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ORPHA:353253

Burning mouth syndrome

low confidenceDisorder

Also known as: BMS · Oral dysesthesia · Orodynia · Stomatodynia · Stomatopyrosis

Publications

3,497

Trials

38

Interventional, condition-specific

Researchers

829

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

A rare neurologic disease characterized by an unremitting bilateral symmetrical burning sensation of the oral mucosa without clinical evidence of causative lesions. It most frequently occurs in postmenopausal women and typically affects the tongue, less often the palate, lips, or buccal mucosa. It is often associated with dysgeusia and xerostomia.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (2)

oral dysesthesia · stomatodynia

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    3,497 matched papers (2,107 in last 10 years) Source

  3. Phenotype characterisedPresent

    17 HPO annotations (e.g. Abnormality of taste sensation; Anxiety; Depression) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    38 matched on ClinicalTrials.gov (4 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

17

Associated phenotypes · MONDO:0006687

  • Abnormality of taste sensation
  • Anxiety
  • Depression
  • Tongue pain
  • Abnormality of the gingiva

Showing 5 of 17 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

31

Drugs / clinical candidates · MONDO_0006687

CTD chemicals (MyDisease.info)

5 associated chemicals. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • Paroxetine · therapeutic
  • candesartan · marker/mechanism
  • Lamivudine · marker/mechanism
  • Nevirapine · marker/mechanism
  • Zidovudine · marker/mechanism

MyDisease.info · MONDO:0006687

Literature

Is anyone studying this?

3,497

3,497 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

3,497 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

2,107 in the last 10 years · low confidence

Phrase hits: 3,497 · MeSH hits: 147

Open Europe PMC search

Who's working on it?

829

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Nagamine T13 papers · 2026

    Sunlight Brain Research Center, 4-13-18 Jiyugaoka, Hofu, Yamaguchi 747-0066, Japan. Electronic address: tnagamine@outlook.com.

    Papers in Europe PMC
  2. 02
    Adamo D11 papers · 2026

    Department of Neuroscience, Reproductive and Odontostomatological Sciences, Oral Medicine Unit, University of Naples Federico II, Naples, Italy.

    Papers in Europe PMC
  3. 03
    Toyofuku A11 papers · 2026

    Department of Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences Institute of Science Tokyo Tokyo Japan.

    Papers in Europe PMC
  4. 04
    Mignogna MD10 papers · 2026

    Department of Neuroscience, Reproductive and Odontostomatological Sciences, Oral Medicine Unit, University of Naples Federico II, Naples, Italy.

    Papers in Europe PMC
  5. 05
    Suga T9 papers · 2026

    Department of Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences Institute of Science Tokyo Tokyo Japan.

    Papers in Europe PMC
  6. 06
    Canfora F7 papers · 2026

    Department of Neuroscience, Reproductive and Odontostomatological Sciences, Oral Medicine Unit, University of Naples Federico II, Naples, Italy.

    Papers in Europe PMC
  7. 07
    Watanabe M6 papers · 2026

    Department of Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences Institute of Science Tokyo Tokyo Japan.

    Papers in Europe PMC
  8. 08
    Boucher Y5 papers · 2026

    UFR Odontologie, Université Paris Cité, Paris, France.

    Papers in Europe PMC
  9. 09
    Lebel A5 papers · 2026

    UFR Odontologie, Université Paris Cité, Paris, France.

    Papers in Europe PMC
  10. 10
    Li X5 papers · 2026

    Department of Periodontics and Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical University, Luzhou, China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

38

interventional trials for this specific condition

38 interventional trials matched this specific condition name; 4 currently recruiting in our sample.

Data as of 11 September 2026

38 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 96.6th percentile).

low confidence · 96.6th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

38 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

8 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 11 · after dedupe 11 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 11 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (11)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Burning mouth syndrome — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Burning mouth syndrome" OR "Oral dysesthesia" OR "Orodynia" OR "Stomatodynia" OR "Stomatopyrosis"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Burning Mouth Syndrome

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Burning mouth syndrome" OR "Oral dysesthesia" OR "Orodynia" OR "Stomatodynia" OR "Stomatopyrosis"

Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 38 interventional · 8 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: BMS

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (3497) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T14:24:29.116Z