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ORPHA:3099

Rheumatic fever

low confidenceDisorder

Also known as: Acute rheumatic fever

Publications

39,489

Trials

8

Interventional, condition-specific

Researchers

1,132

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (2)

ARF · acute rheumatic fever

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    39,489 matched papers (9,593 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    8 matched on ClinicalTrials.gov (3 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

39,489

39,489 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

39,489 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

9,593 in the last 10 years · low confidence

Phrase hits: 39,489 · MeSH hits: 662

Open Europe PMC search

Who's working on it?

1,132

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Carapetis J12 papers · 2026

    Strep A Translation, The Kids Research Institute Australia, University of Western Australia, Perth, Australia; Perth Children's Hospital, 15 Hospital Ave, Nedlands, Western Australia, Australia.

    Papers in Europe PMC
  2. 02
    Beaton A10 papers · 2026

    Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

    Papers in Europe PMC
  3. 03
    Bennett J10 papers · 2026

    Department of Public Health, University of Otago, Wellington, New Zealand.

    Papers in Europe PMC
  4. 04
    Moreland NJ10 papers · 2026

    Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.

    Papers in Europe PMC
  5. 05
    Marangou J8 papers · 2026

    Menzies School of Health Research, Charles Darwin University, Darwin, Australia; Royal Perth Hospital, Perth, Australia. Electronic address: james.marangou@menzies.edu.au.

    Papers in Europe PMC
  6. 06
    Baker MG7 papers · 2026

    Department of Public Health, University of Otago, Wellington, New Zealand.

    Papers in Europe PMC
  7. 07
    Francis JR7 papers · 2026

    Department of Paediatrics, Royal Darwin Hospital, Darwin, Australia.

    Papers in Europe PMC
  8. 08
    Remenyi B7 papers · 2026

    Department of Paediatrics, Royal Darwin Hospital, Darwin, Australia.

    Papers in Europe PMC
  9. 09
    Rwebembera J7 papers · 2026

    Uganda Heart Institute, Kampala, Uganda.

    Papers in Europe PMC
  10. 10
    Webb R7 papers · 2026

    Department of Paediatrics, Child and Youth Health, The University of Auckland, Auckland, New Zealand.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

8

interventional trials for this specific condition

8 interventional trials matched this specific condition name; 3 currently recruiting in our sample.

Data as of 27 July 2026

8 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 90.6th percentile).

low confidence · 90.6th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

8 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

6 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

None of the matched observational studies is currently listed as recruiting.

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Rheumatic fever" OR "Acute rheumatic fever"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Rheumatic Fever

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Rheumatic fever" OR "Acute rheumatic fever"

Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 8 interventional · 6 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: ARF

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (39489) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-26T22:13:36.314Z