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ORPHA:2965

Prolactinoma

medium confidenceDisorder

Also known as: Lactotroph adenoma · PRL-secreting pituitary adenoma · PRLoma · Pituitary lactotrophic adenoma · Prolactin-secreting pituitary adenoma

Publications

10,146

97.4th percentile

Trials

14

Interventional, condition-specific

Researchers

1,116

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare, usually benign, neoplasm of the anterior pituitary gland that results in hyperprolactinemia. The most common clinical manifestations are amenorrhea and infertility in women; and impotence, decreased libido and infertility in men.

How rare: 1-5 / 10 000 — about one to five people per ten thousand (still uncommon, but less ultra-rare).

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (27)

PRL producing pituitary gland adenoma · lactotrope adenoma · lactotroph adenoma · lactotroph cell adenoma · pituitary gland prolactinoma · pituitary lactotrophic adenoma · pituitary prolactinoma · prolactin producing adenoma of pituitary · prolactin producing adenoma of pituitary gland · prolactin producing adenoma of the pituitary · prolactin producing adenoma of the pituitary gland · prolactin producing pituitary adenoma · prolactin producing pituitary gland adenoma · prolactin secreting adenoma · prolactin secreting adenoma of pituitary · prolactin secreting adenoma of pituitary gland · prolactin secreting adenoma of the pituitary · prolactin secreting adenoma of the pituitary gland · prolactin secreting pituitary adenoma · prolactin secreting pituitary gland adenoma · prolactin-producing pituitary gland adenoma · prolactin-secreting pituitary adenoma · prolactinoma · prolactinoma of pituitary · prolactinoma of pituitary gland · prolactinoma of the pituitary · prolactinoma of the pituitary gland

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    10,146 matched papers (4,624 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    14 matched on ClinicalTrials.gov (4 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

10,146

10,146 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

10,146 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

4,624 in the last 10 years · medium confidence · 97.4th percentile (publications denominator)

Phrase hits: 10,146 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,116

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Wang Y6 papers · 2026

    Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.

    Papers in Europe PMC
  2. 02
    Zhang Y5 papers · 2026

    Department of Endocrinology, Chongqing General Hospital, Chongqing, China.

    Papers in Europe PMC
  3. 03
    Andereggen L4 papers · 2026

    Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland. lukas.andereggen@unibe.ch.

    Papers in Europe PMC
  4. 04
    Christ E4 papers · 2026

    Department of Endocrinology, Diabetes and Metabolism, University Hospital of Basel, Basel, Switzerland.

    Papers in Europe PMC
  5. 05
    Huang Y4 papers · 2026

    Sino-German Neuro-Oncology Molecular Laboratory, Department of Neurosurgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan 430030, China.

    Papers in Europe PMC
  6. 06
    Li S4 papers · 2026

    Sino-German Neuro-Oncology Molecular Laboratory, Department of Neurosurgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan 430030, China.

    Papers in Europe PMC
  7. 07
    Wang L4 papers · 2026

    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, USA.

    Papers in Europe PMC
  8. 08
    Wang Z4 papers · 2026

    Sino-German Neuro-Oncology Molecular Laboratory, Department of Neurosurgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan 430030, China.

    Papers in Europe PMC
  9. 09
    Zhang J4 papers · 2026

    Paediatric Department, Shaoxing Women and Children's Hospital, Shaoxing, China.

    Papers in Europe PMC
  10. 10
    Bianchi A3 papers · 2026

    UOC di Endocrinologia e Diabetologia, Fondazione Policlinico Universitario A. Gemelli, IRCCS, ENETS Center of Excellence, Istituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, Rome, Italy.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

14

interventional trials for this specific condition

14 interventional trials matched this specific condition name; 4 currently recruiting in our sample.

Data as of 27 July 2026

14 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 93.1th percentile).

medium confidence · 93.1th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

14 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

8 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Prolactinoma" OR "Lactotroph adenoma" OR "PRL-secreting pituitary adenoma" OR "PRLoma" OR "Pituitary lactotrophic adenoma" OR "Prolactin-secreting pituitary adenoma" OR "PRL producing pituitary gland adenoma" OR "lactotrope adenoma" OR "lactotroph cell adenoma" OR "pituitary gland prolactinoma" OR "pituitary prolactinoma" OR "prolactin producing adenoma of pituitary" OR "prolactin producing adenoma of the pituitary" OR "prolactin producing adenoma of pituitary gland" OR "prolactin producing adenoma of the pituitary gland" OR "prolactin producing pituitary adenoma" OR "prolactin producing pituitary gland adenoma" OR "prolactin secreting adenoma" OR "prolactin secreting adenoma of pituitary" OR "prolactin secreting adenoma of the pituitary" OR "prolactin secreting adenoma of pituitary gland" OR "prolactin secreting adenoma of the pituitary gland" OR "prolactin secreting pituitary adenoma" OR "prolactin secreting pituitary gland adenoma" OR "prolactin-producing pituitary gland adenoma" OR "prolactinoma of pituitary" OR "prolactinoma of the pituitary" OR "prolactinoma of pituitary gland" OR "prolactinoma of the pituitary gland"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Prolactinoma" OR "Lactotroph adenoma" OR "PRL-secreting pituitary adenoma" OR "PRLoma" OR "Pituitary lactotrophic adenoma" OR "Prolactin-secreting pituitary adenoma" OR "PRL producing pituitary gland adenoma" OR "lactotrope adenoma" OR "lactotroph cell adenoma" OR "pituitary gland prolactinoma" OR "pituitary prolactinoma" OR "prolactin producing adenoma of pituitary" OR "prolactin producing adenoma of the pituitary" OR "prolactin producing adenoma of pituitary gland" OR "prolactin producing adenoma of the pituitary gland" OR "prolactin producing pituitary adenoma" OR "prolactin producing pituitary gland adenoma" OR "prolactin secreting adenoma" OR "prolactin secreting adenoma of pituitary" OR "prolactin secreting adenoma of the pituitary" OR "prolactin secreting adenoma of pituitary gland" OR "prolactin secreting adenoma of the pituitary gland" OR "prolactin secreting pituitary adenoma" OR "prolactin secreting pituitary gland adenoma" OR "prolactin-producing pituitary gland adenoma" OR "prolactinoma of pituitary" OR "prolactinoma of the pituitary" OR "prolactinoma of pituitary gland" OR "prolactinoma of the pituitary gland"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 14 interventional · 8 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is short or not clearly distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-26T21:49:31.916Z