ORPHA:319667
Primary lymphoma of the conjunctiva
Also known as: Primary lymphoid conjunctival tumor
Publications
207
63.9th percentile
Trials
0
Interventional, condition-specific
Researchers
1,066
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
Primary lymphoma of the conjunctiva is an extremely rare clonal lymphoid proliferation of the ocular surface, with an indolent course. Clinically it presents with treatment-resistant conjunctivitis, ptosis, excessive tear production or as a painless, salmon-pink, ''fleshy'' patch, with a smooth or multinodular surface, on the bulbar conjunctiva. Histologically it is usually B-cell Non-Hodgkin lymphoma (most often extranodal marginal zone B-cell lymphoma, followed by follicular and diffuse large B-cell lymphoma), with conjunctival T-cell Non-Hodgkin lymphoma being very rare.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0017907
- UMLS:C4706485
- NCIT:C175432
Additional Mondo synonyms (6)
conjunctiva lymphoma · conjunctiva primary organ-specific lymphoma · lymphoma of conjunctiva · primary lymphoid conjunctival tumor · primary lymphoid conjunctival tumour · primary organ-specific lymphoma of conjunctiva
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
207 matched papers (86 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
207
207 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
207 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
86 in the last 10 years · high confidence · 63.9th percentile (publications denominator)
Phrase hits: 207 · MeSH hits: 0
Who's working on it?
1,066
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Coupland SE5 papers · 2023
Department of Pathology, University of Liverpool, Liverpool, UK.
Papers in Europe PMC - 02Mudhar HS4 papers · 2020
Department of Histopathology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK.
Papers in Europe PMC - 03Cho SG3 papers · 2021
Department of Hematology, Catholic University Lymphoma Group, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Papers in Europe PMC - 04Galor A3 papers · 2023
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, FL, USA; Department of Ophthalmology, Miami Veterans Administration Medical Center, Miami, FL, USA.
Papers in Europe PMC - 05Isaacson PG3 papers · 1995
Department of Histopathology, University College London Medical School.
Papers in Europe PMC - 06Karp CL3 papers · 2023
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, FL, USA. Electronic address: ckarp@med.miami.edu.
Papers in Europe PMC - 07Wang Y3 papers · 2024
Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
Papers in Europe PMC - 08Yang SW3 papers · 2021
Department of Ophthalmology, Catholic University Lymphoma Group, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Papers in Europe PMC - 09Aronow ME2 papers · 2022
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
Papers in Europe PMC - 10Auw-Hädrich C2 papers · 2023
Klinik für Augenheilkunde Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland. claudia.auw-haedrich@uniklinik-freiburg.de.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Primary lymphoma of the conjunctiva" OR "Primary lymphoma of conjunctiva" OR "Primary lymphoid conjunctival tumor" OR "conjunctiva lymphoma" OR "conjunctiva primary organ-specific lymphoma" OR "lymphoma of conjunctiva" OR "lymphoma of the conjunctiva" OR "primary lymphoid conjunctival tumour" OR "primary organ-specific lymphoma of conjunctiva" OR "primary organ-specific lymphoma of the conjunctiva"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Primary lymphoma of the conjunctiva" OR "Primary lymphoma of conjunctiva" OR "Primary lymphoid conjunctival tumor" OR "conjunctiva lymphoma" OR "conjunctiva primary organ-specific lymphoma" OR "lymphoma of conjunctiva" OR "lymphoma of the conjunctiva" OR "primary lymphoid conjunctival tumour" OR "primary organ-specific lymphoma of conjunctiva" OR "primary organ-specific lymphoma of the conjunctiva"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T13:31:42.308Z