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ORPHA:3002

Immune thrombocytopenia

medium confidenceDisorder

Also known as: ITP · Immune thrombocytopenic purpura

Publications

30,973

99.1th percentile

Trials

386

Interventional, condition-specific

Researchers

1,138

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare autoimmune coagulation disorder characterized by isolated thrombocytopenia (a platelet count <100,000/microL), in the absence of any underlying disorder that may be associated with thrombocytopenia.

How rare: 1-5 / 10 000 — about one to five people per ten thousand (still uncommon, but less ultra-rare).

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (5)

autoimmune thrombocytopenic purpura · idiopathic thrombocytopenia · idiopathic thrombocytopenia purpura · idiopathic thrombocytopenic purpura · thrombocytopenic purpura, autoimmune

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    30,973 matched papers (17,257 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    386 matched on ClinicalTrials.gov (110 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

30,973

30,973 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

30,973 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

17,257 in the last 10 years · medium confidence · 99.1th percentile (publications denominator)

Phrase hits: 30,973 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,138

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Li Y4 papers · 2026

    Hebei Key Laboratory of Hematology, Department of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

    Papers in Europe PMC
  2. 02
    Saki N3 papers · 2026

    Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

    Papers in Europe PMC
  3. 03
    Wang Z3 papers · 2026

    Songjiang District Sijing Hospital, Shanghai, 201600, China.

    Papers in Europe PMC
  4. 04
    Zhang X3 papers · 2026

    School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China; (J.D.); (Y.Z.)

    Papers in Europe PMC
  5. 05
    AbuBaha M2 papers · 2025

    Department of Medicine An-Najah National University Nablus Palestine.

    Papers in Europe PMC
  6. 06
    Aljunaidi R2 papers · 2025

    Faculty of Medicine and Health Sciences Palestine Polytechnic University Hebron Palestine.

    Papers in Europe PMC
  7. 07
    Almasalma M2 papers · 2026

    Faculty of Medicine, Mansoura University, Mansoura, Egypt.

    Papers in Europe PMC
  8. 08
    Alqadi M2 papers · 2025

    Department of Medicine University of Toledo Toledo Ohio USA.

    Papers in Europe PMC
  9. 09
    Amin MK2 papers · 2025

    Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA; Mikael Rayaan Foundation Global Transplantation and Cellular Therapy Consortium, Kansas City, KS, USA.

    Papers in Europe PMC
  10. 10
    Baniowda M2 papers · 2025

    Department of Medicine University of Missouri-Kansas City Kansas City Missouri USA.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

386

interventional trials for this specific condition

386 interventional trials matched this specific condition name; 110 currently recruiting in our sample. 319 trials are registered for thrombocytopenia, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

386 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 99.6th percentile).

medium confidence · 99.6th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

386 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: thrombocytopenia

319

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

105 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Immune thrombocytopenia" OR "Immune thrombocytopenic purpura" OR "autoimmune thrombocytopenic purpura" OR "idiopathic thrombocytopenia" OR "idiopathic thrombocytopenia purpura" OR "idiopathic thrombocytopenic purpura" OR "thrombocytopenic purpura, autoimmune"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Immune thrombocytopenia" OR "Immune thrombocytopenic purpura" OR "autoimmune thrombocytopenic purpura" OR "idiopathic thrombocytopenia" OR "idiopathic thrombocytopenia purpura" OR "idiopathic thrombocytopenic purpura" OR "thrombocytopenic purpura, autoimmune"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 386 interventional · 105 observational · 2 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"thrombocytopenia"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: ITP

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-26T21:58:04.493Z