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ORPHA:340

Hemorrhagic fever-renal syndrome

high confidenceDisorder

Also known as: Hantavirosis · Hantavirus fever

Publications

247

63.5th percentile

Trials

0

Interventional, condition-specific

Researchers

1,120

Distinct authors in sample

Gene link

—

Readiness

4/6

Stages with a signal

Clinical definition (Orphanet)

A rare rodent-borne, potentially severe, hemorrhagic disease caused by Old World Hantaviruses characterized by high fever, malaise, headache, myalgia, arthralgia, backache, abdominal pain, oliguria/renal failure and systemic hemorrhagic manifestations.

How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

4/6 stages with a signal

No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    247 matched papers (149 in last 10 years) Source

  3. Phenotype characterisedPresent

    60 HPO annotations (e.g. Decreased glomerular filtration rate; Palpitations; Increased total leukocyte count) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationPresent

    1 FDA designation (1 FDA orphan-indication approval) — e.g. ribavirin Source

  6. Interventional trialPartial

    None under the specific name; 62 for broader category hemorrhagic fever

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

60

Associated phenotypes · MONDO:0018081

  • Decreased glomerular filtration rate
  • Palpitations
  • Increased total leukocyte count
  • Vomiting
  • Nausea

Showing 5 of 60 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

1

Designation · 1 with FDA orphan-indication approval

  • FDA ribavirinHemorrhagic Fever with Renal Syndrome · 1991-04-12 · Not FDA Approved for Orphan Indication

Sources: FDA OOPD · EMA orphan designations

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

1 associated chemical. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • Ribavirin · therapeutic

MyDisease.info · MONDO:0018081

Literature

Is anyone studying this?

247

247 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

247 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

149 in the last 10 years · high confidence · 63.5th percentile (publications denominator)

Phrase hits: 247 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,120

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.

  1. 01
    Price SJ9 papers · 2023

    Institute of Zoology, Zoological Society of London, London, United Kingdom.

    Papers in Europe PMC
  2. 02
    Garner TWJ8 papers · 2025

    Institute of Zoology, Zoological Society of London, London, United Kingdom.

    Papers in Europe PMC
  3. 03
    Bosch J6 papers · 2025

    Museo Nacional de Ciencias Naturales, CSIC, Madrid, Spain.

    Papers in Europe PMC
  4. 04
    Horta MAP5 papers · 2024

    Biosafety Level 3 Facility (BSL-3), Oswaldo Cruz Foundation, Rio de Janeiro RJ 21040-900, Brazil

    Papers in Europe PMC
  5. 05
    Lemos ERS5 papers · 2022

    Hantavirosis and Rickettsiosis Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro RJ 21040-900, Brazil

    Papers in Europe PMC
  6. 06
    Leung WTM5 papers · 2023

    Institute of Zoology, Zoological Society of London, London, United Kingdom.

    Papers in Europe PMC
  7. 07
    Nichols RA5 papers · 2022

    School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, UK. r.a.nichols@qmul.ac.uk.

    Papers in Europe PMC
  8. 08
    Sergeant C5 papers · 2022

    Institute of Zoology, Zoological Society of London, London, United Kingdom.

    Papers in Europe PMC
  9. 09
    Balloux F4 papers · 2022

    UCL Genetics Institute, University College London, Gower Street, London WC1E 6BT, UK.

    Papers in Europe PMC
  10. 10
    Cunningham AA4 papers · 2023

    Institute of Zoology, Zoological Society of London, London, United Kingdom.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

0

interventional trials for this specific condition

No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present). 62 trials are registered for hemorrhagic fever, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 11 September 2026 · last trial check 11 September 2026

No matched interventional trials. This is true for 77.2% of diseases in the trials denominator (5501 of 7126). Here are the researchers publishing on it.

high confidence · 38.6th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.

62 interventional trials matched hemorrhagic fever, the broader category — listed below. Those studies are not counted in the condition-specific total.

Broader category: hemorrhagic fever

62

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 1 · after dedupe 1 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 1 · dropped 0 · fetched 2026-07-29

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (1)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Hemorrhagic fever-renal syndrome — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Hemorrhagic fever-renal syndrome" OR "Hantavirosis" OR "Hantavirus fever"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Hemorrhagic fever-renal syndrome" OR "Hantavirosis" OR "Hantavirus fever"

Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"hemorrhagic fever"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-26T13:28:41.306Z