ORPHA:292
Congenital enterovirus infection
Also known as: Antenatal enterovirus infection · Mother-to-child transmission of enterovirus infection
Publications
11
18.9th percentile
Trials
0
Interventional, condition-specific
Researchers
45
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
An infectious embryofetopathy including coxsackie viruses and ECHO viruses that have been reported to cause spontaneous abortion, stillbirth, acute systemic illness in the newborn, and possibly fetal malformations.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0017375
- UMLS:C4274223
Additional Mondo synonyms (5)
antenatal enterovirus infection · congenital enterovirus infection · congenital enterovirus infectious disease · congenital infection caused by enterovirus · mother-to-child transmission of enterovirus infection
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
11 matched papers (4 in last 10 years) Source
- Phenotype characterisedPresent
39 HPO annotations (e.g. Thrombocytopenia; Abnormality of the digestive system; Decreased fetal movement) Source
- Animal modelNot found
No Alliance genotype “model of” associations via Monarch for these Mondo IDs
- Orphan designationNot found
No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
39
Associated phenotypes · MONDO:0017375
- Thrombocytopenia
- Abnormality of the digestive system
- Decreased fetal movement
- Polyhydramnios
- Premature birth
Showing 5 of 39 — open Monarch for the full list.
Animal models (Monarch / Alliance)
None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.
Monarch fetch 2026-07-29
Therapies
Designations, candidates, and chemicals
FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.
Orphan designation (FDA · EMA)
No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.
Open Targets candidates
No drugs or clinical candidates returned for this Mondo ID on Open Targets.
CTD chemicals (MyDisease.info)
No CTD chemical associations returned for this Mondo ID.
Literature
Is anyone studying this?
11
11 papers have ever been indexed under this name. For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.
11 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).
4 in the last 10 years · high confidence · 18.9th percentile (publications denominator)
Phrase hits: 11 · MeSH hits: 0
Who's working on it?
45
Distinct author names in 11 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Lozovskaia LS3 papers · 1991Papers in Europe PMC
- 02Abzug MJ1 paper · 1997Papers in Europe PMC
- 03Bamford A1 paper · 2024
Department of Paediatric Infectious Diseases Great Ormond Street Hospital London UK.
Papers in Europe PMC - 04Breuer J1 paper · 2024
Department of Paediatric Infectious Diseases Great Ormond Street Hospital London UK.
Papers in Europe PMC - 05Bruck G1 paper · 2020
Service de Gynécologie-Obstétrique, CHR Citadelle, Liège, Belgique.
Papers in Europe PMC - 06Burns JE1 paper · 2024
UCL Centre for Clinical Research in Infection and Sexual Health Institute for Global Health London UK.
Papers in Europe PMC - 07Chantraine F1 paper · 2020
Service de Gynécologie-Obstétrique, CHR Citadelle, Liège, Belgique.
Papers in Europe PMC - 08Chen DE1 paper · 2014
Department of Epidemiology and Biostatistics, Wuhan University School of Public Health Wuhan 430071, China.
Papers in Europe PMC - 09Cortisse N1 paper · 2020
Service de Pédiatrie, Hôpital St. Nikolas, Eupen, Belgique.
Papers in Europe PMC - 10Ding YQ1 paper · 2021
LongHua Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 11 September 2026 · last trial check 11 September 2026
No matched interventional trials. This is true for 77.2% of diseases in the trials denominator (5501 of 7126). Here are the researchers publishing on it.
high confidence · 38.6th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Other registries (secondary)
Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.
raw 2 · after dedupe 2 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 2 · dropped 0 · fetched 2026-07-29
Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri
No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).
Uncertain / not reviewed (2)
- isrctn·ISRCTN66872125·No longer recruiting·Community-acquired sepsis-like syndrome and paediatric acute respiratory tract infection in childhood study
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN76926623·No longer recruiting·Milrinone treatment versus conventional standard management for children with enterovirus 71-induced pulmonary oedema and/or neurogenic shock
skipped — LLM skipped (--skip-llm)
Where to find support
Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.
Orphanet entry for Congenital enterovirus infection — check Associations / patient organisations on that page.
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Congenital enterovirus infection" OR "Antenatal enterovirus infection" OR "Mother-to-child transmission of enterovirus infection" OR "Mother-to-child transmission of the enterovirus infection" OR "congenital enterovirus infectious disease" OR "congenital infection caused by enterovirus"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Congenital enterovirus infection" OR "Antenatal enterovirus infection" OR "Mother-to-child transmission of enterovirus infection" OR "Mother-to-child transmission of the enterovirus infection" OR "congenital enterovirus infectious disease" OR "congenital infection caused by enterovirus"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-26T13:17:40.704Z