ORPHA:314473
Ovarian fibroma
Publications
1,270
Trials
0
Interventional, condition-specific
Researchers
1,032
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A rare benign ovarian tumor of sex cord / stromal origin characterized by an abdominal mass which may present with abdominal pain, distension, or menorrhagia, among others, or may also be asymptomatic. Association with ascites and hydrothorax is known as Meigs syndrome. The tumor can be solid and/or cystic in nature. Histologically it features bundles of spindle cells forming variable amounts of collagen, without cellular atypia or atypical mitoses.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0008168
- MeSH:C562391
- OMIM:166970
- UMLS:C0149951
- NCIT:C3498
Additional Mondo synonyms (4)
fibroma of ovary · fibroma of the ovary · ovarian fibroma · ovarian fibroma (disease)
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
1,270 matched papers (519 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPartial
None under the specific name; 4 for broader category fibroma
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
1,270
1,270 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
1,270 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
519 in the last 10 years · low confidence
Phrase hits: 1,270 · MeSH hits: 1
Who's working on it?
1,032
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Zhang J5 papers · 2026
Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Papers in Europe PMC - 02Zhang Y5 papers · 2025
Department of Dermatology, First Hospital of Shanxi Medical University, Taiyuan, China.
Papers in Europe PMC - 03Li J3 papers · 2024
Department-1 of Gynecological Oncology Jilin Cancer Hospital Jilin China.
Papers in Europe PMC - 04Liu X3 papers · 2026
Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Papers in Europe PMC - 05Singh S3 papers · 2025
Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Papers in Europe PMC - 06Thanasa A3 papers · 2025
Department of Anatomy, Department of Health Sciences, Medical School, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Papers in Europe PMC - 07Thanasa E3 papers · 2025
Department of Histology, Department of Health Sciences, Medical School, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Papers in Europe PMC - 08Thanasas I3 papers · 2025
Department of Obstetrics and Gynecology, General Hospital of Trikala, Trikala, GRC.
Papers in Europe PMC - 09Wang J3 papers · 2026
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.
Papers in Europe PMC - 10Wang Y3 papers · 2026
Department of PET/CT, Qingdao Central Hospital, No 127. SiLiu Nan Street, ShanDong Province, Qingdao City, 266042, China. wangyanli1105@163.com.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present). 4 trials are registered for fibroma, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
low confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
4 interventional trials matched fibroma, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: fibroma
4
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT05440240·RECRUITING·Percutaneous Needle Fasciotomy +/- Corticosteroid Injection for Dupuytren's Contracture
Conditions: Dupuytren Contracture · Dupuytren's Disease · Contracture · Joint Diseases·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Ovarian fibroma" OR "fibroma of ovary" OR "fibroma of the ovary" OR "ovarian fibroma (disease)"
MeSH descriptor terms unioned into the query: Ovarian Fibromata
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Ovarian fibroma" OR "fibroma of ovary" OR "fibroma of the ovary" OR "ovarian fibroma (disease)" OR "Ovarian Fibromata" OR "ovarian benign neoplasm"
Recall-expansion terms: ovarian benign neoplasm
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"fibroma"
Query health: ok — strategies attempted: phrase, mesh, recall-expansion; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (1270) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-27T13:08:08.113Z