ORPHA:2965
Prolactinoma
Also known as: Lactotroph adenoma · PRL-secreting pituitary adenoma · PRLoma · Pituitary lactotrophic adenoma · Prolactin-secreting pituitary adenoma
Publications
10,146
94.3th percentile
Trials
14
Interventional, condition-specific
Researchers
1,116
Distinct authors in sample
Gene link
—
Readiness
4/6
Stages with a signal
Clinical definition (Orphanet)
A rare, usually benign, neoplasm of the anterior pituitary gland that results in hyperprolactinemia. The most common clinical manifestations are amenorrhea and infertility in women; and impotence, decreased libido and infertility in men.
How rare: 1-5 / 10 000 — about one to five people per ten thousand (still uncommon, but less ultra-rare).
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0010911
- MeSH:D015175
- OMIM:600634
- UMLS:C0033375
- NCIT:C3342
Additional Mondo synonyms (27)
PRL producing pituitary gland adenoma · lactotrope adenoma · lactotroph adenoma · lactotroph cell adenoma · pituitary gland prolactinoma · pituitary lactotrophic adenoma · pituitary prolactinoma · prolactin producing adenoma of pituitary · prolactin producing adenoma of pituitary gland · prolactin producing adenoma of the pituitary · prolactin producing adenoma of the pituitary gland · prolactin producing pituitary adenoma · prolactin producing pituitary gland adenoma · prolactin secreting adenoma · prolactin secreting adenoma of pituitary · prolactin secreting adenoma of pituitary gland · prolactin secreting adenoma of the pituitary · prolactin secreting adenoma of the pituitary gland · prolactin secreting pituitary adenoma · prolactin secreting pituitary gland adenoma · prolactin-producing pituitary gland adenoma · prolactin-secreting pituitary adenoma · prolactinoma · prolactinoma of pituitary · prolactinoma of pituitary gland · prolactinoma of the pituitary · prolactinoma of the pituitary gland
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
4/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
10,146 matched papers (4,624 in last 10 years) Source
- Phenotype characterisedPresent
50 HPO annotations (e.g. Male hypogonadism; Hypogonadotropic hypogonadism; Female hypogonadism) Source
- Animal modelPresent
2 genotype models (Mus musculus) Source
- Orphan designationNot found
No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source
- Interventional trialPresent
14 matched on ClinicalTrials.gov (4 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
50
Associated phenotypes · MONDO:0010911
- Male hypogonadism
- Hypogonadotropic hypogonadism
- Female hypogonadism
- Hypogonadism
- Abnormality of the menstrual cycle
Showing 5 of 50 — open Monarch for the full list.
Animal models (Monarch / Alliance)
2
Model associations linked to this Mondo ID
- Men1tm1Zqw/Men1+ [background:] involves: 129/Sv * 129P2/OlaHsd·MGI:5009321·Mus musculus
- Tg(Prl-EGFR)#Sme/0 [background:] Not Specified·MGI:5696742·Mus musculus
Monarch fetch 2026-07-29
Therapies
Designations, candidates, and chemicals
FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.
Orphan designation (FDA · EMA)
No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.
Open Targets candidates
9
Drugs / clinical candidates · MONDO_0010911
- LAPATINIB·phase 2
- CURCUMIN·phase 1
- BROMOCRIPTINE·unknown
- CABERGOLINE·phase 2 3
- CHLOROQUINE·unknown
- DOPAMINE·unknown
- HYDROXYCHLOROQUINE·unknown
- PASIREOTIDE·phase 2 3
- ROPINIROLE·phase 1 2
CTD chemicals (MyDisease.info)
21 associated chemicals · 26 pathways. Therapeutic evidence is listed first when present — not a treatment recommendation.
- BAM 1120 · therapeutic
- Bromocriptine · therapeutic
- Cabergoline · therapeutic
- Melatonin · therapeutic
- mesulergine · therapeutic
- Octreotide · therapeutic
- Pergolide · therapeutic
- Resveratrol · therapeutic
- acetoxyestrone · marker/mechanism
- bisphenol A · marker/mechanism
- Cyproterone Acetate · marker/mechanism
- Diethylstilbestrol · marker/mechanism
Pathways: Cytokine-cytokine receptor interaction; Neuroactive ligand-receptor interaction; PI3K-Akt signaling pathway; TGF-beta signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Jak-STAT signaling pathway; Prolactin signaling pathway
Literature
Is anyone studying this?
10,146
10,146 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.
10,146 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).
4,624 in the last 10 years · medium confidence · 94.3th percentile (publications denominator)
Phrase hits: 10,146 · MeSH hits: 0
Who's working on it?
1,116
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Wang Y6 papers · 2026
Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Papers in Europe PMC - 02Zhang Y5 papers · 2026
Department of Endocrinology, Chongqing General Hospital, Chongqing, China.
Papers in Europe PMC - 03Andereggen L4 papers · 2026
Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland. lukas.andereggen@unibe.ch.
Papers in Europe PMC - 04Christ E4 papers · 2026
Department of Endocrinology, Diabetes and Metabolism, University Hospital of Basel, Basel, Switzerland.
Papers in Europe PMC - 05Huang Y4 papers · 2026
Sino-German Neuro-Oncology Molecular Laboratory, Department of Neurosurgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan 430030, China.
Papers in Europe PMC - 06Li S4 papers · 2026
Sino-German Neuro-Oncology Molecular Laboratory, Department of Neurosurgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan 430030, China.
Papers in Europe PMC - 07Wang L4 papers · 2026
Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, USA.
Papers in Europe PMC - 08Wang Z4 papers · 2026
Sino-German Neuro-Oncology Molecular Laboratory, Department of Neurosurgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan 430030, China.
Papers in Europe PMC - 09Zhang J4 papers · 2026
Paediatric Department, Shaoxing Women and Children's Hospital, Shaoxing, China.
Papers in Europe PMC - 10Bianchi A3 papers · 2026
UOC di Endocrinologia e Diabetologia, Fondazione Policlinico Universitario A. Gemelli, IRCCS, ENETS Center of Excellence, Istituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, Rome, Italy.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
14
interventional trials for this specific condition
14 interventional trials matched this specific condition name; 4 currently recruiting in our sample.
Data as of 11 September 2026
14 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 93.7th percentile).
medium confidence · 93.7th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
14 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT06295952·RECRUITING·A Study of Pasireotide in People With Prolactinoma
Not reviewed·Conditions: Prolactin-Producing Pituitary Tumor·Matched via name phrase
- NCT07463235·RECRUITING·Safety and Potency of a High Cabergoline Dosage in Microprolactinomas
Not reviewed·Conditions: Prolactinoma · Prolactin Excess·Matched via name phrase
- NCT06556186·NOT YET RECRUITING·Surgical and Pharmacological Efficacy of Knosp Grade 0-2 Prolactinoma
Not reviewed·Conditions: Pituitary Tumor·Matched via name phrase
- NCT07045935·RECRUITING·Metabolic Outcomes in Patients With Prolactinomas Under Dopamine Agonist Treatment
Not reviewed·Conditions: Prolactinoma·Matched via name phrase
Observational and natural-history studies
8 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT00001595·RECRUITING·An Investigation of Pituitary Tumors and Related Hypothalmic Disorders
Not reviewed·Conditions: Panhypopituitarism · Gigantism/Acromegaly · Prolactinoma · Cushing Disease·Matched via name phrase
- NCT07268183·RECRUITING·How Estrogen Fluctuations Before Diagnosis Affect the Size Prolactin-secreting Tumors
Not reviewed·Conditions: Prolactinoma · Macroprolactinoma·Matched via name phrase
Other registries (secondary)
Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.
raw 3 · after dedupe 3 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 3 · dropped 0 · fetched 2026-07-29
Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri
No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).
Uncertain / not reviewed (3)
- ctis·2025-523829-17-00·Authorised·18F-fluoro-ethyl-tyrosine (18FET) PET for difficult clinical situations in functional pituitary adenoma. A prospective, single arm, single center study. (FET-PIT)
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN90897064·No longer recruiting·Dopamine and memory consolidation
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN41929673·No longer recruiting·Efficacy and safety of orally inhaled apomorphine in patients with Parkinson's disease
skipped — LLM skipped (--skip-llm)
Where to find support
Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.
Orphanet entry for Prolactinoma — check Associations / patient organisations on that page.
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Prolactinoma" OR "Lactotroph adenoma" OR "PRL-secreting pituitary adenoma" OR "PRLoma" OR "Pituitary lactotrophic adenoma" OR "Prolactin-secreting pituitary adenoma" OR "PRL producing pituitary gland adenoma" OR "lactotrope adenoma" OR "lactotroph cell adenoma" OR "pituitary gland prolactinoma" OR "pituitary prolactinoma" OR "prolactin producing adenoma of pituitary" OR "prolactin producing adenoma of the pituitary" OR "prolactin producing adenoma of pituitary gland" OR "prolactin producing adenoma of the pituitary gland" OR "prolactin producing pituitary adenoma" OR "prolactin producing pituitary gland adenoma" OR "prolactin secreting adenoma" OR "prolactin secreting adenoma of pituitary" OR "prolactin secreting adenoma of the pituitary" OR "prolactin secreting adenoma of pituitary gland" OR "prolactin secreting adenoma of the pituitary gland" OR "prolactin secreting pituitary adenoma" OR "prolactin secreting pituitary gland adenoma" OR "prolactin-producing pituitary gland adenoma" OR "prolactinoma of pituitary" OR "prolactinoma of the pituitary" OR "prolactinoma of pituitary gland" OR "prolactinoma of the pituitary gland"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Prolactinoma" OR "Lactotroph adenoma" OR "PRL-secreting pituitary adenoma" OR "PRLoma" OR "Pituitary lactotrophic adenoma" OR "Prolactin-secreting pituitary adenoma" OR "PRL producing pituitary gland adenoma" OR "lactotrope adenoma" OR "lactotroph cell adenoma" OR "pituitary gland prolactinoma" OR "pituitary prolactinoma" OR "prolactin producing adenoma of pituitary" OR "prolactin producing adenoma of the pituitary" OR "prolactin producing adenoma of pituitary gland" OR "prolactin producing adenoma of the pituitary gland" OR "prolactin producing pituitary adenoma" OR "prolactin producing pituitary gland adenoma" OR "prolactin secreting adenoma" OR "prolactin secreting adenoma of pituitary" OR "prolactin secreting adenoma of the pituitary" OR "prolactin secreting adenoma of pituitary gland" OR "prolactin secreting adenoma of the pituitary gland" OR "prolactin secreting pituitary adenoma" OR "prolactin secreting pituitary gland adenoma" OR "prolactin-producing pituitary gland adenoma" OR "prolactinoma of pituitary" OR "prolactinoma of the pituitary" OR "prolactinoma of pituitary gland" OR "prolactinoma of the pituitary gland"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 14 interventional · 8 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is short or not clearly distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-26T21:49:31.916Z