ORPHA:31826
Ethylene glycol poisoning
Publications
817
82.1th percentile
Trials
0
Interventional, condition-specific
Researchers
934
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A rare poisoning resulting in elevated anion gap , due to the production of glycolic acid, glyoxylic acid, and oxalic acid by alcohol dehydrogenase (ADH) in the liver when ethylene glycol is metabolized, characterized initially by euphoria, slurred speech, , coma and , and followed by late manifestations such as tachycardia, arrhythmias, myocardial depression, hemodynamic imbalance and, finally, acute renal failure.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
817 matched papers (254 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPartial
None under the specific name; 122 for broader category poisoning
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
817
817 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
817 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
254 in the last 10 years · high confidence · 82.1th percentile (publications denominator)
Phrase hits: 817 · MeSH hits: 0
Who's working on it?
934
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Ghannoum M5 papers · 2024
Division of Nephrology, University of Montreal, Verdun Hospital, Montreal, QC, Canada.
Papers in Europe PMC - 02Hovda KE5 papers · 2024
Norwegian National Unit for CBRNE Medicine, Department of Acute Medicine, Oslo University Hospital, Oslo, Norway.
Papers in Europe PMC - 03Daudon M4 papers · 2021
Sorbonne Université, Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche-S 1155, Assistance Publique des Hôpitaux de Paris Service des Explorations Fonctionnelles Multidisciplinaires, Hôpital Tenon, Paris, France.
Papers in Europe PMC - 04Letavernier E4 papers · 2021
Sorbonne Université, Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche-S 1155, Assistance Publique des Hôpitaux de Paris Service des Explorations Fonctionnelles Multidisciplinaires, Hôpital Tenon, Paris, France.
Papers in Europe PMC - 05Ramachandran A4 papers · 2025
Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
Papers in Europe PMC - 06Roberts DM4 papers · 2023
Renal Medicine, The Canberra Hospital, Garran, Australian Capital Territory, Australia; Medical School, Australian National University, Acton, Australian Capital Territory, Australia; New South Wales Poisons Information Centre, Westmead Children's Hospital, Sydney, New South Wales, Australia. Electronic address: 1darren1@gmail.com.
Papers in Europe PMC - 07Akakpo JY3 papers · 2025
Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
Papers in Europe PMC - 08Becker JU3 papers · 2021
Institute of Pathology, University of Cologne, Cologne, Germany.
Papers in Europe PMC - 09Hoffman RS3 papers · 2023
Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Papers in Europe PMC - 10Jaeschke H3 papers · 2024
Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: hjaeschke@kumc.edu.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name. 1 observational study did — shown below because natural-history and cohort work can be an important step toward a trial. 122 trials are registered for poisoning, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
122 interventional trials matched poisoning, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: poisoning
122
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT06811675·RECRUITING·The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning
Conditions: Carbon Monoxide Poisoning · Delayed Neurocognitive Sequelae·Matched via name phrase
- NCT07103356·RECRUITING·Table-Top Water Pitcher to Reduce Arsenic Exposure Among Well Users in New Hampshire
Conditions: Arsenic Poisoning · Environmental Exposure · Water-Related Diseases·Matched via name phrase
- NCT07234383·NOT YET RECRUITING·Accelerated HEmodiafiltration in Severe Acute Diquat (AHEAD) Poisoning
Conditions: Diquat Poisoning·Matched via name phrase
- NCT07201311·RECRUITING·Combined Gastrointestinal Decontamination in Acute Severe Poisoning
Conditions: Severe Poisoning With Cardiotropic or Psychotropic Drug · Admission to Intensive Care·Matched via name phrase
- NCT07459166·RECRUITING·A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade
Conditions: Fentanyl Overdose · Fentanyl Poisoning·Matched via name phrase
- NCT04499885·RECRUITING·Potential Role of Gastric Lavage by Paraffin Oil in Acute Aluminum Phosphide Poisoning
Conditions: Toxicity, Drug·Matched via name phrase
- NCT06574048·NOT YET RECRUITING·Carbon Monoxide Hyperbaric Oxygen With Steroid Therapy
Conditions: Carbon Monoxide Poisoning · Carbon Monoxide Intoxication · Carbon Monoxide Encephalopathy · Carbon Monoxide-induced Parkinsonism·Matched via name phrase
- NCT05471479·RECRUITING·Activated CHARcoal in Poisoned Patient - Pilot Trial
Conditions: Charcoal, Decontamination, Poisoning·Matched via name phrase
- NCT07632937·NOT YET RECRUITING·A Study to Assess the Efficacy of Public Health Campaigns in Reducing Lead Exposure
Conditions: Lead Poisoning · Environmental Exposure·Matched via name phrase
- NCT06966765·NOT YET RECRUITING·Accelerated vs Standard Approach to Continuous Veno-venous Hemodiafiltration Post-hemoperfusion (ASAP) in Severe Acute Diquat Poisoning
Conditions: Diquat Poisoning·Matched via name phrase
Observational and natural-history studies
1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Ethylene glycol poisoning"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Ethylene glycol poisoning"
Study-type breakdown: 0 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"poisoning"
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-26T23:30:11.243Z