ORPHA:3384
Common arterial trunk
Also known as: CAT · Common aorticopulmonary trunk · Common truncus arteriosus · Persistent truncus arteriosus · Truncus arteriosus · Truncus arteriosus communis
Publications
7,466
Trials
5
Interventional, condition-specific
Researchers
1,227
Distinct authors in sample
Gene link
—
Readiness
3/6
Stages with a signal
Clinical definition (Orphanet)
A rare cardiac characterized by a single arterial trunk arising from the heart, giving origin sequentially to the coronary arteries, one or more pulmonary arteries, and the systemic arterial circulation. Two forms exist: common arterial trunk (CAT) with aortic dominance (unobstructed aortic arch) and one or both pulmonary arteries originating from the trunk, and CAT with pulmonary dominance and interrupted aortic arch or coarctation.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0018072
- MeSH:D014339
- UMLS:C0041207
- NCIT:C98880
Additional Mondo synonyms (8)
TAC · Truncus Arteriosus · common aorticopulmonary trunk · common arterial trunk · common truncus arteriosus · persistent truncus arteriosus · persistent truncus arteriosus (disease) · truncus arteriosus
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
3/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
7,466 matched papers (3,516 in last 10 years) Source
- Phenotype characterisedPresent
37 HPO annotations (e.g. Right ventricular hypertrophy; Right aortic arch; Pulmonic stenosis) Source
- Animal modelNot found
No Alliance genotype “model of” associations via Monarch for these Mondo IDs
- Orphan designationNot found
No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source
- Interventional trialPresent
5 matched on ClinicalTrials.gov (3 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
37
Associated phenotypes · MONDO:0018072
- Right ventricular hypertrophy
- Right aortic arch
- Pulmonic stenosis
- Patent ductus arteriosus
- Abnormal facial shape
Showing 5 of 37 — open Monarch for the full list.
Animal models (Monarch / Alliance)
None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.
Monarch fetch 2026-07-29
Therapies
Designations, candidates, and chemicals
FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.
Orphan designation (FDA · EMA)
No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.
Open Targets candidates
No drugs or clinical candidates returned for this Mondo ID on Open Targets.
CTD chemicals (MyDisease.info)
2 associated chemicals · 1 pathway. Therapeutic evidence is listed first when present — not a treatment recommendation.
- Aspirin · marker/mechanism
- Leflunomide · marker/mechanism
Pathways: Axon guidance
Literature
Is anyone studying this?
7,466
7,466 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.
7,466 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).
3,516 in the last 10 years · low confidence
Phrase hits: 7,466 · MeSH hits: 0
Who's working on it?
1,227
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Hörer J6 papers · 2026
Department of Congenital and Pediatric Heart Surgery, https://ror.org/04hbwba26TUM University Hospital, German Heart Centre, Munich, Germany.
Papers in Europe PMC - 02Ewert P5 papers · 2026
Department of Congenital Heart Disease and Pediatric Cardiology, TUM University Hospital, German Heart Center, Munich, Germany.
Papers in Europe PMC - 03Wang Y5 papers · 2026
Health Science Center, Ningbo University Ningbo 315211, Zhejiang, China.
Papers in Europe PMC - 04Berg C4 papers · 2025
Division of Prenatal Medicine, Department of Obstetrics and Gynecology, University of Cologne, Kerpenerstr. 34, 50931, Cologne, Germany.
Papers in Europe PMC - 05Breckpot J4 papers · 2026
Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Papers in Europe PMC - 06Digilio MC4 papers · 2026
Medical Genetics Unit, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Papers in Europe PMC - 07Emanuel BS4 papers · 2026
Division of Human Genetics and Molecular Biology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Papers in Europe PMC - 08Geipel A4 papers · 2024
Department of Obstetrics and Prenatal Medicine, University of Bonn, Bonn, Germany.
Papers in Europe PMC - 09Gembruch U4 papers · 2024
Department of Obstetrics and Prenatal Medicine, University of Bonn, Bonn, Germany.
Papers in Europe PMC - 10Gottschalk I4 papers · 2025
Division of Prenatal Medicine, Department of Obstetrics and Gynecology, University of Cologne, Kerpenerstr. 34, 50931, Cologne, Germany. ingo.gottschalk@uk-koeln.de.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
5
interventional trials for this specific condition
5 interventional trials matched this specific condition name; 3 currently recruiting in our sample.
Data as of 11 September 2026
5 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 89.2th percentile).
low confidence · 89.2th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
5 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT06771687·RECRUITING·High Intensity Interval Training in Patients With a Right Ventricle to Pulmonary Artery Conduit
Not reviewed·Conditions: Congenital Heart Disease · Truncus Arteriosus · Pulmonary Atresia · Tetralogy of Fallot·Matched via name phrase
- NCT05809310·RECRUITING·Effects Branch PA Stenting d-TGA, ToF and TA
Not reviewed·Conditions: Transposition of Great Vessels · Tetralogy of Fallot · Truncus Arteriosus · Pulmonary Artery Stenosis Supravalvular Congenital·Matched via name phrase
- NCT05452720·RECRUITING·MASA Valve Early Feasibility Study
Not reviewed·Conditions: Tetrology of Fallot · Pulmonary Stenosis · Truncus Arteriosus · Transposition of Great Vessels·Matched via name phrase
Observational and natural-history studies
2 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT06768008·RECRUITING·An Integrated Prenatal and Postnatal Treatment Model for the Treatment of Newborns With Critical Congenital Heart Disease
Not reviewed·Conditions: Congenital Heart Disease · Coarctation of Aorta · Aortic Stenosis · Pulmonary Atresia·Matched via name phrase
Other registries (secondary)
Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.
raw 5 · after dedupe 5 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 5 · dropped 0 · fetched 2026-07-29
Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri
No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).
Uncertain / not reviewed (5)
- isrctn·ISRCTN15774307·No longer recruiting·Standardisation, acceptability and outcomes of elective (planned) caesarean births where the baby's head is delivered first, and the baby is not fully delivered until after they have taken their first cry or 2 minutes have passed (whichever is sooner)
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN16716994·No longer recruiting·Endovascular treatment of aortic arch chronic dissection with a branched endograft following previous ascending aorta replacement for Acute Type A dissection: midterm results from an international multicenter study
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN15816734·No longer recruiting·The effect of home electrical stimulation and intra-operative femoral nerve blockage on outcomes after anterior cruciate ligament reconstruction
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN37255045·Stopped·Can brachial artery peak velocity variation and changes in this parameter in response to passive leg raising be used as a marker to predict fluid responsiveness in spontaneously breathing septic patients?
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN15169433·No longer recruiting·A phase II clinical trial to investigate the safety, tolerability and efficacy of TransCon CNP, weekly subcutaneous injections, compared with placebo, in infants with achondroplasia
skipped — LLM skipped (--skip-llm)
Where to find support
Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.
Orphanet entry for Common arterial trunk — check Associations / patient organisations on that page.
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Common arterial trunk" OR "Common aorticopulmonary trunk" OR "Common truncus arteriosus" OR "Persistent truncus arteriosus" OR "Truncus arteriosus" OR "Truncus arteriosus communis" OR "persistent truncus arteriosus (disease)"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Common arterial trunk" OR "Common aorticopulmonary trunk" OR "Common truncus arteriosus" OR "Persistent truncus arteriosus" OR "Truncus arteriosus" OR "Truncus arteriosus communis" OR "persistent truncus arteriosus (disease)"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 5 interventional · 2 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: CAT; TAC
Confidence reasoning
- Preferred label is multi-word and distinctive
- 2 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
- Publication count (7466) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-26T23:03:30.164Z