ORPHA:329984
Goblet cell carcinoma
Also known as: GCC · Goblet cell adenocarcinoid · Goblet cell carcinoid · Goblet cell tumor
Publications
1,632
Trials
0
Interventional, condition-specific
Researchers
1,233
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
Goblet cell carcinoma (GCC) is an aggressive type of endocrine tumor of the appendix presenting equally in males and females in the fifth decade of life and manifesting with a palpable mass and abdominal pain or acute appendicitis. Metastasis to the ovaries, peritoneum or right colon has usually already occurred in half of patients at the time of diagnosis.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0018017
- UMLS:C0205695
- NCIT:C3689
Additional Mondo synonyms (19)
Goblet Cell Adenocarcinoma · appendix adenocarcinoid tumor · appendix adenocarcinoid tumour · appendix goblet cell carcinoid · appendix goblet cell carcinoid tumor · appendix goblet cell carcinoid tumour · appendix mixed carcinoid-adenocarcinoma · carcinoma of goblet cell · goblet cell adenocarcinoid · goblet cell carcinoid · goblet cell carcinoid of appendix · goblet cell carcinoid of the appendix · goblet cell carcinoid tumor · goblet cell carcinoid tumour · goblet cell carcinoma · goblet cell tumor · goblet cell tumour · mucinous carcinoid tumor · mucinous carcinoid tumour
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
1,632 matched papers (990 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
1,632
1,632 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
1,632 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
990 in the last 10 years · low confidence
Phrase hits: 1,632 · MeSH hits: 0
Who's working on it?
1,233
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Gill AJ3 papers · 2026
NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital St Leonards, Sydney, New South Wales, Australia.
Papers in Europe PMC - 02Reid MD3 papers · 2026
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta GA, USA.
Papers in Europe PMC - 03Ahuja N2 papers · 2023
Department of Surgical Oncology, Yale School of Medicine, Yale University School of Medicine, 330 Cedar Street, FMB130, New Haven, CT, 06520, USA.
Papers in Europe PMC - 04AlAli MN2 papers · 2025
Department of Surgery, Prince Mohammed bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia.
Papers in Europe PMC - 05Alnajjar JS2 papers · 2025
College of Medicine, King Faisal University, Alahsa, Saudi Arabia.
Papers in Europe PMC - 06Alrasheed AF2 papers · 2025
Department of Surgery, Prince Mohammed bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia.
Papers in Europe PMC - 07Bartlett DL2 papers · 2025
Allegheny Health Network Cancer Institute, Pittsburgh, PA 15212, USA.
Papers in Europe PMC - 08Blodgett R2 papers · 2025
Allegheny Health Network Cancer Institute, Pittsburgh, PA 15212, USA.
Papers in Europe PMC - 09Cecil T2 papers · 2026
Peritoneal Malignancy and Colorectal Surgery, Basingstoke and North Hampshire NHS Foundation Trust, The Ark, Aldermeston Road, Basingstoke RG24 9NA, United Kingdom.
Papers in Europe PMC - 10Chen H2 papers · 2026
Department of Cardiothoracic Surgery, School of Clinical Medicine, The First Affiliated Hospital of Chengdu Medical College, No. 278, Baoguang Road, Xindu District, Chengdu, 610500, Sichuan, China.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
low confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Goblet cell carcinoma" OR "Goblet cell adenocarcinoid" OR "Goblet cell carcinoid" OR "Goblet cell tumor" OR "Goblet Cell Adenocarcinoma" OR "appendix adenocarcinoid tumor" OR "appendix adenocarcinoid tumour" OR "appendix goblet cell carcinoid" OR "appendix goblet cell carcinoid tumor" OR "appendix goblet cell carcinoid tumour" OR "appendix mixed carcinoid-adenocarcinoma" OR "carcinoma of goblet cell" OR "carcinoma of the goblet cell" OR "goblet cell carcinoid of appendix" OR "goblet cell carcinoid of the appendix" OR "goblet cell carcinoid tumor" OR "goblet cell carcinoid tumour" OR "goblet cell tumour" OR "mucinous carcinoid tumor" OR "mucinous carcinoid tumour"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Goblet cell carcinoma" OR "Goblet cell adenocarcinoid" OR "Goblet cell carcinoid" OR "Goblet cell tumor" OR "Goblet Cell Adenocarcinoma" OR "appendix adenocarcinoid tumor" OR "appendix adenocarcinoid tumour" OR "appendix goblet cell carcinoid" OR "appendix goblet cell carcinoid tumor" OR "appendix goblet cell carcinoid tumour" OR "appendix mixed carcinoid-adenocarcinoma" OR "carcinoma of goblet cell" OR "carcinoma of the goblet cell" OR "goblet cell carcinoid of appendix" OR "goblet cell carcinoid of the appendix" OR "goblet cell carcinoid tumor" OR "goblet cell carcinoid tumour" OR "goblet cell tumour" OR "mucinous carcinoid tumor" OR "mucinous carcinoid tumour"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: GCC
Confidence reasoning
- Preferred label is multi-word and distinctive
- 1 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
- Publication count (1632) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-27T14:00:16.067Z