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ORPHA:3384

Common arterial trunk

low confidenceDisorder

Also known as: CAT · Common aorticopulmonary trunk · Common truncus arteriosus · Persistent truncus arteriosus · Truncus arteriosus · Truncus arteriosus communis

Publications

7,466

Trials

5

Interventional, condition-specific

Researchers

1,227

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare cardiac characterized by a single arterial trunk arising from the heart, giving origin sequentially to the coronary arteries, one or more pulmonary arteries, and the systemic arterial circulation. Two forms exist: common arterial trunk (CAT) with aortic dominance (unobstructed aortic arch) and one or both pulmonary arteries originating from the trunk, and CAT with pulmonary dominance and interrupted aortic arch or coarctation.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (8)

TAC · Truncus Arteriosus · common aorticopulmonary trunk · common arterial trunk · common truncus arteriosus · persistent truncus arteriosus · persistent truncus arteriosus (disease) · truncus arteriosus

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    7,466 matched papers (3,516 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    5 matched on ClinicalTrials.gov (3 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

7,466

7,466 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

7,466 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

3,516 in the last 10 years · low confidence

Phrase hits: 7,466 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,227

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Hörer J6 papers · 2026

    Department of Congenital and Pediatric Heart Surgery, https://ror.org/04hbwba26TUM University Hospital, German Heart Centre, Munich, Germany.

    Papers in Europe PMC
  2. 02
    Ewert P5 papers · 2026

    Department of Congenital Heart Disease and Pediatric Cardiology, TUM University Hospital, German Heart Center, Munich, Germany.

    Papers in Europe PMC
  3. 03
    Wang Y5 papers · 2026

    Health Science Center, Ningbo University Ningbo 315211, Zhejiang, China.

    Papers in Europe PMC
  4. 04
    Berg C4 papers · 2025

    Division of Prenatal Medicine, Department of Obstetrics and Gynecology, University of Cologne, Kerpenerstr. 34, 50931, Cologne, Germany.

    Papers in Europe PMC
  5. 05
    Breckpot J4 papers · 2026

    Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium.

    Papers in Europe PMC
  6. 06
    Digilio MC4 papers · 2026

    Medical Genetics Unit, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

    Papers in Europe PMC
  7. 07
    Emanuel BS4 papers · 2026

    Division of Human Genetics and Molecular Biology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

    Papers in Europe PMC
  8. 08
    Geipel A4 papers · 2024

    Department of Obstetrics and Prenatal Medicine, University of Bonn, Bonn, Germany.

    Papers in Europe PMC
  9. 09
    Gembruch U4 papers · 2024

    Department of Obstetrics and Prenatal Medicine, University of Bonn, Bonn, Germany.

    Papers in Europe PMC
  10. 10
    Gottschalk I4 papers · 2025

    Division of Prenatal Medicine, Department of Obstetrics and Gynecology, University of Cologne, Kerpenerstr. 34, 50931, Cologne, Germany. ingo.gottschalk@uk-koeln.de.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

5

interventional trials for this specific condition

5 interventional trials matched this specific condition name; 3 currently recruiting in our sample.

Data as of 27 July 2026

5 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 87.9th percentile).

low confidence · 87.9th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

5 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

2 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Common arterial trunk" OR "Common aorticopulmonary trunk" OR "Common truncus arteriosus" OR "Persistent truncus arteriosus" OR "Truncus arteriosus" OR "Truncus arteriosus communis" OR "persistent truncus arteriosus (disease)"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Common arterial trunk" OR "Common aorticopulmonary trunk" OR "Common truncus arteriosus" OR "Persistent truncus arteriosus" OR "Truncus arteriosus" OR "Truncus arteriosus communis" OR "persistent truncus arteriosus (disease)"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 5 interventional · 2 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: CAT; TAC

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 2 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (7466) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-26T23:03:30.164Z