ORPHA:33577
Nodular non-suppurative panniculitis
Also known as: Idiopathic lobular panniculitis · Idiopathic nodular panniculitis · Pfeiffer-Weber-Christian syndrome · Relapsing febrile nodular nonsuppurative panniculitis · Relapsing febrile nodular panniculitis · WCD · Weber-Christian disease · Weber-Christian panniculitis
Publications
775
67.7th percentile
Trials
0
Interventional, condition-specific
Researchers
827
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A rare skin disorder characterized by recurring inflammation in the subcutaneous layer of fat.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0018063
- MeSH:D010201
- UMLS:C0030328
Additional Mondo synonyms (3)
idiopathic lobular panniculitis · idiopathic nodular panniculitis · nodular nonsuppurative panniculitis
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
775 matched papers (107 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPartial
None under the specific name; 12 for broader category panniculitis
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
775
775 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
775 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
107 in the last 10 years · medium confidence · 67.7th percentile (publications denominator)
Phrase hits: 775 · MeSH hits: 0
Who's working on it?
827
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Noh G4 papers · 2026
Allergy and Clinical Immunology Center Cheju Halla General Hospital Jeju-si Korea.
Papers in Europe PMC - 02Oksi J3 papers · 1998
Department of Medicine, Turku University Central Hospital, Finland.
Papers in Europe PMC - 03Viljanen MK3 papers · 1998Papers in Europe PMC
- 04Ballantyne CM2 papers · 2025
Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Papers in Europe PMC - 05Brazzelli V2 papers · 2013Papers in Europe PMC
- 06Brisson D2 papers · 2025
Université de Montréal, Department of Medicine, Montreal, Canada.
Papers in Europe PMC - 07Duell PB2 papers · 2025
Knight Cardiovascular Institute and Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, OR, USA.
Papers in Europe PMC - 08Egorova ON2 papers · 2023
V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.
Papers in Europe PMC - 09Fraitag S2 papers · 2021
Paediatric Dermatopathology Unit, Department of Pathology, Hôpital Necker-Enfants Malades, APHP, 75015 Paris, France.
Papers in Europe PMC - 10Gaudet D2 papers · 2025
Université de Montréal, Department of Medicine, Montreal, Canada.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present). 12 trials are registered for panniculitis, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
medium confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
12 interventional trials matched panniculitis, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: panniculitis
12
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT07691450·NOT YET RECRUITING·Belinostat in Combination With Azacitidine or Pralatrexate for the Treatment of Relapse or Refractory T-cell Lymphoma
Conditions: Recurrent Anaplastic Large Cell Lymphoma · Recurrent Enteropathy-Associated T-Cell Lymphoma · Recurrent Follicular Helper T-Cell Lymphoma · Recurrent Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type·Matched via name phrase
- NCT05475925·RECRUITING·A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas
Conditions: LGLL - Large Granular Lymphocytic Leukemia · Primary Cutaneous Gamma-Delta T-Cell Lymphoma · Primary Cutaneous CD8+ Aggressive Epidermotropic T-Cell Lymphoma · Hepatosplenic T-cell Lymphoma·Matched via name phrase
- NCT06838988·RECRUITING·Ultrasonographic Patterns and Pathological Correlation in the Diagnosis of Subcutaneous Nodules
Conditions: Nodules · Ultrasonography · Panniculitis·Matched via name phrase
- NCT07055477·RECRUITING·A Phase I Trial Anti-CC Chemokine Receptor 4 Chimeric Antigen Receptor T Cells (CCR4 CAR T Cells) for CCR4 Expressing T-cell Malignancies Including Peripheral T-cell Non-Hodgkin Lymphoma (PTCL) and Cutaneous T-cell Non-Hodgkin Lymphoma (CTCL)
Conditions: Relapsed and/or Refractory Mature T Cell Malignancy · Peripheral T-Cell Lymphoma · Angioimmunoblastic T-cell Lymphoma · Anaplastic Large Cell Lymphoma·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Nodular non-suppurative panniculitis" OR "Idiopathic lobular panniculitis" OR "Idiopathic nodular panniculitis" OR "Pfeiffer-Weber-Christian syndrome" OR "Relapsing febrile nodular nonsuppurative panniculitis" OR "Relapsing febrile nodular panniculitis" OR "Weber-Christian disease" OR "Weber-Christian panniculitis" OR "nodular nonsuppurative panniculitis"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Nodular non-suppurative panniculitis" OR "Idiopathic lobular panniculitis" OR "Idiopathic nodular panniculitis" OR "Pfeiffer-Weber-Christian syndrome" OR "Relapsing febrile nodular nonsuppurative panniculitis" OR "Relapsing febrile nodular panniculitis" OR "Weber-Christian disease" OR "Weber-Christian panniculitis" OR "nodular nonsuppurative panniculitis"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"panniculitis"
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: WCD
Confidence reasoning
- Preferred label is multi-word and distinctive
- 1 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-26T23:38:41.900Z