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ORPHA:314022

Gastric adenocarcinoma and proximal polyposis of the stomach

low confidenceDisorder

Also known as: Familial fundic gland polyposis with gastric cancer · GAPPS

Query health: suspect — Only one of 2 strategies returned hits (phrase).

Publications

1,179

Trials

0

Interventional, condition-specific

Researchers

1,353

Distinct authors in sample

Gene link

APC

Definitive

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is a rare gastric cancer characterized by proximal gastric polyposis and increased risk of early-onset, intestinal-type adenocarcinoma of the gastric body, with no duodenal or colorectal polyposis.

How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (6)

APC-related gastric adenocarcinoma and proximal polyposis of the stomach · familial fundic gland polyposis with gastric cancer · fundic gland polyposis · polyposis of gastric fundus without polyposis coli · polyposis, gastric · polyposis, gastric, Dos Santos and de Magalhaes 1980

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.

  1. Gene identifiedPresent

    Definitive — APC

  2. LiteraturePresent

    1,179 matched papers (760 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPartial

    None under the specific name; 132 for broader category polyposis

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Yes — we know a specific gene responsible (APC).

GenCC classification: Definitive.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

1,179

1,179 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

1,179 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

760 in the last 10 years · low confidence

Phrase hits: 1,179 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,353

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.

  1. 01
    Carneiro F9 papers · 2024

    Departments of Pathology, Centro Hospitalar São João/Faculty of Medicine of Porto University and Institute for Research and Innovation in Health/Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal.

    Papers in Europe PMC
  2. 02
    Bush NR7 papers · 2026

    Department of Psychiatry and Behavioral Sciences, University of California at San Francisco School of Medicine, San Francisco, California, United States of America.

    Papers in Europe PMC
  3. 03
    LeWinn KZ7 papers · 2026

    Department of Psychiatry and Behavioral Sciences, University of California, San Francisco.

    Papers in Europe PMC
  4. 04
    Sathyanarayana S7 papers · 2025

    Department of Environmental & Occupational Health Sciences, School of Public Health, University of Washington, Seattle, Washington, United States of America.

    Papers in Europe PMC
  5. 05
    Baba H6 papers · 2026

    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. hdobaba@kumamoto-u.ac.jp.

    Papers in Europe PMC
  6. 06
    Iwatsuki M6 papers · 2026

    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

    Papers in Europe PMC
  7. 07
    Karr CJ6 papers · 2026

    Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle.

    Papers in Europe PMC
  8. 08
    Aelvoet AS5 papers · 2026

    Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Amsterdam, The Netherlands.

    Papers in Europe PMC
  9. 09
    Dekker E5 papers · 2026

    Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Amsterdam, The Netherlands. e.dekker@amsterdamumc.nl.

    Papers in Europe PMC
  10. 10
    Karstensen JG5 papers · 2026

    Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

0

interventional trials for this specific condition

No interventional trial testing a treatment matched this specific condition name. 1 observational study did — shown below because natural-history and cohort work can be an important step toward a trial. 132 trials are registered for polyposis, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.

low confidence · 36.5th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.

132 interventional trials matched polyposis, the broader category — listed below. Those studies are not counted in the condition-specific total.

Broader category: polyposis

132

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

None of the matched observational studies is currently listed as recruiting.

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Gastric adenocarcinoma and proximal polyposis of the stomach" OR "Gastric adenocarcinoma and proximal polyposis of stomach" OR "Familial fundic gland polyposis with gastric cancer" OR "GAPPS" OR "APC-related gastric adenocarcinoma and proximal polyposis of the stomach" OR "APC-related gastric adenocarcinoma and proximal polyposis of stomach" OR "fundic gland polyposis" OR "polyposis of gastric fundus without polyposis coli" OR "polyposis of the gastric fundus without polyposis coli" OR "polyposis, gastric" OR "polyposis, gastric, Dos Santos and de Magalhaes 1980"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Polyposis Of Gastric Fundus Without Polyposis Coli

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Gastric adenocarcinoma and proximal polyposis of the stomach" OR "Gastric adenocarcinoma and proximal polyposis of stomach" OR "Familial fundic gland polyposis with gastric cancer" OR "GAPPS" OR "APC-related gastric adenocarcinoma and proximal polyposis of the stomach" OR "APC-related gastric adenocarcinoma and proximal polyposis of stomach" OR "fundic gland polyposis" OR "polyposis of gastric fundus without polyposis coli" OR "polyposis of the gastric fundus without polyposis coli" OR "polyposis, gastric" OR "polyposis, gastric, Dos Santos and de Magalhaes 1980"

Study-type breakdown: 0 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"polyposis"

Query health: suspect — strategies attempted: phrase, mesh; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (1179) is implausibly high for prevalence class "<1 / 1 000 000" — treat as possible over-matching, not a measure of research intensity

Ingested 2026-07-27T13:02:44.350Z