 2024
Department of Thoracic Surgery, Kantonsspital Luzern, 6004 Lucerne, Switzerland.
Papers in Europe PMC - 07Teijink JAW4 papers · 2023
Department of Vascular Surgery, Catharina Hospital, Eindhoven; Care and Public Health Research Institute School for Public Health and Primary Care, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht. Electronic address: joep.teijink@catharinaziekenhuis.nl.
Papers in Europe PMC - 08Abraham P3 papers · 2024
Service of Sports Medicine, University Hospital, 49100 Angers, France.
Papers in Europe PMC - 09de Borst GJ3 papers · 2026
Department of Vascular Surgery, University Medical Center, Utrecht, Netherlands.
Papers in Europe PMC - 10Donahue DM3 papers · 2024
Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Mass.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present). 15 trials are registered for thoracic outlet syndrome, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
medium confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
15 interventional trials matched thoracic outlet syndrome, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: thoracic outlet syndrome
15
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT07535853·NOT YET RECRUITING·Effect of Low-Power Laser Therapy on Pain and Functional Outcomes in Patients With Thoracic Outlet Syndrome
Conditions: Thoracic Outlet Syndrome·Matched via name phrase
- NCT07668206·NOT YET RECRUITING·Motivational Interviewing in Thoracic Outlet Syndrome
Conditions: Thoracic Outlet Syndrome·Matched via name phrase
- NCT05544721·ENROLLING BY INVITATION·A Study of Paravertebral Block in Thoracic Outlet Syndrome
Conditions: Thoracic Outlet Syndrome·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Arterial thoracic outlet syndrome" OR "Arterial TOS" OR "Arterial cervical rib syndrome" OR "Arterial costoclavicular syndrome" OR "Arterial hyperabduction syndrome" OR "Arterial scalenus anticus syndrome" OR "Arterial thoracic outlet compression syndrome"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Arterial thoracic outlet syndrome" OR "Arterial TOS" OR "Arterial cervical rib syndrome" OR "Arterial costoclavicular syndrome" OR "Arterial hyperabduction syndrome" OR "Arterial scalenus anticus syndrome" OR "Arterial thoracic outlet compression syndrome"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"thoracic outlet syndrome"
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: ATOS
Confidence reasoning
- Preferred label is multi-word and distinctive
- 1 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T14:31:48.487Z