ORPHA:340
Hemorrhagic fever-renal syndrome
Also known as: Hantavirosis · Hantavirus fever
Publications
247
73.8th percentile
Trials
0
Interventional, condition-specific
Researchers
1,120
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A rare rodent-borne, potentially severe, hemorrhagic disease caused by Old World Hantaviruses characterized by high fever, malaise, headache, myalgia, arthralgia, backache, abdominal pain, oliguria/renal failure and systemic hemorrhagic manifestations.
How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0018081
- MeSH:C535630
- UMLS:C0019101
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
247 matched papers (149 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPartial
None under the specific name; 62 for broader category hemorrhagic fever
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
247
247 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
247 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
149 in the last 10 years · high confidence · 73.8th percentile (publications denominator)
Phrase hits: 247 · MeSH hits: 0
Who's working on it?
1,120
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Price SJ9 papers · 2023
Institute of Zoology, Zoological Society of London, London, United Kingdom.
Papers in Europe PMC - 02Garner TWJ8 papers · 2025
Institute of Zoology, Zoological Society of London, London, United Kingdom.
Papers in Europe PMC - 03Bosch J6 papers · 2025
Museo Nacional de Ciencias Naturales, CSIC, Madrid, Spain.
Papers in Europe PMC - 04Horta MAP5 papers · 2024
Biosafety Level 3 Facility (BSL-3), Oswaldo Cruz Foundation, Rio de Janeiro RJ 21040-900, Brazil
Papers in Europe PMC - 05Lemos ERS5 papers · 2022
Hantavirosis and Rickettsiosis Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro RJ 21040-900, Brazil
Papers in Europe PMC - 06Leung WTM5 papers · 2023
Institute of Zoology, Zoological Society of London, London, United Kingdom.
Papers in Europe PMC - 07Nichols RA5 papers · 2022
School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, UK. r.a.nichols@qmul.ac.uk.
Papers in Europe PMC - 08Sergeant C5 papers · 2022
Institute of Zoology, Zoological Society of London, London, United Kingdom.
Papers in Europe PMC - 09Balloux F4 papers · 2022
UCL Genetics Institute, University College London, Gower Street, London WC1E 6BT, UK.
Papers in Europe PMC - 10Cunningham AA4 papers · 2023
Institute of Zoology, Zoological Society of London, London, United Kingdom.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present). 62 trials are registered for hemorrhagic fever, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
62 interventional trials matched hemorrhagic fever, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: hemorrhagic fever
62
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT07543458·NOT YET RECRUITING·Therapeutics for Moderate and Severe Dengue
Conditions: Dengue · Severe Dengue · Mosquito-Borne Diseases · Vector Borne Diseases·Matched via name phrase
- NCT06860334·NOT YET RECRUITING·UMIT-2 - Adaptive Phase IIb Platform Trial to Determine the Efficacy and Safety of Therapeutics for CCHF
Conditions: Crimean-Congo Hemorrhagic Fever·Matched via name phrase
- NCT06799013·RECRUITING·Safety and Immunogenicity of a Self-Amplifying RNA Vaccine Against Crimean-Congo Hemorrhagic Fever
Conditions: Vaccine · Crimean-Congo Hemorrhagic Fever·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Hemorrhagic fever-renal syndrome" OR "Hantavirosis" OR "Hantavirus fever"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Hemorrhagic fever-renal syndrome" OR "Hantavirosis" OR "Hantavirus fever"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"hemorrhagic fever"
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-26T13:28:41.306Z