ORPHA:319251
Rift valley fever
Publications
9,765
Trials
8
Interventional, condition-specific
Researchers
1,513
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
Rift Valley fever (RVF), caused by the Rift Valley fever virus (RVFV), is an arbovirus characterized by a usually self-limiting febrile illness but that in some cases can also manifest with thrombosis, vision loss, hemorrhages and/or neurological symptoms.
How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0017880
- MeSH:D012295
- UMLS:C0035613
- NCIT:C128419
Additional Mondo synonyms (1)
RVF
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
9,765 matched papers (5,683 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
8 matched on ClinicalTrials.gov (1 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
9,765
9,765 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
9,765 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
5,683 in the last 10 years · low confidence
Phrase hits: 9,765 · MeSH hits: 405
Who's working on it?
1,513
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Nyakarahuka L12 papers · 2026
Uganda Virus Research Institute, Entebbe P.O. Box 49, Uganda.
Papers in Europe PMC - 02Bett B10 papers · 2026
International Livestock Research Institute, Nairobi, Kenya.
Papers in Europe PMC - 03Faye O7 papers · 2025
Virology Department, The Pasteur Institute of Dakar, Dakar, Senegal.
Papers in Europe PMC - 04Hartman AL6 papers · 2026
Center for Vaccine Research, University of Pittsburghgrid.21925.3d, Pittsburgh, Pennsylvania, USA.
Papers in Europe PMC - 05Njenga MK6 papers · 2026
Paul G Allen School for Global Health, Washington State University, Pullman, WA, USA.
Papers in Europe PMC - 06Situma S6 papers · 2026
Center for Research in Emerging Infectious Diseases East and Central Africa, Nairobi 00202, Kenya; (S.S.); (C.N.); (J.D.); (K.M.N.)
Papers in Europe PMC - 07Cleaveland S5 papers · 2026
Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom.
Papers in Europe PMC - 08Gaye A5 papers · 2025
Medical Zoology Department, The Pasteur Institute of Dakar, Dakar, Senegal.
Papers in Europe PMC - 09Juma J5 papers · 2026
Genomics Program, International Livestock Research Institute, Nairobi, Kenya.
Papers in Europe PMC - 10
Clinical research
Is a treatment being tested?
8
interventional trials for this specific condition
8 interventional trials matched this specific condition name; 1 currently recruiting in our sample.
Data as of 27 July 2026
8 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 90.6th percentile).
low confidence · 90.6th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
8 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT03609398·RECRUITING·Phase 2 Safety and Immunogenicity Study of Rift Valley Fever Vaccine
Conditions: Rift Valley Fever·Matched via name + MeSH
Observational and natural-history studies
3 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT07358910·RECRUITING·Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
Conditions: Dengue · Chikungunya · Zika Virus Infection · Japanese Encephalitis·Matched via name + MeSH
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Rift valley fever"
MeSH descriptor terms unioned into the query: Rift Valley Fever
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Rift valley fever"
Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 8 interventional · 3 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: RVF
Confidence reasoning
- Preferred label is multi-word and distinctive
- 1 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
- Publication count (9765) is implausibly high for prevalence class "<1 / 1 000 000" — treat as possible over-matching, not a measure of research intensity
Ingested 2026-07-27T13:21:05.280Z