ORPHA:306644
Complication after organ transplantation
Publications
70
40.3th percentile
Trials
0
Interventional, condition-specific
Researchers
509
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
How rare: 1-9 / 100 000 — about one to nine people per hundred thousand.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0700220
- UMLS:C1998172
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
70 matched papers (29 in last 10 years) Source
- Phenotype characterisedPresent
133 HPO annotations (e.g. Fever; Lymphadenopathy; Fatigue) Source
- Animal modelNot found
No Alliance genotype “model of” associations via Monarch for these Mondo IDs
- Orphan designationNot found
No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
133
Associated phenotypes · MONDO:0700220
- Fever
- Lymphadenopathy
- Fatigue
- Malaise
- Abnormality of the voice
Showing 5 of 133 — open Monarch for the full list.
Animal models (Monarch / Alliance)
None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.
Monarch fetch 2026-07-29
Therapies
Designations, candidates, and chemicals
FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.
Orphan designation (FDA · EMA)
No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.
Open Targets candidates
No drugs or clinical candidates returned for this Mondo ID on Open Targets.
CTD chemicals (MyDisease.info)
No CTD chemical associations returned for this Mondo ID.
Literature
Is anyone studying this?
70
70 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.
70 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).
29 in the last 10 years · high confidence · 40.3th percentile (publications denominator)
Phrase hits: 70 · MeSH hits: 0
Who's working on it?
509
Distinct author names in 70 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Domanski L2 papers · 2015
Clinical Department of Nephrology, Transplantology & Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
Papers in Europe PMC - 02Dziedziejko V2 papers · 2015
Department of Biochemistry & Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
Papers in Europe PMC - 03Furukawa H2 papers · 2005Papers in Europe PMC
- 04
- 05Luo Z2 papers · 2025
Division of kidney Transplantation, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 2nd road Zhongshan, Yuexiu District, Guangzhou, 510080, China.
Papers in Europe PMC - 06Pace Napoleone C2 papers · 2021
Pediatric Cardiac Surgery and Congenital Cardiopathies Unit, Regina Margherita Children's Hospital, Azienda Ospedaliera Città Della Salute E Della Scienza Di Torino, Turin, Italy.
Papers in Europe PMC - 07Pawlik A2 papers · 2015
Department of Physiology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland.
Papers in Europe PMC - 08Romanowski M2 papers · 2015
Department of General & Transplantation Surgery, Pomeranian Medical University, Szczecin, Poland.
Papers in Europe PMC - 09Safranow K2 papers · 2015
Department of Biochemistry & Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
Papers in Europe PMC - 10Sanchez-Gurmaches J2 papers · 2016
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 11 September 2026 · last trial check 11 September 2026
No matched interventional trials. This is true for 77.2% of diseases in the trials denominator (5501 of 7126). Here are the researchers publishing on it.
high confidence · 38.6th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Other registries (secondary)
Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.
raw 17 · after dedupe 17 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 17 · dropped 0 · fetched 2026-07-30
Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri
No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).
Uncertain / not reviewed (17)
- isrctn·ISRCTN15444108·No longer recruiting·The study investigates how machine preservation methods protect and repair donor livers, and aims to understand which methods work best and why, so more of these higher-risk livers can be safely used for transplants
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN73484674·Recruiting·Reducing blood clots in donated livers before transplantation
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN12632431·Recruiting·A Phase III placebo-controlled efficacy and safety study of mocravimod as an adjunctive and maintenance treatment in acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplantation
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN27200385·No longer recruiting·A study to assess the safety and distribution of GDC-8264 in combination with standard of care corticosteroid treatment in the blood of participants with high-risk acute graft-versus-host disease (aGVHD)
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN13476586·No longer recruiting·Home-based exercise and motivational programme before and after liver transplantation: ExaLT Trial
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN12014920·No longer recruiting·Study drug ELX-02 for patients with Alport syndrome
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN83842641·Recruiting·A trial assessing preoperative chemotherapy in patients with locally advanced but operable colon cancer
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN50290131·No longer recruiting·Comparing interventions for the prevention of graft-versus-host disease after unrelated donor stem cell transplantation
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN54006056·No longer recruiting·A point of care test to aid in diagnosis of suspected sepsis and optimal use of antibiotics in adults presenting to A & E
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN11814003·No longer recruiting·Trial of faecal microbiota transplantation in cirrhosis
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN15527114·No longer recruiting·HOPE for human livers
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN97547683·No longer recruiting·Treg Immunotherapy in Crohn’s Disease
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN10329248·No longer recruiting·Optimising the cardiovascular system following liver transplantation surgery
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN12622749·No longer recruiting·Evaluation of iloprost in the postoperative period after liver transplantation
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN89667087·No longer recruiting·A study of a new technique for organ preservation
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN23557269·No longer recruiting·A randomised controlled trial of patient-specific oxygen monitoring to reduce blood transfusion during heart surgery
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN74928896·No longer recruiting·CytoMegaloVirus~IMmunoProphylactic Adoptive Cellular Therapy study
skipped — LLM skipped (--skip-llm)
Where to find support
Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.
Orphanet entry for Complication after organ transplantation — check Associations / patient organisations on that page.
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Complication after organ transplantation"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Complication after organ transplantation"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T12:48:38.428Z