RARE DISEASERESEARCH ATLAS
Open navigation menu

ORPHA:319276

Clear cell renal carcinoma

high confidenceDisorder

Also known as: CCRCC · Clear cell renal cell adenocarcinoma · Clear cell renal cell carcinoma

Publications

44,358

99.3th percentile

Trials

314

Interventional, condition-specific

Researchers

1,115

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

A rare renal tumor arising from proximal tubular epithelial cells of the renal cortex, characterized histologically by malignant epithelial cells with typical clear cytoplasm in conventional staining methods due to a high glycogen and lipid content, featuring a nested growth pattern. Clinically it may present with hematuria, flank pain, anemia or, less commonly, a palpable abdominal mass.

How rare: 1-9 / 100 000 — about one to nine people per hundred thousand.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (18)

Grawitz tumor · Grawitz tumour · RCC, clear cell adenocarcinoma · clear cell adenocarcinoma of kidney · clear cell adenocarcinoma of the kidney · clear cell adenocarcinoma, kidney · clear cell carcinoma of kidney · clear cell carcinoma of the kidney · clear cell renal cell cancer · clear cell renal cell carcinoma · conventional (clear cell) renal cell adenocarcinoma · conventional (clear cell) renal cell carcinoma · conventional renal cell carcinoma · kidney clear cell adenocarcinoma · kidney clear cell carcinoma · renal cell carcinoma, clear cell adenocarcinoma · renal clear cell adenocarcinoma · renal clear cell carcinoma

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    44,358 matched papers (36,770 in last 10 years) Source

  3. Phenotype characterisedNot found

    No HPO disease–phenotype associations via Monarch for these Mondo IDs

  4. Animal modelPresent

    1 genotype model (Danio rerio) Source

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    314 matched on ClinicalTrials.gov (98 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

None returned for this Mondo ID. That often means “not linked under this ID,” not “no clinical features.”

Animal models (Monarch / Alliance)

1

Model associations linked to this Mondo ID

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

106

Drugs / clinical candidates · MONDO_0005005

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

44,358

44,358 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

44,358 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

36,770 in the last 10 years · high confidence · 99.3th percentile (publications denominator)

Phrase hits: 44,358 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,115

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Wang Y14 papers · 2026

    Department of Radiology, Zhumadian Central Hospital Affiliated to Huanghuai University, Zhumadian, China. 18181239@qq.com.

    Papers in Europe PMC
  2. 02
    Li Y13 papers · 2026

    Department of Pathology and Laboratory Medicine School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.

    Papers in Europe PMC
  3. 03
    Wang J13 papers · 2026

    Senior Department of Urology, Chinese PLA General Hospital, Beijing, China.

    Papers in Europe PMC
  4. 04
    Zhang Y12 papers · 2026

    Department of Urology, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen 361004, Fujian, China; The Graduate School of Fujian Medical University, Fuzhou 350122, Fujian, China.

    Papers in Europe PMC
  5. 05
    Li J11 papers · 2026

    The First Clinical Medical School of Shanxi Medical University, No. 56 Xinjian South Road, Yingze District, Taiyuan, Shanxi 030001, China (D.L., J.L., Z.W., Z.G., H.F., J.G., W.S.); Department of Urology, First Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Yingze District, Taiyuan, Shanxi 030001, China (D.L., J.L., Z.W., Z.G., H.F., J.G., W.S.).

    Papers in Europe PMC
  6. 06
    Liu Y11 papers · 2026

    Department of Urology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, 510900, China.

    Papers in Europe PMC
  7. 07
    Chen J9 papers · 2026

    Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

    Papers in Europe PMC
  8. 08
    Li X9 papers · 2026

    Affiliated Meizhou Hospital of Shantou University Medical College, Meizhou, China.

    Papers in Europe PMC
  9. 09
    Zhang H9 papers · 2026

    The First College of Clinical Medical Science, China Three Gorges University, Yichang, P.R. China.

    Papers in Europe PMC
  10. 10
    Chen X8 papers · 2026

    Senior Department of Urology, Chinese PLA General Hospital, Beijing, China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

314

interventional trials for this specific condition

314 interventional trials matched this specific condition name; 98 currently recruiting in our sample.

Data as of 11 September 2026

314 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 99.6th percentile).

high confidence · 99.6th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

314 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

25 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 65 · after dedupe 65 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 65 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (65)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Clear cell renal carcinoma — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Clear cell renal carcinoma" OR "CCRCC" OR "Clear cell renal cell adenocarcinoma" OR "Clear cell renal cell carcinoma" OR "Grawitz tumor" OR "Grawitz tumour" OR "RCC, clear cell adenocarcinoma" OR "clear cell adenocarcinoma of kidney" OR "clear cell adenocarcinoma of the kidney" OR "clear cell adenocarcinoma, kidney" OR "clear cell carcinoma of kidney" OR "clear cell carcinoma of the kidney" OR "clear cell renal cell cancer" OR "conventional (clear cell) renal cell adenocarcinoma" OR "conventional (clear cell) renal cell carcinoma" OR "conventional renal cell carcinoma" OR "kidney clear cell adenocarcinoma" OR "kidney clear cell carcinoma" OR "renal cell carcinoma, clear cell adenocarcinoma" OR "renal clear cell adenocarcinoma" OR "renal clear cell carcinoma"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Clear cell renal carcinoma" OR "CCRCC" OR "Clear cell renal cell adenocarcinoma" OR "Clear cell renal cell carcinoma" OR "Grawitz tumor" OR "Grawitz tumour" OR "RCC, clear cell adenocarcinoma" OR "clear cell adenocarcinoma of kidney" OR "clear cell adenocarcinoma of the kidney" OR "clear cell adenocarcinoma, kidney" OR "clear cell carcinoma of kidney" OR "clear cell carcinoma of the kidney" OR "clear cell renal cell cancer" OR "conventional (clear cell) renal cell adenocarcinoma" OR "conventional (clear cell) renal cell carcinoma" OR "conventional renal cell carcinoma" OR "kidney clear cell adenocarcinoma" OR "kidney clear cell carcinoma" OR "renal cell carcinoma, clear cell adenocarcinoma" OR "renal clear cell adenocarcinoma" OR "renal clear cell carcinoma"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 314 interventional · 25 observational · 1 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T13:22:29.144Z