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ORPHA:319218

Ebola hemorrhagic fever

low confidenceDisorder

Also known as: EHF · Ebola fever · Ebola virus disease

Publications

66,466

Trials

89

Interventional, condition-specific

Researchers

1,452

Distinct authors in sample

Gene link

—

Readiness

4/6

Stages with a signal

Clinical definition (Orphanet)

Ebola hemorrhagic fever (EHF), caused by Ebola virus, is a severe viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms, bleeding, shock, and multi-organ system failure.

How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (4)

Ebola · Ebolavirus caused disease or disorder · Ebolavirus disease or disorder · Ebolavirus infectious disease

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

4/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    66,466 matched papers (51,639 in last 10 years) Source

  3. Phenotype characterisedPresent

    32 HPO annotations (e.g. Gastrointestinal hemorrhage; Cough; Sepsis) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationPresent

    9 FDA · 4 EMA designations (8 FDA orphan-indication approvals) — e.g. ansuvimab Source

  6. Interventional trialPresent

    89 matched on ClinicalTrials.gov (5 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

32

Associated phenotypes · MONDO:0005737

  • Gastrointestinal hemorrhage
  • Cough
  • Sepsis
  • Dyspnea
  • Decreased total leukocyte count

Showing 5 of 32 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

13

Designations · 8 with FDA orphan-indication approval

  • FDA ansuvimabEbola Virus Infection · 2020-03-30 · Not FDA Approved for Orphan Indication
  • FDA quinacrineEbola Infection · 2019-09-10 · Not FDA Approved for Orphan Indication
  • FDA pyronaridine tetraphosphateEbola Infection · 2019-02-28 · Not FDA Approved for Orphan Indication
  • FDA tilorone dihydrochlorideEbola Infection · 2018-02-07 · Not FDA Approved for Orphan Indication
  • FDA RanpirnaseEbola Virus Disease · 2017-07-14 · Not FDA Approved for Orphan Indication
  • FDA aphidicolinEbola Virus Infection · 2016-04-20 · Not FDA Approved for Orphan Indication
  • FDA RemdesivirEbola Virus Disease · 2015-09-18 · Not FDA Approved for Orphan Indication
  • FDA recombinant nematode anticoagulant protein c2 (rNAPc2)Viral Hemorrhagic Fever Ebola Exposure to Ebola virus · 2014-12-08 · Not FDA Approved for Orphan Indication

Sources: FDA OOPD · EMA orphan designations

Open Targets candidates

19

Drugs / clinical candidates · MONDO_0005737

CTD chemicals (MyDisease.info)

7 associated chemicals. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • apilimod · therapeutic
  • BH30sucMan · therapeutic
  • favipiravir · therapeutic
  • galidesivir · therapeutic
  • N-pip-phenylalanine-homophenylalanine-vinyl sulfone phenyl · therapeutic
  • remdesivir · therapeutic
  • Teicoplanin · therapeutic

MyDisease.info · MONDO:0005737

Literature

Is anyone studying this?

66,466

66,466 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

66,466 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

51,639 in the last 10 years · low confidence

Phrase hits: 66,466 · MeSH hits: 175

Open Europe PMC search

Who's working on it?

1,452

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Crozier I6 papers · 2026

    Clinical Monitoring Research Program Directorate, , , ,

    Papers in Europe PMC
  2. 02
    Mbala-Kingebeni P6 papers · 2026

    National Institute for Biomedical Research, Kinshasa, Democratic Republic of Congo.

    Papers in Europe PMC
  3. 03
    Reilly C5 papers · 2026

    Division of Biostatistics and Health Data Science, , , ,

    Papers in Europe PMC
  4. 04
    Zeng X5 papers · 2026

    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, United States of America.

    Papers in Europe PMC
  5. 05
    Ahuka-Mundeke S4 papers · 2026

    Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of Congo.

    Papers in Europe PMC
  6. 06
    Carroll MW4 papers · 2026

    Pandemic Sciences Institute & Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

    Papers in Europe PMC
  7. 07
    Fallah M4 papers · 2026

    , ,

    Papers in Europe PMC
  8. 08
    Fashina T4 papers · 2025

    Ophthalmology and Visual Sciences, University of Nebraska Medical Centre College of Medicine, Omaha, Nebraska, USA.

    Papers in Europe PMC
  9. 09
    Harrison-Williams L4 papers · 2025

    Ministry of Health, Freetown, Sierra Leone.

    Papers in Europe PMC
  10. 10
    Hayek BR4 papers · 2025

    Ophthalmology and Visual Sciences, University of Nebraska Medical Centre College of Medicine, Omaha, Nebraska, USA.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

89

interventional trials for this specific condition

89 interventional trials matched this specific condition name; 5 currently recruiting in our sample. 47 trials are registered for hemorrhagic fever, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 11 September 2026

89 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 98.3th percentile).

low confidence · 98.3th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

89 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: hemorrhagic fever

47

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

16 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 12 · after dedupe 12 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 12 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (12)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Ebola hemorrhagic fever — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Ebola hemorrhagic fever" OR "Ebola fever" OR "Ebola virus disease" OR "Ebola" OR "Ebolavirus infectious disease"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Hemorrhagic Fever, Ebola

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Ebola hemorrhagic fever" OR "Ebola fever" OR "Ebola virus disease" OR "Ebola" OR "Ebolavirus infectious disease" OR "Hemorrhagic Fever, Ebola"

Interventional trials matched via: both, phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 89 interventional · 16 observational · 2 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"hemorrhagic fever"

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: EHF; Ebolavirus caused disease or disorder; Ebolavirus disease or disorder

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (66466) is implausibly high for prevalence class "<1 / 1 000 000" — treat as possible over-matching, not a measure of research intensity

Ingested 2026-07-27T13:19:03.087Z