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ORPHA:293208

Celiac artery compression syndrome

low confidenceDisorder

Also known as: Dunbar syndrome · MALS · Median arcuate ligament syndrome

Query health: suspect — Only one of 2 strategies returned hits (phrase).

Publications

1,101

Trials

1

Interventional, condition-specific

Researchers

1,002

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

A rare disease caused by compression of the celiac axis by an abnormally shaped arcuate ligament (the part of the diaphragm in which both pillars join in the midline around the aorta). Patients have recurrent abdominal pain, anorexia and weight loss. The pain is epigastric, and diarrhea or constipation may be present as well. Onset of pain will usually, although not always, be after food intake, and may be associated with nausea and emesis. Other symptoms may include lassitude, exercise intolerance and vomiting. Occasionally, a patient may show an abdominal murmur upon auscultation.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (7)

Median Arcuate Ligament Syndrome · celiac artery compression syndrome · celiac artery stenosis from compression by median arcuate ligament of diaphragm · coeliac artery compression syndrome · median arcuate ligament syndrome · median arcuate ligament syndromic disease · syndromic disease of median arcuate ligament

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    1,101 matched papers (807 in last 10 years) Source

  3. Phenotype characterisedPresent

    2 HPO annotations (e.g. Celiac artery compression; Abdominal pain) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    1 matched on ClinicalTrials.gov (1 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

2

Associated phenotypes · MONDO:0017388

  • Celiac artery compression
  • Abdominal pain

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

1,101

1,101 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

1,101 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

807 in the last 10 years · low confidence

Phrase hits: 1,101 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,002

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Abe T4 papers · 2026

    Department of Gastroenterological Surgery, National Hospital Organization (NHO), Higashihiroshima Medical Center, Higashihiroshima, Hiroshima, Japan.

    Papers in Europe PMC
  2. 02
    Alsabbagh Y3 papers · 2026

    Division of Vascular and Endovascular Surgery, Mayo Clinic, Jacksonville, FL.

    Papers in Europe PMC
  3. 03
    Elli EF3 papers · 2026

    Department of Surgery, Mayo Clinic, Jacksonville, FL, USA.

    Papers in Europe PMC
  4. 04
    Endo S3 papers · 2026

    Department of Digestive Surgery, Kawasaki Medical School, 577, Matsushima, Kurashiki, Okayama, 701-0192, Japan. endo-s@med.kawasaki-m.ac.jp.

    Papers in Europe PMC
  5. 05
    Erben Y3 papers · 2026

    Division of Vascular and Endovascular Surgery, Mayo Clinic, Jacksonville, FL.

    Papers in Europe PMC
  6. 06
    Farres H3 papers · 2026

    Division of Vascular and Endovascular Surgery, Mayo Clinic, Jacksonville, FL. Electronic address: Farres.Houssam@mayo.edu.

    Papers in Europe PMC
  7. 07
    Higashida M3 papers · 2026

    Department of Digestive Surgery, Kawasaki Medical School, 577, Matsushima, Kurashiki, Okayama, 701-0192, Japan.

    Papers in Europe PMC
  8. 08
    Kiudelis M3 papers · 2026

    Department of Surgery, Medical Academy, Lithuanian University of Health Science, 44307 Kaunas, Lithuania; (M.P.); (I.R.); (M.K.)

    Papers in Europe PMC
  9. 09
    Nagarsheth K3 papers · 2025

    Department of Vascular Surgery, University of Maryland Medical System, Baltimore, Maryland, USA.

    Papers in Europe PMC
  10. 10
    Nakamura M3 papers · 2026

    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

1

interventional trials for this specific condition

1 interventional trial matched this specific condition name; 1 currently recruiting in our sample.

Data as of 11 September 2026

1 interventional trial — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 80.1th percentile).

low confidence · 80.1th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

1 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 0 · after dedupe 0 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 0 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Celiac artery compression syndrome — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Celiac artery compression syndrome" OR "Dunbar syndrome" OR "Median arcuate ligament syndrome" OR "celiac artery stenosis from compression by median arcuate ligament of diaphragm" OR "celiac artery stenosis from compression by median arcuate ligament of the diaphragm" OR "coeliac artery compression syndrome" OR "median arcuate ligament syndromic disease" OR "syndromic disease of median arcuate ligament" OR "syndromic disease of the median arcuate ligament"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: [OBSOLETE] Celiac Artery Stenosis from Compression by Median Arcuate Ligament of Diaphragm

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Celiac artery compression syndrome" OR "Dunbar syndrome" OR "Median arcuate ligament syndrome" OR "celiac artery stenosis from compression by median arcuate ligament of diaphragm" OR "celiac artery stenosis from compression by median arcuate ligament of the diaphragm" OR "coeliac artery compression syndrome" OR "median arcuate ligament syndromic disease" OR "syndromic disease of median arcuate ligament" OR "syndromic disease of the median arcuate ligament" OR "[OBSOLETE] Celiac Artery Stenosis from Compression by Median Arcuate Ligament of Diaphragm"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 1 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: suspect — strategies attempted: phrase, mesh; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: MALS

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (1101) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T12:20:37.268Z