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ORPHA:330064

Chronic actinic dermatitis

high confidenceDisorder

Also known as: Actinic reticuloid · Chronic photosensitivity dermatitis

Publications

727

76th percentile

Trials

1

Interventional, condition-specific

Researchers

888

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

Chronic actinic dermatitis (CAD) is an immunologically mediated photodermatosis usually observed in temperate climates and that typically develops in middle-aged to elderly males. CAD is characterized by eczematous and often lichenified pruritic patches and confluent plaques located predominantly on sun-exposed areas with notable sparing of eyelids, skin folds, and postauricular skin. It is often accompanied by multiple contact allergies and usually occurs in a background of either atopic, contact allergic, or seborrheic dermatitis, although it can occur de novo. Resolution of photosensitivity is reported in up to 50% of individuals after 15 years or more, with contact allergies persisting.

How rare: 1-5 / 10 000 — about one to five people per ten thousand (still uncommon, but less ultra-rare).

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (2)

actinic reticuloid · chronic photosensitivity dermatitis

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    727 matched papers (303 in last 10 years) Source

  3. Phenotype characterisedPresent

    12 HPO annotations (e.g. Epidermal acanthosis; Late onset atopic dermatitis; Eczematoid dermatitis) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    1 matched on ClinicalTrials.gov

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

12

Associated phenotypes · MONDO:0018025

  • Epidermal acanthosis
  • Late onset atopic dermatitis
  • Eczematoid dermatitis
  • Pruritus
  • Cutaneous photosensitivity

Showing 5 of 12 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

727

727 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

727 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

303 in the last 10 years · high confidence · 76th percentile (publications denominator)

Phrase hits: 727 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

888

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Tu Y10 papers · 2025

    Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China; Department of Dermatology, The Second People's Hospital of Guiyang, Guizhou, 550000, China.

    Papers in Europe PMC
  2. 02
    He L7 papers · 2025

    Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. Electronic address: drheli2662@126.com.

    Papers in Europe PMC
  3. 03
    Lim HW5 papers · 2023

    Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.

    Papers in Europe PMC
  4. 04
    Wu W5 papers · 2023

    Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.

    Papers in Europe PMC
  5. 05
    Chaiyabutr C4 papers · 2025

    Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

    Papers in Europe PMC
  6. 06
    Huang X4 papers · 2026

    Department of Dermatology, Zhongshan Second People's Hospital, Zhongshan, Guangdong, China.

    Papers in Europe PMC
  7. 07
    Li X4 papers · 2026

    Department of Dermatology, People's Hospital of Chuxiong Yi Autonomous Prefecture, Chuxiong, 675000, China.

    Papers in Europe PMC
  8. 08
    Wang L4 papers · 2025

    Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.

    Papers in Europe PMC
  9. 09
    Xu D4 papers · 2024

    Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.

    Papers in Europe PMC
  10. 10
    Chai Y3 papers · 2023

    Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

1

interventional trials for this specific condition

1 interventional trial matched this specific condition name; none in our sample are currently recruiting.

Data as of 11 September 2026

1 interventional trial — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 80.1th percentile).

high confidence · 80.1th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

1 interventional trials matched after quoted-phrase search and title/condition post-filter.

No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 7 · after dedupe 7 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 7 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (7)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Chronic actinic dermatitis — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Chronic actinic dermatitis" OR "Actinic reticuloid" OR "Chronic photosensitivity dermatitis"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Chronic actinic dermatitis" OR "Actinic reticuloid" OR "Chronic photosensitivity dermatitis"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 1 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T14:06:33.932Z