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ORPHA:31740

Hypersensitivity pneumonitis

low confidenceDisorder

Also known as: Extrinsic allergic alveolitis

Publications

11,058

Trials

19

Interventional, condition-specific

Researchers

1,244

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

A rare, immunologically mediated, interstitial lung disease characterized by respiratory symptoms (cough, dyspnea) due to sensitization and subsequent hypersensitivity to environmental antigens. The disorder may be accompanied by systemic manifestations (weight loss, fatigue).

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (6)

HP · allergic form of pneumonitis · allergic pneumonitis · exogen allergic alveolitis · extrinsic allergic alveolitis · hypersensitivity pneumonitis

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    11,058 matched papers (6,116 in last 10 years) Source

  3. Phenotype characterisedPresent

    33 HPO annotations (e.g. Hypersensitivity pneumonitis; Increased circulating IgE concentration; Elevated erythrocyte sedimentation rate) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    19 matched on ClinicalTrials.gov (4 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

33

Associated phenotypes · MONDO:0017853

  • Hypersensitivity pneumonitis
  • Increased circulating IgE concentration
  • Elevated erythrocyte sedimentation rate
  • Elevated circulating C-reactive protein concentration

Showing 4 of 33 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

3

Drugs / clinical candidates · MONDO_0017853

CTD chemicals (MyDisease.info)

7 associated chemicals · 10 pathways. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • Air Pollutants · marker/mechanism
  • Amiodarone · marker/mechanism
  • Cocaine · marker/mechanism
  • Ovalbumin · marker/mechanism
  • Particulate Matter · marker/mechanism
  • Pravastatin · marker/mechanism
  • trofosfamide · marker/mechanism

Pathways: FoxO signaling pathway; Peroxisome; Longevity regulating pathway; Longevity regulating pathway - multiple species; Huntington's disease; Disease; Cellular responses to stress; Detoxification of Reactive Oxygen Species

MyDisease.info · MONDO:0017853

Literature

Is anyone studying this?

11,058

11,058 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

11,058 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

6,116 in the last 10 years · low confidence

Phrase hits: 11,058 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,244

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Adegunsoye A10 papers · 2026

    Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, United States.

    Papers in Europe PMC
  2. 02
    Fernández Pérez ER9 papers · 2026

    Division of Pulmonary, Critical Care and Sleep Medicine National Jewish Health Denver, Colorado.

    Papers in Europe PMC
  3. 03
    Lynch DA8 papers · 2026

    Division of Radiology National Jewish Health Denver, Colorado.

    Papers in Europe PMC
  4. 04
    Ogura T8 papers · 2026

    Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-higashi, Kanazawa-ku, Yokohama, 236-0051, Japan.

    Papers in Europe PMC
  5. 05
    Takemura T8 papers · 2026

    Department of Pathology, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-higashi, Kanazawa-ku, Yokohama, 236-0051, Japan.

    Papers in Europe PMC
  6. 06
    Johannson KA7 papers · 2026

    Medicine, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada kerri.johannson@ahs.ca.

    Papers in Europe PMC
  7. 07
    Adams TN6 papers · 2026

    Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.

    Papers in Europe PMC
  8. 08
    Chaudhary S6 papers · 2026

    Respiratory Medicine, Guy's and St Thomas' NHS Foundation Trust, London, England, UK.

    Papers in Europe PMC
  9. 09
    Hagiwara E6 papers · 2026

    Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-higashi, Kanazawa-ku, Yokohama, 236-0051, Japan.

    Papers in Europe PMC
  10. 10
    Moua T6 papers · 2026

    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

19

interventional trials for this specific condition

19 interventional trials matched this specific condition name; 4 currently recruiting in our sample. 56 trials are registered for pneumonitis, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 11 September 2026

19 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 94.6th percentile).

low confidence · 94.6th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

19 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: pneumonitis

56

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

15 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 50 · after dedupe 50 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 50 · dropped 0 · fetched 2026-07-29

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (50)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Hypersensitivity pneumonitis — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Hypersensitivity pneumonitis" OR "Extrinsic allergic alveolitis" OR "allergic form of pneumonitis" OR "allergic form of the pneumonitis" OR "allergic pneumonitis" OR "exogen allergic alveolitis"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Hypersensitivity pneumonitis" OR "Extrinsic allergic alveolitis" OR "allergic form of pneumonitis" OR "allergic form of the pneumonitis" OR "allergic pneumonitis" OR "exogen allergic alveolitis"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 19 interventional · 15 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"pneumonitis"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: HP

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (11058) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-26T23:29:22.358Z